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PKC

PKC

Protein kinase C, or PKC, is a family of enzymes that phosphorylates the hydroxyl groups of serine and threonine amino acid residues on proteins to regulate the activity of other proteins. Signals like an increase in the concentration of calcium ions (Ca2+) or diacylglycerol (DAG) can also activate PKC enzymes. PKC enzymes thus play crucial roles in a number of signal transduction cascades.The PKC family consists of 15 isozymes in humans: PKC-α (PRKCA), PKC-β1 (PRKCB), PKC-β2 (PRKCB), PKC-γ (PRKCG), PKC-δ (PRKCD), PKC-δ1 (PRKD1), PKC-δ2 (PRKD2), PKC-δ3 (PRKD3), PKC-ε (PRKCE), PKC-η (PRKCH), PKC-θ (PRKCQ), PKC-ι (PRKCI), PKC-ζ (PRKCZ), PK-N1 (PKN1), PK-N2 (PKN2), PK-N3 (PKN3). PKC participates in the desensitization of receptors, modulation of membrane structure events, transcriptional regulation, mediating immune responses, control of cell growth, learning, and memory. Other proteins are phosphorylated to carry out these functions by PKC.

PKC related products

Structure Cat No. Product Name CAS No. Product Description
(Rac)-Anemonin ((Rac)-Pulsatilla camphor; (Rac)-Anemonine) V56115 (Rac)-Anemonin ((Rac)-Pulsatilla camphor; (Rac)-Anemonine) 90921-11-2 (Rac)-Anemonin ((Rac)-Pulsatilla camphor) is a diastereomer of Anemonin , a selective iNOS inhibitor and a PKC-θ inhibitor.
(S)-Ro 32-0432 V52831 (S)-Ro 32-0432 1781828-85-0 (S)-Ro 32-0432 is a specific, ATP-competitive and orally bioactive PKC inhibitor (antagonist) with IC50s of 9.3 nM and 28 nM for PKCα, PKCβI, PKCβII, PKCγ and PKCε respectively.
(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) V52844 (±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) 2442-61-7 (±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) is a PKC activator.
1-Oleoyl-2-acetyl-sn glycerol V50967 1-Oleoyl-2-acetyl-sn glycerol 86390-77-4 1-Oleoyl-2-acetyl-sn glycerol is a synthetic, cell-penetrating/penetrable diacylglycerol analog.
6-Deoxyisojacareubin V56109 6-Deoxyisojacareubin 26486-92-0 6-Deoxyisojacareubin is a PKC inhibitor that suppresses the proliferation/growth of QGY-7703 cells in a concentration-dependent manner.
7-Oxostaurosporine V52476 7-Oxostaurosporine 125035-83-8 7-Oxostaurosporine is a potent protein kinase C (PKC) inhibitor that can effectively inhibit tumor growth by inducing apoptosis and inhibiting the nuclear factor (NF)-κB/p-p65 pathway.
[Ala107]MBP(104-118) V56114 [Ala107]MBP(104-118) 99026-77-4 [Ala107]MBP(104-118) is a noncompetitive peptide inhibitor of protein kinase C (PKC) with IC50s in the range of 46-145 μM.
[Ala107]MBP(104-118) TFA V77668 [Ala107]MBP(104-118) TFA [Ala107]MBP(104-118) TFA is a noncompetitive peptide inhibitor of protein kinase C (PKC) with IC50s in the range of 46-145 μM.
[Ala113]MBP(104-118) V56112 [Ala113]MBP(104-118) 99026-78-5 [Ala113]MBP(104-118) is a noncompetitive peptide inhibitor of protein kinase C (PKC) with IC50s in the range of 28-62 μM.
[Ala113]MBP(104-118) TFA V77669 [Ala113]MBP(104-118) TFA [Ala113]MBP(104-118) TFA is a noncompetitive peptide inhibitor of protein kinase C (PKC) with IC50s in the range of 28-62 μM.
Ac-MBP (4-14) Peptide V56111 Ac-MBP (4-14) Peptide 138250-62-1 Ac-MBP (4-14) Peptide is an acetylated MBP (4-14) Peptide.
AJH-836 V56105 AJH-836 388621-67-8 AJH-836 is an activator of Munc13-1 and PKC ε/α (Kd: 4.5 nM PKCα).
Aprinocarsen sodium (ISIS 3521 sodium) V52403 Aprinocarsen sodium (ISIS 3521 sodium) 331257-53-5 Aprinocarsen (ISIS 3521) sodium is a specific antisense oligonucleotide inhibitor of protein kinase C-α (PKC-α).
Bisindolylmaleimide I (GF109203X) V1526 Bisindolylmaleimide I (GF109203X) 133052-90-1 GF109203X (also known as GF109203-X; bisindolylmaleimide; GO-6850;GF-109203 X;BIMI;GF-109203X) is a novel, potent, highly selective, cell-permeable, and reversible PKC (protein kinase C) inhibitor with potential antitumor activity.
Bisindolylmaleimide III V52958 Bisindolylmaleimide III 137592-43-9 Bisindolylmaleimide III is a potent and specific protein kinase C (PKC) inhibitor.
Bisindolylmaleimide XI hydrochloride (Ro 32-0432; Ro 31-8830 hydrochloride) V52339 Bisindolylmaleimide XI hydrochloride (Ro 32-0432; Ro 31-8830 hydrochloride) 145333-02-4 Bisindolylmaleimide XI HCl (Ro 32-0432) is a specific and orally bioactive PKC inhibitor (antagonist) with IC50s of 9 nM, 28 nM, 31 nM, 37 nM and 108 for PKCα, PKCβI, PKCβII and PKCγ respectively.
Bryostatin 3 V52317 Bryostatin 3 143370-84-7 Bryostatin 3, a macrolide, is a protein kinase C activator with a Ki of 2.75 nM.
C8 Dihydroceramide V52307 C8 Dihydroceramide 145774-33-0 C8 Dihydroceramide is the negative control (NC) for C8 Ceramide.
CC-90005 V52294 CC-90005 1799574-70-1 CC-90005 is a specific and orally bioactive protein kinase C-theta (PKC-theta) inhibitor (antagonist) with IC50 of 8 nM.
Delcasertib V3529 Delcasertib 949100-39-4 Delcasertib (also known as KAI-9803 and BMS-875944)is apotent and selective δ-protein kinase C (δPKC) inhibitor that is composed of a peptide derived from the δV1-1 portion of δPKC (termed cargo peptide), conjugated reversibly to the cell-penetrating peptide 11-amino acid, arginine-rich sequence of the HIV type 1 transactivator protein (TAT₄₇₋₅₇; termed carrier peptide) via a disulfide bond.
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