Chk

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

+MORE

Chk

Two cell cycle surveillance systems, the DNA damage checkpoint and the spindle checkpoint, protect against genomic instability. The DNA-damage checkpoint is made up of three components: DNA repair, apoptosis, and the DNA damage checkpoint kinases CHK1 and CHK2. Mad1, Mad2, Mad3(BubR1), Bub3, and the kinases Bub1, Mph1(Mps1), and Aurora B are parts of the spindle checkpoint.

When cells experience DNA damage, the checkpoint kinases CHK1 and CHK2 become active. These kinases send signals to start DNA repair procedures, regulate cell cycle progression, and stop cell replication until the damaged DNA is repaired.

When kinetochore-microtubules separate during mitosis, the spindle checkpoint causes metaphase arrest. The mitotic checkpoint complex, which is made up of Mad2, Bub3, BubR1, and Cdc20, serves as the mitotic checkpoint complex's "signal transducer" in the SAC. The anaphase promoting complex/cyclosome (APC/C) serves as the SAC's "effector."

Chk related products

Cat No.	Product Name	CAS No.	Product Description
V1584	MK-8776 (SCH 900776)	891494-63-6	MK-8776 (also known as SCH900776;MK8776;SCH-900776;MK 8776) is a novel, highly potent and selective Chk1 (cell cycle checkpoint kinase 1) inhibitor with potential antineoplastic, radiosensitization and chemosensitization activities.
V1582	AZD7762	860352-01-8	AZD7762 (AZD-7762; AZD 7762) is a selective and ATP-competitive inhibitor of Chk1 (checkpoint kinases) with potential anticancer activity.
V54441	CBP501 Affinity Peptide	1351804-17-5	CBP501 Affinity Peptide is a Chk kinase inhibitor that abolishes G2 arrest induced by DNA damaging agents.
V5293	CCT-241533 HCl	1431697-96-9	CCT241533 HCl, the dihydrochloride salt of CCT-241533, is a novel, potent and selective CHK2 inhibitor with anticancer activity.
V52290	CCT241533 dihydrochloride	1962925-28-5	CCT241533 diHCl is a potent and specific CHK2 inhibitor (antagonist) with IC50 and Ki of 3 nM and 1.16 nM respectively.
V17742	CCT244747	1404095-34-6	CCT-244747 is a novel, potent, highly selective and orally bioavailable ATP-competitive CHK1 inhibitor (IC50= 7.7 nM) with potential anticancer activity.
V2732	CCT245737	1489389-18-5	CCT245737 (CCT-245737) is a novel, potent, orally bioavailable and selective ATP-competitive inhibitor of CHK1 (checkpoint kinase 1) with anticancer activity.
V1585	CHIR-124	405168-58-3	CHIR-124 (CHIR124; CHIR 124) is a novel, potent and selective quinolone-based small molecule Chk1 (Checkpoint kinase1) inhibitor with potential anticancer activity.
V52257	Chk1-IN-5	2120398-39-0	Chk1-IN-5 is a potent checkpoint kinase 1 (Chk1) inhibitor.
V54449	Chk1-IN-6	2428423-77-0	Chk1-IN-6 is a potent, selective and orally bioavailable CHK1 inhibitor candidate.
V88618	CHK1-IN-9		CHK1-IN-9 (compound 11) is an orally active CHK1 inhibitor with an IC50 of 0.55 nM.
V3119	Chk2 Inhibitor II (BML-277)	516480-79-8	Chk2 Inhibitor II (also known as BML-277) is an ATP-competitive inhibitor of Chk2 (checkpoint kinase 2) with an IC50 of 15 nM.
V88623	Chk2-IN-2	2984543-29-3	Chk2-IN-2 (compound 2) is a selective inhibitor of CHK2 with potential anticancer activity.
V54450	Chktide	289652-77-3	Chktide is a substrate of CHK1 and CHK2.
V88622	FLT3/CHK1-IN-2		FLT3/CHK1-IN-2 (Compound 30) is a dual inhibitor of FLT3 and CHK1, with IC50 values of 25.63, 16.39, and 22.80 nM for CHK1, FLT3-WT, and FLT-D835Y, respectively.
V3690	GDC-0575 (ARRY-575, RG7741)	1196541-47-5	Chk2 Inhibitor II (also known as BML-277) is an ATP-competitive inhibitor of Chk2 (checkpoint kinase 2) with an IC50 of 15 nM.
V3691	GDC-0575 2HCl	1657014-42-0	GDC-0575 (also called ARRY-575, RG7741) is a novel, potent and selective inhibitor of CHK1 (Check point kinases) which specifically binds to and inhibits CHK1 with an IC50 of 1.2 nM.
V88620	K1586		K1586 is an amidine derivative that effectively targets Chk1.
V1586	PF-477736 (PF-00477736)	952021-60-2	PF-477736 (also known as PF-736; PF-00477736; PF477736) is a novel, selective, potent and ATP-competitive Chk1 inhibitor with potential antitumor activity.
V88621	Phosphorylated CHKtide		Phosphorylated CHKtide is a synthetic peptide substrate derived from CDC25C, which is phosphorylated by CHK1/CHK2 in one of the DNA repair pathways.