Acetyl-CoA Carboxylase

Acetyl-CoA Carboxylase

The ATP-dependent carboxylation of acetyl-CoA, a rate-limiting step in the synthesis of fatty acids, is catalyzed by acetyl-CoA carboxylase. Acetyl-CoA carboxylase is a desirable target for the development of drugs to treat diabetes, cancer, and other diseases because of its critical roles in fatty acid metabolism.

Animals have two main ACC isoforms, ACC1 and ACC2, which are each encoded by a different gene and have different distributions in different tissues and cells. ACC, which is mediated by the related enzymes ACC1 and ACC2, catalyzes the ATP-dependent carboxylation of acetyl-CoA to form malonyl-CoA as the first committed step of fatty acid synthesis (FASyn). While ACC2 is attached to the mitochondrial outer membrane, where localized malonyl-CoA production inhibits carnitine palmitoyltransferase-1 (CPT-1) function to stop fatty acids from entering the mitochondria to undergo fatty acid oxidation (FAOxn), ACC1 encodes a cytoplasmic isoform that is thought to be the predominant isoform controlling FASyn.

Acetyl-CoA Carboxylase related products

Structure Cat No. Product Name CAS No. Product Description
V4530 CMS121 1353224-53-9 CMS-121 (CMS121) is a novel and potent fisetin-basedquinolonederivative acting as anorally active acetyl-CoA carboxylase 1 (ACC1) inhibitorwith anti-aging, neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities.
V73884 CP-610431 591778-83-5
V2852 CP640186 HCl 591778-70-0 CP-640186 HCl is a novel and potent inhibitor of mammalian ACCs (isozyme-nonselective acetyl-CoA carboxylase) with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; It hash improved metabolic stability in comparison to CP-610431, an analog of CP-640186.
V73881 Firsocostat (S enantiomer) (ND-630 (S enantiomer); GS-0976 (S enantiomer); NDI-010976 (S enantiomer)) 2128714-16-7
V73880 Fluazifop-P-butyl 79241-46-6
V73882 Haloxyfop 69806-34-4
V4302 MK-4074 1039758-22-9 MK-4074 is a novel, potent and liver-specific inhibitor ofacetyl-CoA carboxylaseACC1 and ACC2 which are enzymes that produce malonyl-CoA for fatty acid synthesis, withIC50values of 3 nM.
V3778 ND-630 S enantiomer ND-630 S enantiomer, the S enantiomer of ND-630 (also known as GS-0976; NDI-010976; firsocostat), is a potent inhibitor of ACC (acetyl-CoA carboxylase).
V73879 Quizalofop-P 94051-08-8
V73883 Sethoxydim (BAS 9052) 74051-80-2
V3018 TOFA 54857-86-2 TOFA (5‑tetradecyloxy‑2‑furoic acid), also known as RMI14514 and MDL14514, is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA).
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