Sigma Receptor

Sigma Receptor

The entire mammalian body expresses a special class of binding sites known as sigma receptors (subtypes sigma-1 and sigma-2). Although the endogenous ligand for these sites has not been discovered, N,N-dimethyltryptamine, sphingolipid-derived amines, and steroid hormones—especially progesterone—can bind with a fair amount of affinity.

The sigma-1 receptor (1R) is a chaperone protein that resides in the endoplasmic reticulum (ER) and functions as a modulator of inter-organelle signaling. Numerous biological processes, such as nociception, cancer, stroke, memory, drug addiction, cardiac activity, and Alzheimer's disease, are affected by it. Numerous human tumors have an overexpression of the sigma-2 (2R) receptor. It has been proven to be a reliable biomarker for spreading tumors.

Sigma Receptor related products

Structure Cat No. Product Name CAS No. Product Description
V3950 4-IBP 155798-08-6 4-IBP is a novel and selective σ1 (sigma1) agonist with high affinity for the σ1 receptor with Ki of 1.7 nM and a moderate affinity for the σ2 receptor (Ki = 25.2 nM).
V79226 AB10
V79240 AB21
V78890 AB21oxalate
V79439 AD186
V80042 Antidepressant agent 3
V77994 Antidepressant agent 4
V2985 BD 1047 dihydrobromide 138356-21-5 BD1047 dihydrobromide (BD-1047) is a selective functional antagonist of sigma receptors (σ receptors) with antipsychotic activity and may be used for schizophrenia.
V4741 BD1063 HCl 206996-13-6 BD-1063 HCl (BD1063 hydrochloride) is a novel, potent and selective sigma receptor antagonist with the potential for treatingalcoholism.
V71977 Broussoflavonol F 162558-94-3
V70033 CM398 1121931-70-1
V3312 CT-1812 1802632-22-9 CT1812 (Elayta) is a novel, potent andorally bioavailable allosteric antagonist of the sigma-2 receptor complex (sigma-2/PGRMC1) that prevents and displaces binding of Aβ oligomers to neurons.
V0097 Cutamesine (SA 4503; AGY 94806) 165377-43-5 Cutamesine (SA-4503; AGY-94806) is a selective and potent sigma-1 (σ1) receptor agonist with an IC50of 17.4 nM in guinea pig brain membranes, 100-fold less selective for the sigma 2 receptor.
V30747 Dimemorfan phosphate 36304-84-4 Dimemorfan phosphate (Astomin; AT17; Gentus; AT-17) is a morphinan-based sigma 1 receptor agonistwith potent antitussive activity.
V70037 DuP 734 135135-87-4
V2275 EST64454 HCl 1950569-11-5 EST64454HClis a potent ,selective and orally active sigma-1 receptor antagonist( Ki = 22 nM).
V69891 EST73502 monohydrochloride 2535970-65-9
V71980 Eupatoriochromene 19013-03-7
V71979 Febuxostat-d9 (Febuxostat d9) 1246819-50-0
V71976 Forsythoside F (Forsythoside F; Arenarioside) 94130-58-2
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