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Cannabinoid Receptor

Cannabinoid Receptor

The three G-protein-coupled cannabinoid receptor subtypes currently recognized are central (CB1), peripheral (CB2), and GPR55. The majority of CB1 receptors are found at central and peripheral nerve terminals. CB2 receptors are mainly found in immune cells and non-neuronal tissues where they regulate cytokine release and cell migration. According to recent reports, the CNS may also express CB2 receptors. Non-CB1/CB2 receptors known as GPR55 show affinity for endogenous, botanical, and synthetic cannabinoids. Anandamide and 2-arachidonylglycerol are examples of endogenous ligands for cannabinoid receptors.

Cannabinoid Receptor related products

Structure Cat No. Product Name CAS No. Product Description
(R)-(+)-Linoleyl-1'-Hydroxy-2'-Propylamide V71597 (R)-(+)-Linoleyl-1'-Hydroxy-2'-Propylamide 220556-74-1 (R)-(+)-Linoleyl-1'-Hydroxy-2'-Propylamide (Compound 19) is an analog of the endocannabinoid receptor ligand Anandamide.
(R)-Monlunabant ((R)-MRI-1891) V71551 (R)-Monlunabant ((R)-MRI-1891) 2765579-76-6 (R)-Monlunabant ((R)-MRI-1891) is a CB1 receptor modulator utilized in study/research of obesity and metabolic diseases.
15(S)-HETE Ethanolamide V71573 15(S)-HETE Ethanolamide 161744-53-2 15(S)-HETE Ethanolamide is an analog of cannabinoids that works on the CB1 receptor (Ki 600 nM).
2-Arachidonoylglycerol V5397 2-Arachidonoylglycerol 53847-30-6 2-Arachidonoylglycerol, an endocannabinoid compound, is an endogenous agonist for the cannabinoid (CB1) receptor in the central nervous system.
2-Palmitoylglycerol (2-Palm-Gl) V71592 2-Palmitoylglycerol (2-Palm-Gl) 23470-00-0 2-Palmitoylglycerol (2-Palm-Gl) is an analog of 2-arachidonoylglycerol (2-AG) and a moderate cannabinoid receptor CB1 agonist.
AEF0117 V71582 AEF0117 1610878-71-1 AEF0117 is a signaling-specific inhibitor of cannabinoid receptor 1 (CB1-SSi).
AM1241 V1516 AM1241 444912-48-5 AM-1241 (AM1241; AM 1241), anaminoalkylindole analog, is a novel, potent and selective cannabinoid (CB2) receptor agonist with potential analgesic effects (pain-killing).
AM251 V1517 AM251 183232-66-8 AM251 (AM-251; AM 251) is a novel, potent and selective cannabinoid (CB) receptor antagonist with potential anti-obesity effect.
AM841 V71584 AM841 871978-21-1 AM841 is a high-affinity electrophilic ligand.
AM8936 V71568 AM8936 2820337-96-8 AM8936 is a balanced and potent agonist of cannabinoid receptor type 1 (CB1) (EC50 for rCB1 and hCB1 of 8.6 and 1.4 nM, respectively).
Anandamide V11283 Anandamide 94421-68-8 Anandamide is an endocannabinoid.
ANEB-001 V71590 ANEB-001 791848-71-0 ANEB-001 is an orally bioactive CB1 inhibitor used to study acute cannabinoid intoxication.
Arachidonylcyclopropylamide (ACPA) V71557 Arachidonylcyclopropylamide (ACPA) 229021-64-1 Arachidonylcyclopropylamide (ACPA) is a potent and specific CB1 receptor agonist.
AZD-1940 V7326 AZD-1940 881413-29-2 AZD1940 is an orally bioactive, high-affinity cannabinoid CB1/CB2 receptor agonist (activator) with pKis of 7.93 and 9.06 for CB1R and CB2R, respectively, and can be used for pain relief research.
Bay 59-3074 V3360 Bay 59-3074 406205-74-1 Bay 59-3074 is a novel, potent, orally active and selective cannabinoid CB1/CB2 receptor partial agonist with Ki values of 48.3 and 45.5 nM at human CB1 and CB2 receptors respectively.
BAY-38-7271 V3361 BAY-38-7271 212188-60-8 BAY-38-7271 is novel, potent, highly selective cannabinoid receptor agonist with the potential for the treatment of traumatic brain injury.
BML-190 (Indomethacin morpholinylamide; IMMA) V1520 BML-190 (Indomethacin morpholinylamide; IMMA) 2854-32-2 BML-190 (formerly IMMA; LM-4131; BML-190; LM4131; BML190; Indomethacin morpholinylamide), is a potent and selective cannabinoid CB2 receptor inverse agonist with potential anti-inflammatory activity.
Boc-MIF-1-Am V78516 Boc-MIF-1-Am Boc-MIF-1-Am (compound 2) is a human dopamine D2 receptor enhancer (EC50=17.82 nM) and a bioconjugate of melanostatin (MIF-1) and amantadine.
Cannabinodiol V71583 Cannabinodiol 39624-81-2 Cannabinodiol is a cannabinoid analog, a type of phytocannabinoid.
CB-25 V71579 CB-25 869376-63-6 CB-25 is a ligand for the CB1 cannabinoid receptor and is a partial agonist.
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