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Ceramidase

Ceramidase

Ceramidases are a group of enzymes that catalyze the hydrolysis of ceramide, dihydroceramide, and phytoceramide into sphingosine (SPH), dihydrosphingosine (DHS), and phytosphingosine (PHS), respectively, along with a free fatty acid.Ceramidases, which play a crucial role in the pathophysiology of diseases with altered lipid homeostasis like Alzheimer's disease, type 2 diabetes-induced insulin resistance, cancer, and cardiovascular conditions, regulate the breakdown of ceramides. According to the pH ideal for their catalytic activity, ceramidases are divided into the acid, neutral, and alkaline ceramidase subtypes.

Ceramidase related products

Structure Cat No. Product Name CAS No. Product Description
(S,S)-Z-FA-FMK V73028 (S,S)-Z-FA-FMK 105637-38-5 (S,S)-Z-FA-FMK is a cell-permeable (penetrable), irreversible inhibitor of cathepsin B.
6,6′-Dihydroxythiobinupharidine V73063 6,6′-Dihydroxythiobinupharidine 30343-70-5 6,6′-Dihydroxythiobinupharidine is a cysteine proteases inhibitor.
ABP 25 V73051 ABP 25 2965359-45-7 ABP 25 is an activity-based probe for imaging cathepsin K with good potency and selectivity.
Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 V73052 Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 400716-78-1 Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 is a cathepsin D substrate for cathepsin D FRET Determination.
Ac-Leu-Val-Lys-Aldehyde V73062 Ac-Leu-Val-Lys-Aldehyde 147600-40-6 Ac-Leu-Val-Lys-Aldehyde is a potent inhibitor of cathepsin B with IC50 of 4 nM.
Ac-VLPE-FMK (Ac-Val-Leu-Pro-Glu(OMe)-CH2F) V73060 Ac-VLPE-FMK (Ac-Val-Leu-Pro-Glu(OMe)-CH2F) 2679825-27-3 Ac-VLPE-FMK is a tetrapeptide monofluoromethyl ketone (m-FMK), a Cat-B and Cat-L inhibitor.
Acid Ceramidase-IN-1 V73923 Acid Ceramidase-IN-1 2415225-30-6 Acid Ceramidase-IN-1 is a potent orally bioavailable acid ceramidase (AC, ASAH-1) inhibitor (hAC IC50=0.166 μM).
Acid Ceramidase-IN-2 V73924 Acid Ceramidase-IN-2 1005497-03-9 Acid Ceramidase-IN-2 (compound 1) is an acid ceramidase (ceramidase) inhibitor (antagonist) with potential antiproliferation and cytostatic activity.
Arg-Arg-AMC V73064 Arg-Arg-AMC 263843-55-6 Arg-Arg-AMC is a selective substrate for Cathepsin B.
ARN14974 V3381 ARN14974 1644158-57-5 ARN14974 (ARN-14974), a benzoxazolone carboxamide analog, is a novel and potent inhibitor of acid ceramidase with IC50of 79 nM.
ASPER-29 V73047 ASPER-29 2630388-03-1 ASPER-29 is an analog of Asperphenamate.
Aurantiamide acetate (Asperglaucide) V73032 Aurantiamide acetate (Asperglaucide) 56121-42-7 Aurantiamide acetate is a selective and orally bioactive cathepsin inhibitor extracted from Portulaca oleracea L.
Calpain-1 (pig) (μ-Calpain) V73058 Calpain-1 (pig) (μ-Calpain) 689772-75-6 Calpain-1 (pig) (μ-Calpain) is an intracellular Ca2+-regulated cysteine protease.
Cathepsin C-IN-3 V73055 Cathepsin C-IN-3 2825567-71-1 Cathepsin C-IN-3 (compound SF11) is a potent inhibitor of cathepsin C (Cat C) with IC50 of 61.79 nM.
Cathepsin C-IN-4 V73056 Cathepsin C-IN-4 2825567-86-8 Cathepsin C-IN-4 (compound SF27) is a potent inhibitor of cathepsin C (Cat C) with IC50 of 65.6 nM.
Cathepsin C-IN-5 V73033 Cathepsin C-IN-5 2825567-97-1 Cathepsin C-IN-5 (compound SF38) is a specific and orally bioactive cathepsin C inhibitor (antagonist) with IC50s of 59.9 nM for Cat C, Cat L, Cat S, Cat B and Cat K respectively.
Cathepsin D and E FRET Substrate V73049 Cathepsin D and E FRET Substrate 839730-93-7 Cathepsin D and E FRET Substrate is a fluorogenic substrate for cathepsin D and E, not for B, H or I, and its cleavage occurs at the Phe-Phe amide bond.
Cathepsin G Inhibitor I V73034 Cathepsin G Inhibitor I 429676-93-7 Cathepsin G Inhibitor I is a potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G.
Cathepsin K inhibitor 3 V73037 Cathepsin K inhibitor 3 1694638-70-4 Cathepsin K inhibitor 3 (compound 23) is a selective cathepsin K inhibitor (antagonist) with IC50 of 0.5 nM.
Cathepsin K inhibitor 5 V73044 Cathepsin K inhibitor 5 448945-62-8 Cathepsin K inhibitor 5 is a potent cathepsin K inhibitor.
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