The rhodopsin-like G protein-coupled receptor (GPCR) family includes the gonadotropin-releasing hormone receptor (GNRHR), which is made up of seven transmembrane helical domains connected by extracellular and intracellular segments. Gonadotrophs, pituitary cells that produce the gonadotrophins LH and FSH, have a GnRH receptor on their plasma membrane.
Different ligand preferences for GnRH-I and GnRH-II are shown by mammalian type I and type II GnRH receptors, respectively. All GnRH receptors activate the Gq/11 family of G proteins, which in turn activates the production of second messengers that in turn activates protein kinase C (PKC) through the phospholipase C pathway. LH and FSH are produced and released more quickly when the GnRH receptor is activated by GnRH analogues. GnRH receptors have a variety of medical and veterinary applications, including the study of breast and prostate cancer, the control of fertility, endometriosis, and other conditions.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V75391 | (D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH | 1926163-38-3 | (D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH is an analog of luteinizing hormone-releasing hormone (LHRH). |
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V75392 | (D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH | 1926163-39-4 | (D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH is an analog of luteinizing hormone-releasing hormone (LHRH). |
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V75393 | (D-Trp6)-LHRH free acid | 129418-54-8 | (D-Trp6)-LHRH free acid is a luteinizing hormone-releasing hormone (LHRH) agonist. |
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V75390 | (D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH | 1426173-74-1 | (D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH is an analog of luteinizing hormone-releasing hormone (LHRH). |
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V60341 | (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon) | 88848-87-7 | (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon) is a GnRH analog that induces ovulation and/or spawning in farmed fish. |
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V77381 | (R)-BAY-899 | (R)-BAY-899 is the R-isomer of BAY-899. | |
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V75389 | [D-Ala6]-LH-RH | 51230-19-4 | [D-Ala6]-LH-RH is a luteinizing hormone-releasing hormone (LHRH) analog that works as a GnRH receptor agonist (activator). |
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V40902 | [D-Arg6,Pro9-NEt]Salmon gonadotropin-releasing hormone | 96497-82-4 | sGnRH-A is a salmon gonadotropin-releasing hormone (GnRH) analog. |
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V75397 | [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH | 68059-94-9 | [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH is a luteinizing hormone-releasing hormone (LHRH) analog that works as a GnRH receptor blocker (antagonist). |
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V77475 | [D-Leu6, Val7]-LH-RH (1-9) Ethyl Amide | [D-Leu6, Val7]-LH-RH (1-9) Ethyl Amide is a bioactive peptide analog of LHRH. | |
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V75402 | [D-Lys6]-LH-RH | 52671-12-2 | [D-Lys6]-LH-RH is a luteinizing hormone-releasing hormone (LHRH) analog that works as a GnRH receptor agonist (activator). |
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V9909 | Abarelix | 183552-38-7 | Abarelix (R3827) is a potent gonadotropin-releasing hormone (GnRH) antagonist utilized in study/research of prostate cancer. |
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V75385 | Abarelix Acetate (Abarelix Acetate; PPI 149 Acetate; R 3827 Acetate) | 547741-72-0 | Abarelix (R3827) Acetate is a potent gonadotropin-releasing hormone (GnRH) antagonist utilized in study/research of prostate cancer. |
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V77290 | Acyline TFA | Acyline TFA, a GnRH peptide analog, is a GnRH antagonist that suppresses gonadotropin and testosterone (T) levels. | |
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V10669 | Alarelin Acetate | 79561-22-1 | Alarelin acetate is a synthetic GnRH agonist. |
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V50930 | Antide acetate | 625092-10-6 | gonadotropin-releasing hormone receptor antagonist |
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V75386 | BAY-298 | 2471978-97-7 | BAY-298 is an orally bioactive and selective luteinizing hormone receptor (LH-R) antagonist (inhibitor) with IC50 for hLH (human LH), rLH (rat LH) and cLH (cynomolgus monkey LH), respectively. |
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V75384 | BAY-899 | 2471967-92-5 | BAY-899 is an orally potent and specific luteinizing hormone receptor (LH-R) antagonist (inhibitor) with IC50s of 185 nM and 46 nM for hLH (human LH) and rLH (rat LH), respectively. |
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V4630 | Cetrorelix acetate (SB-75) | 145672-81-7 | Cetrorelix mono-acetate (SB-75) is a novel, potent and synthetic gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM. |
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V4133 | Degarelix | 214766-78-6 | Degarelix is a competitive, reversible gonadotropin-releasing hormone receptor (GnRHR/LHRHR) antagonist. |
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