Keap1-Nrf2 is the major regulator of cytoprotective responses to electrophilic chemicals or reactive oxygen species (ROS).Keap1 is an E3 ligase that triggers the ubiquitin-proteasome system (UPS) to degrade Nrf2. In cancer cells, upregulation of Nrf2 induced by Keap1 inactivation is frequently seen. Cancer cells' metabolism and proliferation are accelerated by aberrant Nrf2 activation. In this instance, Nrf2 is a desirable molecule to target therapeutically for the treatment of cancer, and numerous Nrf2 inhibitors are being developed. What's interesting is that Nrf2 induction is reportedly used as a treatment strategy to quicken the body's carcinogen detoxification process and prevent chemical carcinogenesis.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V82250 | (S,R,S)-AHPC-C8-NH2 (VH032-C8-NH2) | 2341796-79-8 | (S,R,S)-AHPC-C8-NH2 (VH032-C8-NH2) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing VH032-based VHL ligand and 1 linker. |
|
V82232 | 25-Hydroxycholesterol-d6 (25-Hydroxycholesterol-d6) | 88247-69-2 | 25-Hydroxycholesterol-d6 is the deuterated form of 25-Hydroxycholesterol. |
|
V31615 | Methyl 3,4-dihydroxybenzoate | 2150-43-8 | Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester) is the primary metabolite of antioxidant polyphenols found in green tea. |
|
V82248 | 3-Methylhistamine dihydrochloride | 36475-47-5 | 3-Methylhistamine di-HCl is a degradation product of histamine. |
|
V82236 | 9,10-Dimethoxycanthin-6-one | 155861-51-1 | 9,10-Dimethoxycanthin-6-one is an alkaloid compound that can inhibit NF-κB with IC50 of 19.5 μM. |
|
V82237 | 9-Hydroxycanthin-6-one | 138544-91-9 | 9-Hydroxycanthin-6-one is an alkaloid compound that can inhibit NF-κB with IC50 of 3.8 μM. |
|
V82244 | AP-1/NF-κB activation inhibitor 1 | 188936-12-1 | AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB-mediated transcription activation (IC50=1 μM) and does not block basal transcription driven by the β-actin promoter. |
|
V82231 | Coenzyme Q6 (Ubiquinone 30) | 1065-31-2 | Coenzyme Q6 (Ubiquinone 30) is a prenylated benzoquinone lipid. |
|
V89041 | Fraxinellone analog 1 | Fraxinellone analog 1 (compound 2) is an effective and rapid activator of the Nrf2-mediated antioxidant defense system, which has a protective effect on glutamate-mediated excitotoxicity and induces the expression of antioxidant genes Gpx4, Sod1 and Nqo1. | |
|
V82253 | Ginger extract | 84696-15-1 | Ginger extract has anticancer, anti~inflammatory, and chemotherapeutic effects in animal models. |
|
V82238 | Goshonoside F5 | 90851-28-8 | Goshonoside F5 can be extracted from the immature fruits of Rubus chingii. |
|
V82251 | Gossypin | 652-78-8 | Gossypin is a flavonoid extracted from Hibiscus vitifolius and has antioxidant, anti-inflammatory, anti-cancer, anti-aging, anti-diabetic and liver-protective activities. |
|
V82241 | Itaconic acid (Itaconic acid; Methylenesuccinic acid) | 97-65-4 | Itaconic acid is a precursor to synthetic polymers, chemicals and fuels that can be synthesized by fungi. |
|
V87869 | Keap1-Nrf2-IN-18 | Keap1-Nrf2-IN-18 (Compound 22) is an orally active Keap1-Nrf2 protein-protein interaction (PPI) inhibitor with favorable pharmacokinetic (PK) properties and more potent in vivo activity in rats. | |
|
V87872 | Keap1-Nrf2-IN-19 | Keap1-Nrf2-IN-19 (compound 33) is an orally active Keap1-Nrf2 protein–protein interaction (PPI) inhibitor with a Kd of 0.0014 μM. | |
|
V87873 | Keap1-Nrf2-IN-20 | Keap1-Nrf2-IN-20 (Compound ZC9) is an inhibitor of the Keap-Nrf2 pathway with a KD2 of 51 nM. | |
|
V82223 | Leukotriene E4-d5 (LTE4-d5) | 1240398-14-4 | Leukotriene E4-d5 is the deuterated form of Leukotriene E4. |
|
V2828 | ML385 | 846557-71-9 | ML-385 is a novel, potent and selective NRF2 inhibitor (Nrf2: nuclear factor E2 related factor 2) with an IC50 of 1.9 µM. |
|
V82230 | NF-κB-IN-11 | 2768833-35-6 | NF-κB-IN-11 (Compound 3i) is an NF-κB inhibitor. |
|
V82235 | NF-κB-IN-8 | 2924565-59-1 | NF-κB-IN-8 competitively antagonizes the binding of LPS to MD-2. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
