The ATP-dependent carboxylation of acetyl-CoA, a rate-limiting step in the synthesis of fatty acids, is catalyzed by acetyl-CoA carboxylase. Acetyl-CoA carboxylase is a desirable target for the development of drugs to treat diabetes, cancer, and other diseases because of its critical roles in fatty acid metabolism.
Animals have two main ACC isoforms, ACC1 and ACC2, which are each encoded by a different gene and have different distributions in different tissues and cells. ACC, which is mediated by the related enzymes ACC1 and ACC2, catalyzes the ATP-dependent carboxylation of acetyl-CoA to form malonyl-CoA as the first committed step of fatty acid synthesis (FASyn). While ACC2 is attached to the mitochondrial outer membrane, where localized malonyl-CoA production inhibits carnitine palmitoyltransferase-1 (CPT-1) function to stop fatty acids from entering the mitochondria to undergo fatty acid oxidation (FAOxn), ACC1 encodes a cytoplasmic isoform that is thought to be the predominant isoform controlling FASyn.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V97305 | (Rac)-Spirotetramat-enol | 382608-09-5 | (Rac)-Spirotetramat-enol (Compound 8) is a ligand for acetyl-CoA carboxylase and can be used to synthesize PROTAC ADC degraders. |
|
V3018 | TOFA (Olumacostat) | 54857-86-2 | TOFA (5‑tetradecyloxy‑2‑furoic acid), also known as RMI14514 and MDL14514, is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA). |
|
V99615 | ACC1-IN-2 | 3027705-67-2 | ACC1-IN-2 (Compound 16) is an inhibitor of ACC1 with IC50 of 7.3 nM. |
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V4530 | CMS121 | 1353224-53-9 | CMS-121 (CMS121) is a novel and potent fisetin-basedquinolonederivative acting as anorally active acetyl-CoA carboxylase 1 (ACC1) inhibitorwith anti-aging, neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities. |
|
V73884 | CP-610431 | 591778-83-5 | CP-610431 is a reversible, ATP-noncompetitive, isoenzyme-nonselective inhibitor of acetyl-CoA carboxylase (ACC). |
|
V2852 | CP640186 HCl | 591778-70-0 | CP-640186 HCl is a novel and potent inhibitor of mammalian ACCs (isozyme-nonselective acetyl-CoA carboxylase) with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; It hash improved metabolic stability in comparison to CP-610431, an analog of CP-640186. |
|
V73881 | Firsocostat (racemate) | 2128714-16-7 | Firsocostat (racemate) (ND-630 racemate) is the racemate (R/S-isomer) of Firsocostat. |
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V3778 | Firsocostat (S enantiomer) | 2128714-16-7 | ND-630 S enantiomer, the S enantiomer of ND-630 (also known as GS-0976; NDI-010976; firsocostat), is a potent inhibitor of ACC (acetyl-CoA carboxylase). |
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V93087 | Fluazifop | 69335-91-7 | Fluazifop is a selective herbicide that acts by inhibiting acetyl-CoA carboxylase. |
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V73880 | Fluazifop-P-butyl | 79241-46-6 | Fluazifop-P-butyl is an herbicide developed from arylphenoxypropionate and an acetyl-CoA carboxylase (ACCase) inhibitor. |
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V104777 | Gigantetrocin | 134955-48-9 | Gigantetrocin is a biologically active annona acetyl-CoA from goniothalamus giganteus. |
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V73882 | Haloxyfop | 69806-34-4 | Haloxyfop is an arylchlorooxyphenoxypropionic acid herbicide that is extensively used on weeds in broadleaf crops. |
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V4302 | MK-4074 | 1039758-22-9 | MK-4074 is a novel, potent and liver-specific inhibitor ofacetyl-CoA carboxylaseACC1 and ACC2 which are enzymes that produce malonyl-CoA for fatty acid synthesis, withIC50values of 3 nM. |
|
V87265 | QPP-I-6 | 2864442-05-5 | QPP-I-6 is an inhibitor of acetyl-CoA carboxylase (ACCase). |
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V73879 | Quizalofop-P | 94051-08-8 | Quizalofop-P is absorbed through the stems and leaves of weeds, conducts upward and downward bidirectionally in the plant body, accumulates at the top and middle meristes, inhibits cell fatty acid synthesis, and causes weed necrosis. |
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V73883 | Sethoxydim (BAS 9052) | 74051-80-2 | Sethoxydim is a post-emergent herbicide. |
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