Histamine Receptor

Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
GPCR & G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

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Histamine Receptor

Histamine serves as the endogenous ligand for the class of G protein-coupled receptors known as histamine receptors. The H1 receptor, H2 receptor, H3 receptor, and H4 receptor are the four recognized histamine receptors. A member of the family of G-protein-coupled receptors that resemble Rhodopsin is the histamine receptor H1. This receptor, specifically expressed in smooth muscles, vascular endothelial cells, the heart, and the central nervous system, is triggered by the biogenic amine histamine and is found throughout the body. Gs mediates the positive coupling of H2 receptors to adenylate cyclase. It is a strong inducer of cAMP synthesis, which activates Protein Kinase A. Histamine H3 receptors act as autoreceptors in presynaptic histaminergic neurons and regulate histamine turnover by feedback inhibition of histamine synthesis and release. They are expressed in the central nervous system and to a lesser extent the peripheral nervous system. It has been demonstrated that the mast cell chemotaxis and eosinophil shape change are both mediated by the histamine H4 receptor.

Histamine Receptor related products

Cat No.	Product Name	CAS No.	Product Description
V4406	ABT-239	460746-46-7	ABT-239 is a novel, highly efficacious, non-imidazole class of H3R antagonist and a transient receptor potential vanilloid type 1 (TRPV1) antagonist/inverse agonist developed by Abbott with stimulant and nootropic effects, and has been investigated as a treatment for ADHD, Alzheimer's disease, and schizophrenia.
V4935	Astemizole	68844-77-9	Astemizole (formerly R-43512; Hismanal) is a novel, potent and second-generation antihistamine drug with a long duration of action and is used to diminish allergic symptomsby acting as ahistamine H1-receptor antagonist (IC50= 4 nM).
V1238	Azatadine dimaleate	3978-86-7	Azatadine dimaleate (SCH10649; SCH-10649; Idulamine; Idulian; Lergocil; Optimine; Zadine), the dimaleate salt of azatadine,is a potent histamine and cholinergic inhibitor that has beenapproved for treating allergic rhinitis and chronic urticaria.
V1209	Azelastine HCl (Allergodil)	79307-93-0	Azelastine HCl(Allergodil; Astelin; Optivar; Rhinolast; Azeptin),the hydrochloride salt of azelastine, is a potent, 2nd-generation, and selective histamine receptor antagonist used for the treatment of rhinitis.
V4516	Bavisant dihydrochloride hydrate	1103522-80-0	Bavisant dihydrochloride hydrate (also known as JNJ-31001074 dihydrochloride hydrate) is a novel, highly selective, orally bioactive antagonist of the human H3 receptor with a novel mechanism of action which involves wakefulness and cognition.
V8638	Bepotastine	125602-71-3	Bepotastine (also known as TAU 284; Bepreve) is a second generation, non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7.
V1212	Bepotastine Besilate (Bepreve)	190786-44-8	Bepotastinebesilate(bepotastine besylate; TAU-284; TAU284;Bepreve; Talion), the besylate salt ofBepotastine, is a 2nd generation, non-sedating, and selective antagonist of histamine 1 (H1) receptor with a pIC50 of 5.7.
V1236	Betahistine 2HCl	5579-84-0	Betahistine dihydrochloride (formerly PT 9; PT9; trade names Veserc, Serc, Hiserk, Betaserc, Vergo), the dihydrochloride salt of Betahistine which was pproved in EU in 1970s for treating Ménière's disease, is a potent antagonist of histamine H3 receptor used as an anti-vertigo drug.
V12560	Betahistine mesylate	54856-23-4	Betahistine mesylate (also known as PT-9), the mono-HCl salt of Betahistine, is a potent histamine H3 receptor inhibitor with IC50 of 1.9 μM.
V4908	Bromodiphenhydramine HCl	1808-12-4	Bromodiphenhydramine (Bromazine; trade names: Ambodryl, Ambrodil and others) hydrochloride is the hydrochloride salt form of bromodiphenhydramine, a synthetic ethanolamine with histamine H1 antagonistic and sedative properties.
V1231	Brompheniramine maleate	980-71-2	Brompheniramine (Bromfed, Dimetapp, Bromfenex, Dimetane, BPN, Lodrane), the maleate salt of Brompheniramine which is an OTC drug for cold and allergic rhinitis, is a first-generation antagonist of the histamine H1 receptors.
V1226	Buclizine HCl (UCB-4445)	129-74-8	Buclizine hydrochloride (AH-2526, UCB 4445; AH2526; UCB-4445, Buclina, Longifene, Posdel, Vibazine), the hydrochloride salt of buclizine which is used for motion sickness, is a piperazine derivative and a sedating antihistamine with antimuscarinic and moderate sedative action.
V1218	Cetirizine DiHCl (P071)	83881-52-1	Cetirizine 2HCl (P-071; UCB P071; Reactine; Zyrtec; Alerlisin; AC-170; P071),the dihydrochloride salt of cetirizine and a major active metabolite of hydroxyzine, isa 2nd-generation antihistamine used in the treatment of allergies, hay fever, angioedema, and urticarial etc.
V6698	Chloropyramine	59-32-5	Chloropyramine hydrochloride (Alergosan, Nilfan, Sinopen, Allergan hydrochloride, Suprastin) is an antihistamine drug acting as a histamine receptor H1 antagonist.
V29900	Chloropyramine hydrochloride	6170-42-9	Chloropyramine hydrochloride (Alergosan, Allergan hydrochloride, Nilfan, Sinopen, Suprastin), the hydrochloride salt of Chloropyramine, is a potentantihistamine drug acting as a histamine receptor H1 antagonist.
V1240	Chlorpheniramine Maleate	113-92-8	Chlorpheniramine Maleate (Piriton; Chlortrimeton; Deconamine; Neorestamin; NCIC-55265; NCIC55265; Chlo-Amine; Chlor-100; Chlor-Trimeton), the Maleate salt of Chlorpheniramine, is a potent and 1st-generation alkylamine-based histamine H1 receptor antagonist with anti-allergic effects.
V1220	Cimetidine	51481-61-9	Cimetidine (Tagamet; Cimetag; SKF-92334; Eureceptor; Ulcedine), an approved drug used in the treatment of heartburn and peptic ulcers, is a potent histamine congener that competitively inhibits the binding of histamine to histamine H2 receptors.
V1230	Ciproxifan (FUB-359)	184025-18-1	Ciproxifan (FUB 359; FUB-359; FUB359) is a highly potent and selective histamine H3-receptor antagonist used for treatment of cognitive deficiencies and other disorders of the central nervous system.
V1207	Clemastine Fumarate (HS592; Meclastine)	14976-57-9	Clemastine Fumarate (HS-592; HS 592 fumarate; Meclastine), the fumarate salt of clemastine, is afirst-generation H1 histamine antagonist with anticholinergic and sedative adverse effects.
V3412	Clemizole	442-52-4	Clemizole (also known as AL 20, P 48, and/or Reactrol), is a potent inhibitor of transient receptor potential channel TRPC5 (Canonical transient receptor potential channel 5) and also an H1 histamine receptor antagonist.