Bradykinin Receptor

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

+MORE

Bradykinin Receptor

Bradykinin receptors are G protein-coupled receptors (GPCRs), which are found on the surface of cells. B1 and B2 are the two subtypes of bradykinin receptors. Bradykinin receptor-mediated signal transductions are important for regulating pain and inflammation as well as maintaining cardiovascular homeostasis. Both receptors activate G-proteins to transmit extracellular signals.

Bradykinin B2 receptor is ubiquitous and is expressed constitutively, whereas bradykinin B1 receptor is expressed at a very low level in healthy tissues but is induced under stressful conditions like shock or inflammation. Vasodilation, osmoregulation, smooth muscle contraction, and nociceptor activation are all regulated by the bradykinin B2 receptor. Since the bradykinin B1 receptor and bradykinin B2 receptor are linked to inflammatory disease, vasculopathy, neuropathy, obesity, diabetes, and cancer, they have become potential therapeutic targets. B1R and B2R may play opposing roles in various diseases. Therapeutic evaluations of antagonists and agonists have been conducted.

Bradykinin Receptor related products

Cat No.	Product Name	CAS No.	Product Description
V75325	[Phe8Ψ(CH-NH)Arg9]-Bradykinin	118122-39-7	[Phe8Ψ(CH-NH)Arg9]-Bradykinin is a selective bradykinin B2 receptor agonist (activator) (not cleaved by protein kinase I/II).
V94996	Anatibant hydrochloride	209788-45-4	Anatibant (LF 16-0687; XY-2405) hydrochloride is a selective non-peptide bradykinin B2 receptor antagonist.
V75328	B 9430	180981-09-3	B 9430 is a potent bradykinin B1/B2 receptor blocker (antagonist).
V75318	BA 1	183241-31-8	BA 1 is a bombesin (BB) receptor family agonist.
V75319	BIM-26226	136207-23-3	BIM-26226 is a gastrin-releasing peptide and a potent and specific bombesin receptor antagonist.
V75323	Bombinakinin M	509151-65-9	Bombinakinin M is a bradykinin receptor agonist (activator) with contractile activity in the guinea pig ileum.
V86538	Bradykinin B1 receptor antagonist 1	578727-81-8	Bradykinin B1 receptor antagonist 1 (compound 6B) is a potent bradykinin B1 antagonist that crosses the blood-brain barrier.
V75317	BRS-3 receptor agonist-2	1021937-07-4	BRS-3 receptor agonist-2 (compound 2) is a potent BRS-3 receptor agonist/activator with EC50 of 2.5 nM for mouse BRS-3 receptor.
V75324	Des-Arg9-[Leu8]-Bradykinin acetate	115035-45-5	Des-Arg9-[Leu8]-Bradykinin acetate is a potent bradykinin receptor 1 (B1R) antagonist.
V20458	ELN441958	913064-47-8	ELN441958 (ELN-441958) is a novel, potent, and small molecule antagonist of neutral bradykinin B1 receptor which inhibits the binding of the B1 agonist ligand [3H]DAKD to IMR-90 cells with Ki of 0.26 nM.
V75322	Fasitibant chloride (MEN16132 free base)	1157852-02-2	Fasitibant chloride (MEN16132 free base) is a specific, non-peptide bradykinin B2 receptor (B2R) antagonist.
V75330	Fasitibant free base	869939-83-3	Fasitibant (free base) is a specific, high-affinity, long-acting non-peptide bradykinin B2 receptor (BK2 receptor) antagonist.
V75316	GB-6	2413262-74-3	GB-6 is a short linear peptide that targets the gastrin-releasing peptide receptor (GRPR).
V75331	Icatibant acetate (HOE 140 acetate)	138614-30-9	Icatibant acetate (HOE-140 acetate) is a potent and specific bradykinin B2 receptor antagonist (inhibitor) with IC50 and Kis of 1.07 nM and 0.798 nM respectively.
V75329	Lys-[Des-Arg9]Bradykinin TFA	2763588-90-3	Lys-[Des-Arg9]Bradykinin TFA is a naturally occurring kinin that is a potent and selective bradykinin B1 receptor agonist/activator with Kis for B1 receptors in humans, mice and rabbits.
V75327	Lys-[Hyp3]-Bradykinin	113662-39-8	Lys-[Hyp3]-Bradykinin is an agonist of Bradykinin.
V94955	Lys-Bradykinin tetraacetate	84640-50-6	Lysine bradykinin (kinin (380-389) (human, porcine, bovine)) tetraacetate is a kinin and bradykinin receptor ligand produced by enzymatic cleavage of kininogen protein by the protease kallikrein.
V86536	Lys-Bradykinin TFA		Lys-Bradykinin TFA is the TFA salt form of Lys-Bradykinin.
V75321	MEN 11270	235082-52-7	MEN 11270 is a cyclic decapeptide and a B2 kinin receptor antagonist.
V75326	R715	185052-09-9	R715 is a selective bradykinin B1 receptor blocker (antagonist).