Calcitonin-receptor-like receptor (CRLR), a type II (family B) G-protein-coupled receptor, and receptor-activity-modifying protein 1 (RAMP1), a single-membrane-pass protein, combine to form the CGRP receptor. Both CGRP binding and CLR cell-surface expression require RAMP1. A GPCR from family B is the CLR.
The trigeminal system produces large amounts of the neuropeptide CGRP, which is also widely expressed in the peripheral and central nervous systems. Vasodilation, the perception of painful stimuli, and inflammation are just a few of the roles that CGRP plays. Through interactions with its receptors, CGRP brings about biological effects. The CGRP-A and CGRP-B subtypes of CGRP receptors exist.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V121916 | (R)-CTR/AMYR activator-1 | 3068778-30-0 | (R)-CTR/AMYR activator-1 is a CTR/AMYR activator with EC50 values of 0.8 and 0.73 nM. |
|
V77286 | Adrenomedullin (1-50), rat | Adrenomedullin (1-50), rat is a 50-amino-acid polypeptide that induces arterial vasodilation by activating the CGRP1 receptor. | |
|
V77824 | Adrenomedullin (16-31), human TFA | Adrenomedullin (16-31), human TFA is the 16-31 amino acid (AA) fragment of human adrenomedullin (hADM). | |
|
V71610 | Adrenotensin (human) (Pro-ADM-153-185 (human)) | 166546-72-1 | Adrenotensin (human) (Pro-ADM-153-185 (human)) is the 153-185 fragment of the adrenotensin (Adrenotensin) precursor peptide. |
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V114582 | Adrenotensin (human) TFA | Human adrenaline (Pro-ADM-153-185 (human)) TFA is the 153-185 fragment of the adrenaline precursor peptide. | |
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V110943 | Amylin agonist 1 | Amylin agonist 1 (Example 239a) is an islet amyloid receptor 3 (AMY3R) agonist with an EC50 of 6.17 nM that can stimulate intracellular cAMP production. | |
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V128800 | AMYR/CTR agonist 1 | 3097592-82-7 | AMYR/CTR agonist 1 is an amylin receptor and calcitonin receptor (AMYR/CTR) agonist with EC50 values of 99.5 pM and 6.16 pM for amylin receptor and calcitonin receptor cAMP, respectively. |
|
V130119 | BGM1812 | BGM1812 is a dual agonist that can simultaneously activate the amyloid receptor (hAMY3R) (EC50 = 0.627 nM) and the calcitonin gene-related peptide receptor (hCTR) (EC50 = 2.27 nM). | |
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V116154 | BMS-846372 | 1190363-03-1 | BMS-846372 (compound 5) is an orally effective CGRP antagonist (Ki = 0.07 nM). |
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V77174 | Cagrilintide acetate | Cagrilintide acetate is a non-selective AMYR/CTR agonist and long-acting acylating amylase analog. | |
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V86578 | Calcitonin (salmon) (acetate) | 158000-61-4 | Calcitonin (salmon) (acetate) is the acetate form of calcitonin salmon. |
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V77172 | Calcitonin Gene Related Peptide (CGRP) II, rat TFA | Calcitonin Gene Related Peptide (CGRP) II, rat TFA, an activator of CGRP receptors, is a potent and long-lasting vasodilator. | |
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V130951 | Calcitonin Gene Related Peptide II (rat) TFA | Calcitonin Gene Related Peptide II (rat) TFA is a potent and long-lasting vasodilator. | |
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V106116 | Calcitonin-13C6,15N4 (salmon) TFA | Calcitonin-13C6,15N4 (Salmon) (Salmon Calcitonin-13C6,15N4) TFA is 13C and 15N labeled calcitonin (Salmon). | |
|
V96718 | CGRP antagonist 6 | CGRP antagonist 6 (Compound 23) is a CGRP receptor antagonist (Ki: 0.84 nM). | |
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V131447 | CGRP antagonist 7 | 2173508-07-9 | CGRP antagonist 7 is a potent calcitonin gene-related peptide receptor (CGRP) antagonist with a Ki value of 0.029 nM. |
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V131448 | CGRP antagonist-8 | 1610413-85-8 | CGRP antagonist-8 is a CGRP receptor antagonist with an IC50 of 2.7 nM. |
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V131449 | CGRP antagonist-9 | 1610413-84-7 | CGRP antagonist-9 is a CGRP receptor antagonist with an IC50 of 25 nM. |
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V51239 | Chrysin 6-C-glucoside 8-C-arabinoside | 185145-34-0 | Chrysin 6-C-glucoside 8-C-arabinoside inhibits the release of CGRP and the activation of TRPV1 channels. |
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V132037 | Colulintide | 2891912-36-8 | Colulintide is an amylin-calcitonin dual receptor agonist with an amylin backbone. |
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