EAAT

EAAT

EAATs, or excitatory amino acid transporters, are the main extracellular glutamate transporters in the nervous system. In addition to demonstrating an impressive capacity to control extracellular glu concentrations in the environment, this family of five carriers (EAAT1-5) also exhibits the capacity to control the temporal and spatial profile of glu after vesicular release. Ionotropic and metabotropic receptor activation at the synaptic, perisynaptic, and spillover levels is mediated by this dynamic form of regulation. EAATs possess a thermodynamically uncoupled ligand gated anion channel activity in addition to a secondary active, electrogenic process, both of which have been shown to be important for controlling cellular activity.

In the removal of glutamate, the glial glutamate transporter EAAT2 is crucial. Transcriptional or translational activation can cause an upregulation of EAAT2. Potential targets for the treatment of excitotoxicity include EAAT2.

EAAT related products

Structure Cat No. Product Name CAS No. Product Description
V74182 (±)-HIP-A 227619-64-9 (±)-HIP-A is a potent, noncompetitive excitatory amino acid (AA) transporter (EAAT) blocker that effectively blocks Glu uptake (IC50=17-18 μM).
V74186 (±)-HIP-B 227619-65-0 (±)-HIP-B is a potent, noncompetitive excitatory amino acid (AA) transporter (EAAT) blocker that can effectively block Glu uptake (IC50=17-18 μM).
V74191 (±)-threo-3-Methylglutamic acid ((+/-)-3--Methylglutamic acid) 63088-04-0 (±)-threo-3-Methylglutamic acid is a potent EAAT2/4 inhibitor.
V74184 DL-TBOA 205309-81-5 DL-TBOA is a potent, non-transportable inhibitor of excitatory amino acid (AA) transporters, with IC50s of 70 μM, 6 μM and 6 μM for excitatory amino acid (AA) transporter 1 (EAAT1), EAAT2 and EAAT3, respectively.
V74188 DL-TBOA ammonium 2093503-71-8 DL-TBOA ammonium is a potent non-transportable excitatory amino acid (AA) transporter inhibitor (antagonist) with IC50s of 70 μM, 6 μM and 6 μM for excitatory amino acid (AA) transporter 1 (EAAT1), EAAT2 and EAAT3 respectively.
V74190 EAAT2 activator 1 892415-28-0 EAAT2 activator 1 is a potent activator of excitatory amino acid (AA) transporter 2 (EAAT2).
V4751 Kainic acid 487-79-6 Kainic acid is a novel and potentexcitatory amino acid and an agonist at excitatory amino acid receptorsubtypes in the CNS.
V74185 L-threo-3-Hydroxyaspartic acid (L(-)-THREO-3-Hydroxyaspartic acid) 7298-99-9 L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor (antagonist) with Ki of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3 respectively in HEK293 cells.
V84452 TAOA AM Ester trimethyl lock
V74187 TFB-TBOA (CF3-Bza-TBOA) 480439-73-4 TFB-TBOA (CF3-Bza-TBOA) is a potent glutamate transporter blocker that can effectively inhibit the activity of glial transporters.
V27803 UCPH-101 1118460-77-7 UCPH-101 is an inhibitor (blocker/antagonist) of excitatory amino acid (AA) transporter subtype 1 (EAAT1) with IC50 of 0.66 μM.
V74189 WAY-213613 hydrochloride 2450268-84-3 WAY-213613 ( HCl) is a potent and specific inhibitor of human EAAT2.
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