PKC

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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PKC

Protein kinase C, or PKC, is a family of enzymes that phosphorylates the hydroxyl groups of serine and threonine amino acid residues on proteins to regulate the activity of other proteins. Signals like an increase in the concentration of calcium ions (Ca2+) or diacylglycerol (DAG) can also activate PKC enzymes. PKC enzymes thus play crucial roles in a number of signal transduction cascades.The PKC family consists of 15 isozymes in humans: PKC-α (PRKCA), PKC-β1 (PRKCB), PKC-β2 (PRKCB), PKC-γ (PRKCG), PKC-δ (PRKCD), PKC-δ1 (PRKD1), PKC-δ2 (PRKD2), PKC-δ3 (PRKD3), PKC-ε (PRKCE), PKC-η (PRKCH), PKC-θ (PRKCQ), PKC-ι (PRKCI), PKC-ζ (PRKCZ), PK-N1 (PKN1), PK-N2 (PKN2), PK-N3 (PKN3). PKC participates in the desensitization of receptors, modulation of membrane structure events, transcriptional regulation, mediating immune responses, control of cell growth, learning, and memory. Other proteins are phosphorylated to carry out these functions by PKC.

PKC related products

Cat No.	Product Name	CAS No.	Product Description
V56115	(Rac)-Anemonin ((Rac)-Pulsatilla camphor; (Rac)-Anemonine)	90921-11-2	(Rac)-Anemonin ((Rac)-Pulsatilla camphor) is a diastereomer of Anemonin , a selective iNOS inhibitor and a PKC-θ inhibitor.
V52831	(S)-Ro 32-0432	1781828-85-0	(S)-Ro 32-0432 is a specific, ATP-competitive and orally bioactive PKC inhibitor (antagonist) with IC50s of 9.3 nM and 28 nM for PKCα, PKCβI, PKCβII, PKCγ and PKCε respectively.
V52844	(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol)	2442-61-7	(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) is a PKC activator.
V50967	1-Oleoyl-2-acetyl-sn glycerol	86390-77-4	1-Oleoyl-2-acetyl-sn glycerol is a synthetic, cell-penetrating/penetrable diacylglycerol analog.
V56109	6-Deoxyisojacareubin	26486-92-0	6-Deoxyisojacareubin is a PKC inhibitor that suppresses the proliferation/growth of QGY-7703 cells in a concentration-dependent manner.
V52476	7-Oxostaurosporine	125035-83-8	7-Oxostaurosporine is a potent protein kinase C (PKC) inhibitor that can effectively inhibit tumor growth by inducing apoptosis and inhibiting the nuclear factor (NF)-κB/p-p65 pathway.
V56114	[Ala107]MBP(104-118)	99026-77-4	[Ala107]MBP(104-118) is a noncompetitive peptide inhibitor of protein kinase C (PKC) with IC50s in the range of 46-145 μM.
V77668	[Ala107]MBP(104-118) TFA		[Ala107]MBP(104-118) TFA is a noncompetitive peptide inhibitor of protein kinase C (PKC) with IC50s in the range of 46-145 μM.
V56112	[Ala113]MBP(104-118)	99026-78-5	[Ala113]MBP(104-118) is a noncompetitive peptide inhibitor of protein kinase C (PKC) with IC50s in the range of 28-62 μM.
V77669	[Ala113]MBP(104-118) TFA		[Ala113]MBP(104-118) TFA is a noncompetitive peptide inhibitor of protein kinase C (PKC) with IC50s in the range of 28-62 μM.
V56111	Ac-MBP (4-14) Peptide	138250-62-1	Ac-MBP (4-14) Peptide is an acetylated MBP (4-14) Peptide.
V56105	AJH-836	388621-67-8	AJH-836 is an activator of Munc13-1 and PKC ε/α (Kd: 4.5 nM PKCα).
V52403	Aprinocarsen sodium (ISIS 3521 sodium)	331257-53-5	Aprinocarsen (ISIS 3521) sodium is a specific antisense oligonucleotide inhibitor of protein kinase C-α (PKC-α).
V52958	Bisindolylmaleimide III	137592-43-9	Bisindolylmaleimide III is a potent and specific protein kinase C (PKC) inhibitor.
V52339	Bisindolylmaleimide XI hydrochloride (Ro 32-0432; Ro 31-8830 hydrochloride)	145333-02-4	Bisindolylmaleimide XI HCl (Ro 32-0432) is a specific and orally bioactive PKC inhibitor (antagonist) with IC50s of 9 nM, 28 nM, 31 nM, 37 nM and 108 for PKCα, PKCβI, PKCβII and PKCγ respectively.
V52317	Bryostatin 3	143370-84-7	Bryostatin 3, a macrolide, is a protein kinase C activator with a Ki of 2.75 nM.
V52307	C8 Dihydroceramide	145774-33-0	C8 Dihydroceramide is the negative control (NC) for C8 Ceramide.
V52294	CC-90005	1799574-70-1	CC-90005 is a specific and orally bioactive protein kinase C-theta (PKC-theta) inhibitor (antagonist) with IC50 of 8 nM.
V88912	CIDD-0072424	1620195-03-0	CIDD-0072424 selectively inhibits protein kinase C-epsilon (PKCε) in the central nervous system (Ki=54 nM).
V77094	Delcasertib hydrochloride (KAI-9803 hydrochloride; BMS-875944 hydrochloride)		Delcasertib (KAI-9803) HCl is a specific inhibitor of delta protein kinase C (delta PKC).