Aurora Kinase

Aurora Kinase

The Aurora kinases comprise a family of evolutionary conserved serine/threonine kinases (Aurora-A, Aurora-B, and Aurora-C).Aurora kinases regulate a variety of cell cycle-related processes and are necessary for the assembly and operation of the bipolar spindle during the mitotic and meiotic phases.

While Aurora-A, Aurora-B, and Aurora-C have very similar subcellular localizations and functions during mitosis, they also share a highly conserved kinase domain. While Aurora-B and Aurora-C are necessary for condensation, attachment to kinetochores, and alignment of chromosomes during (pro-)metaphase and cytokinesis, Aurora-A primarily regulates centrosome maturation and bipolar spindle assembly. All Aurora kinase members play oncogenic roles related to their mitotic activity and support the survival and growth of cancer cells in human tumors. Researchers studying cancer have become interested in inhibitors that target Aurora kinases.

Aurora Kinase related products

Structure Cat No. Product Name CAS No. Product Description
V0343 Alisertib (MLN8237, MLN-8237) 1028486-01-2 Alisertib (also named as MLN8237, MLN-8237) is a novel potent, selective, orally bioavailableAurora A kinase (AAK) inhibitor with potential antitumor activity.
V0365 AMG-900 945595-80-2 AMG 900 (AMG-900), a phtha-lazinamine compound,is a novel and ATP-competitive pan-Aurora (A/B/C) kinase inhibitor with potential antitumor activity.
V0345 Barasertib ( INH-34; AZD-1152-HQPA) 722544-51-6 Barasertib (INH34; AZD1152 or AZD1152-HQPA) is a novel, potent, highly selective, orally bioavailable small-molecule Aurora B inhibitor with potential antitumor activity.
V0350 BI-847325 1207293-36-4 BI-847325 (BI847325) is a novel, potent, orally bioavailable, and selective dual inhibitor of MEK (mitogen-activated protein kinase kinase) and Aurora kinase with potential antitumor activity.
V0359 CCT129202 942947-93-5 CCT129202 (CCT-129202), animidazopyridine compound,is a potent andATP-competitive pan-Aurora inhibitor with potential antitumor activity.
V0356 CCT137690 1095382-05-0 CCT137690 is a novel, potent, highly selective andorally bioavailable inhibitor of Aurora kinase A/B/C with potential antitumor activity.
V0364 CYC116 693228-63-6 CYC116 is a novel, potent, orally bioavailable inhibitor of Aurora A/B/C kinases with potential antitumor activity.
V0348 Danusertib (PHA739358) 827318-97-8 Danusertib (formerly PHA-739358), apyrrolo-pyrazole compound,is a potent Aurora kinase inhibitor of Aurora A/B/C with potential antitumor activity.
V0363 ENMD-2076 934353-76-1 ENMD-2076 (ENMD2076) is a novel,potent andorally bioactive inhibitor of multikinase including Aurora A and Flt3 with potential antitumor activity.
V0355 GSK1070916 (NMI900 or GSK1070916 A) 942918-07-2 GSK1070916 (also known as NMI-900 or GSK-1070916A)is a novel, potent, reversible and ATP-competitive inhibitor of Aurora B/C with potential antitumor activity.
V0361 Hesperadin 422513-13-1 Hesperadin is a novel, potent and ATP-competitive inhibitor of human aurora B kinase with potential antitumor activity.
V0354 JNJ-7706621 443797-96-4 JNJ-7706621 (JNJ7706621) is novel and potent pan-CDK (cyclin-dependent kinases) inhibitor and also an Aurora-A and Aurora-B inhibitor with potential antitumor activity.
V0353 KW-2449 1000669-72-6 KW-2449 (KW2449) is a novel, potent, multiple-kinase (e.
V0357 MK-5108 (VX689) 1010085-13-8 MK-5108 (also known as VX-689)is a novel, specific and ATP-competitive inhibitor of Aurora A kinase with potential anticancer activity.
V0352 MK-8745 885325-71-3 MK-8745 is a novel, potent, specific and selective Aurora A inhibitor with potential antitumor activity.
V0347 MLN8054 869363-13-3 MLN-8054 (MLN8054), abenzazepine-based compound, is a selective, and ATP-competitive inhibitor of Aurora A kinase (AAK) with potential antitumor activity.
V0366 PF-03814735 942487-16-3 PF-03814735 (PF03814735) is a reversible,orally bioavailable, and ATP-competitive inhibitor of Aurora A/B kinases with potential antitumor activity.
V0360 PHA-680632 398493-79-3 PHA-680632 (PHA680632) is a novel and potent pan-aurora kinase inhibitor with potential antitumor activity.
V3115 SNS-314 1057249-41-8 SNS-314 (SNS314) is a novel, potent and selective, synthetic small molecule inhibitor of Aurora A/B/C with anticancer activity.
V0367 SNS-314 Mesylate 1146618-41-8 SNS-314 mesylate, the mesylate salt ofSNS314, is a pan-Aurora kinase inhibitor with potential antineoplastic activity.
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