Proinflammatory cytokine Macrophage Migration Inhibitory Factor (MIF) is encoded within a functionally polymorphic genetic locus. MIF, a 12.5 kDa secretory protein with a high degree of conservation, functions in numerous biological processes. MIF appears to be ubiquitously and constitutively expressed in almost all mammalian cells and is essential for a variety of physiological processes, according to the expression and secretion profile. MIF is a pleiotropic inflammatory cytokine that has been linked to the pathogenesis of autoimmune diseases like rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). It is crucial in the upstream regulation of both innate and adaptive immune responses.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V75086 | Imalumab (BAX69; Anti-Human MIF Recombinant Antibody) | 1430205-07-4 | Imalumab (BAX69) is a recombinant, human IgG1 monoclonal antibody (mAb) targeting macrophage inhibitory factor (MIF). |
|
V9770 | ISO-1 | 478336-92-4 | ISO-1, formerly known as MIF Antagonist and ISO-1 and Macrophage Migration Inhibitory Factor, is a MIF inhibitor. |
|
V80788 | MKA031 | MKA031 (compound 6y) is a noncompetitive MIF inhibitor (antagonist) with IC50 of 1.7 μM. | |
|
V75084 | R110 | 1985622-33-0 | R110 is a potent, competitive macrophage migration inhibitory factor (MIF2) tautomerase inhibitor (antagonist) with IC50 of 15 μM. |
|
V75083 | RDR 03785 | 289657-30-3 | RDR 03785 is a covalent MIF inhibitor (antagonist) with IC50 of 0.36 μM. |
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