Smo

Smo

A class F G protein-coupled receptor named Smoothened (Smo) transmits the Hedgehog (Hh) signal across the cell membrane. Both canonical and noncanonical pathways make up the Hh signaling pathway. Major Hh molecules like Hh ligands, PTCH, Smo, and GLI are involved in the canonical Hh pathway's operation, whereas Smo or GLI are activated through other pathways in the noncanonical Hh pathway.

The Hh protein ligand binds to its cellular membrane receptor, Patched (PTCH), relieving PTCH-mediated repression of the seven-transmembrane (7TM) protein Smo to start the Hh signaling cascade. The GLI family of transcription factors receive the signal from activated Smo and transmit it to the nucleus, where they translocate to control numerous genes involved in cell differentiation and tissue patterning.

Smo related products

Structure Cat No. Product Name CAS No. Product Description
V69128 (Rac)-SAG 364590-63-6
V22173 HhAntag 496794-70-8 HhAntag is a novel and potent GLI1-mediated transcription inhibitor and SMOantagonistwith anticancer activity.
V80355 IHR-Cy3
V50986 KAAD-Cyclopamine 306387-90-6 smoothened antagonist, hedgehog signaling inhibitor
V69130 LEQ506 (NVP-LEQ506) 1204975-42-7
V2018 MK-4101 HCI 935273-79-3 MK-4101 HCl (MK 4101; MK4101)is a novel, potent and selective SMO inhibitor/antagonist of the Hedgehog (Hh) signaling pathway.
V2914 MK-4101 935273-79-3 MK-4101 is a novel, potent and selective SMO inhibitor/antagonist of the Hedgehog (Hh) signaling pathway.
V69133 MRT-10 330829-30-6
V69132 MRT-81 1263132-08-6
V69134 PF-5274857 hydrochloride 1613439-62-5
V69129 SAG dihydrochloride 2702366-44-5
V7879 SAG hydrochloride 2095432-58-7 Smoothened Agonist (SAG) HCl is a potent and cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.
V76538 SAG-d3
V69131 SMANT hydrochloride 1177600-74-6
V0099 Sonidegib phosphate (NVP-LDE-225, Erismodegib, Odomzo) 1218778-77-8 Sonidegib phosphate orSonidegib diphosphate, the diphosphate salt of sonidegib (also known as NVP-LDE225, Erismodegib, Sonidegib; trade name ofOdomzo) is a potent and orally bioavailable small-molecule antagonist of the Smoothened (Smo) with potential anticancer activity.
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