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MIF

MIF

Proinflammatory cytokine Macrophage Migration Inhibitory Factor (MIF) is encoded within a functionally polymorphic genetic locus. MIF, a 12.5 kDa secretory protein with a high degree of conservation, functions in numerous biological processes. MIF appears to be ubiquitously and constitutively expressed in almost all mammalian cells and is essential for a variety of physiological processes, according to the expression and secretion profile. MIF is a pleiotropic inflammatory cytokine that has been linked to the pathogenesis of autoimmune diseases like rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). It is crucial in the upstream regulation of both innate and adaptive immune responses.

MIF related products

Structure Cat No. Product Name CAS No. Product Description
4,5-二氢-3-(4-羟基苯基)-5-异恶唑乙酸甲酯 V9770 ISO-1 478336-92-4 ISO-1, formerly known as MIF Antagonist and ISO-1 and Macrophage Migration Inhibitory Factor, is a MIF inhibitor.
HTS05585 V137624 HTS05585 696643-14-8 HTS05585 is a selective macrophage migration inhibitory factor (MIF) inhibitor with a Kd value of 0.29 μM as measured by microscale thermophoresis (MST) and 0.32 ± 0.01 μM as verified by isothermal titration calorimetry (ITC).
ISO-92 V138105 ISO-92 899433-49-9 ISO-92 is a MIF inhibitor.
MKA031 V80788 MKA031 2951012-00-1 MKA031 (compound 6y) is a noncompetitive MIF inhibitor (antagonist) with IC50 of 1.7 μM.
PAANIB-1 V142102 PAANIB-1 2634726-71-7 PAANIB-1 is an inhibitor of apoptosis-associated inducible factor nuclease (PAAN)/macrophage migration inhibitory factor (MIF).
R110 V75084 R110 1985622-33-0 R110 is a potent, competitive macrophage migration inhibitory factor (MIF2) tautomerase inhibitor (antagonist) with IC50 of 15 μM.
RDR 03785 V75083 RDR 03785 289657-30-3 RDR 03785 is a covalent MIF inhibitor (antagonist) with IC50 of 0.36 μM.
RGB097 V86898 RGB097 RGB097 is a potent D-dopachrome tautomerase (D-DT) inhibitor with IC50 of 0.5 µM.
Spirohexenolide A V100241 Spirohexenolide A 1193347-22-6 Spirohexenolide A is a human macrophage migration inhibitory factor (hMIF) inhibitor with Kd of 35.9 μM.
TE-11 V145704 TE-11 160488-11-9 TE-11 is a MIF tautomerase inhibitor with an IC50 of 5.63 μM.
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