Krüppel-like factor (KLF) family members share a three C2H2 zinc finger DNA binding domain, and are involved in cell proliferation and differentiation control in normal as in pathological situations.By loss of heterozygosity (LOH), somatic mutation, or transcriptional suppression by promoter hypermethylation, KLFs can become dysregulated in a variety of malignancies.
At least in part by controlling the expression of cell cycle genes, proteins belonging to the KLF family play a crucial part in the growth and metastasis of various tumor types. KLF4 and KLF6 are generally regarded as tumor suppressor genes, whereas KLF5 encourages cell division. Family members can influence each other's activity through a variety of mechanisms due to their differing transcriptional characteristics. KLF transcription factors most likely create a transcriptional network to regulate cell proliferation because cells can express multiple KLFs. When you take into account the variations in the family members' expression profiles in different cells, the effects of changes in KLF factors can seem contradictory and context-dependent. Finally, KLF variants may interfere with how proteins of the wild type function.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V18316 | CID-5951923 | 749872-43-3 | CID-5951923 (CID5951923) is a novel and potent inhibitor of Kruppel-like factor 5 (KLF5) expression (IC50 of 603 nM) with anticancer activity. |
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V4014 | ML264 | 1550008-55-3 | ML264 is a novel and selective inhibitor ofKrüppel-like factor 5 (KLF5) that potently inhibits the proliferation of colorectal cancer cells in vitro through modifications of the cell-cycle profile. |
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V4854 | SR15006 | 2505001-54-5 | SR15006 is an inhibitor (blocker/antagonist) of Kruppel-like factor 5 (KLF5) (IC50 = 41.6 nM in DLD-1 CRC cells). |
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V2972 | SR18662 | 2505001-62-5 | SR-18662 is an optimized anticancel agent based on ML264. |
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