Keap1-Nrf2

Keap1-Nrf2

Keap1-Nrf2 is the major regulator of cytoprotective responses to electrophilic chemicals or reactive oxygen species (ROS).Keap1 is an E3 ligase that triggers the ubiquitin-proteasome system (UPS) to degrade Nrf2. In cancer cells, upregulation of Nrf2 induced by Keap1 inactivation is frequently seen. Cancer cells' metabolism and proliferation are accelerated by aberrant Nrf2 activation. In this instance, Nrf2 is a desirable molecule to target therapeutically for the treatment of cancer, and numerous Nrf2 inhibitors are being developed. What's interesting is that Nrf2 induction is reportedly used as a treatment strategy to quicken the body's carcinogen detoxification process and prevent chemical carcinogenesis.

Keap1-Nrf2 related products

Structure Cat No. Product Name CAS No. Product Description
V82250 (S,R,S)-AHPC-C8-NH2 (VH032-C8-NH2) 2341796-79-8
V82232 25-Hydroxycholesterol-d6 (25-Hydroxycholesterol-d6) 88247-69-2
V82248 3-Methylhistamine dihydrochloride 36475-47-5
V82236 9,10-Dimethoxycanthin-6-one 155861-51-1
V82237 9-Hydroxycanthin-6-one 138544-91-9
V82244 AP-1/NF-κB activation inhibitor 1 188936-12-1
V82231 Coenzyme Q6 (Ubiquinone 30) 1065-31-2
V2624 Danshensu 76822-21-4 Danshensu is a naturally occuring phenolic acid of caffeic acid derivatives isolated from Salvia miltiorrhiza, with wide cardiovascular benefit by activating Nrf2 signaling pathway.
V39578 Desfluoro-ezetimibe 302781-98-2 Desfluoro-ezetimibe is the defluorinated impurity of ezetimibe(SCH-58235; SCH 58235;Zetia, Ezetrol),which is a Niemann-Pick C1-like1 (NPC1L1) inhibitor and an effective Nrf2 activator, and has beenused to lower cholesterol levels.
V1878 Ezetimibe (SCH 58235) 163222-33-1 Ezetimibe (also known as SCH-58235)is a potent and selective inhibitor of cholesterol absorption in the gut used to lower cholesterol levels.
V40227 Ezetimibe ketone 191330-56-0 Ezetimibe ketone is a phase-I metabolite of Ezetimibe (SCH58235; SCH-58235;Zetia, Ezetrol),which is a selective inhibitor of cholesterol absorption in the gut used to lower cholesterol levels.
V82253 Ginger extract 84696-15-1
V82238 Goshonoside F5 90851-28-8
V82251 Gossypin 652-78-8
V82241 Itaconic acid (Itaconic acid; Methylenesuccinic acid) 97-65-4
V82223 Leukotriene E4-d5 (LTE4-d5) 1240398-14-4
V31615 Methyl 3,4-dihydroxybenzoate 2150-43-8 Methyl 3,4-dihydroxybenzoate is a novel and potent metabolite of antioxidant polyphenol.
V2828 ML385 846557-71-9 ML-385 is a novel, potent and selective NRF2 inhibitor (Nrf2: nuclear factor E2 related factor 2) with an IC50 of 1.9 µM.
V82230 NF-κB-IN-11 2768833-35-6
V82235 NF-κB-IN-8 2924565-59-1
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