Serine (Ser) proteases are enzymes that catalyze the hydrolysis of specific peptide bonds in their substrates, and one of the amino acids in the enzyme's active site is always a serine. The trypsin family and the subtilisin family are two families that have received particular attention in research. The process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing are just a few of the numerous cellular and extracellular functions that serine proteases are essential for. A threonine residue is present in the active site of a family of proteolytic enzymes known as thronine (Thr) proteases. Although the catalytic subunits of the proteasome are the prototype members of this class of enzymes, the active site geometry and mechanism of acyltransferases were convergently evolved.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V71868 | 3,4-Dichloroisocoumarin | 51050-59-0 | 3,4-Dichloroisocoumarin is a potent serine-protease inhibitor that can suppress chymotrypsin-like activity. |
|
V85965 | 4-Nitrophenyl 4-guanidinobenzoate hydrochloride (NPGB hydrochloride) | 19135-17-2 | |
|
V71904 | 5-O-Methylembelin | 56005-10-8 | 5-O-Methylembelin is a natural isocoumarin that can inhibit the expression of PCSK9, inducible degradation factor of low-density lipoprotein receptor (IDLR), and sterol regulatory element binding protein 2 (SREBP2) mRNA. |
|
V71900 | AAA-pNA | 60354-61-2 | AAA-pNA is a chromogenic substrate for Tripeptidyl-peptidase II. |
|
V71902 | Ac-KQL-AMC | 1104011-51-9 | Ac-KQL-AMC is a fluorogenic substrate that may be utilized to quantify trypsin-like activity, producing detectable fluorescence when cleaved by the proteasome. |
|
V93680 | Ac-Leu-Gly-Lys(Ac)MCA | 660847-06-3 | Ac-Leu-Gly-Lys(Ac)MCA is a fluorescent substrate for trypsin. |
|
V71884 | Ac-Phe-Gly-pNA | 34336-99-7 | Ac-Phe-Gly-pNA is a chymotrypsin-specific substrate. |
|
V77746 | Acetyltrypsin (acetylated trypsin) | Acetyltrypsin is a stable trypsin analogue that catalyzes the hydrolysis of α-N-benzoyl-L-argininamide. | |
|
V71874 | Ala-Phe-Pro-pNA | 201732-35-6 | Ala-Phe-Pro-pNA is the chromogenic substrate of tripeptidyl peptidase. |
|
V87719 | Anticancer agent 241 | 3030492-40-8 | Anticancer agent 241 (HZ1) is a first-in-class, orally active, specific inhibitor of cell cycle-dependent kinase-like 3 (CDKL3). |
|
V71910 | APC-6860 | 154628-42-9 | APC-6860 is a trypsin-like serine proteases inhibitor (antagonist) with Kis of 0.21 and 0.44 μM for uPA and trypsin. |
|
V4837 | Avoralstat | 918407-35-9 | Avoralstat (formerly also known as BCX-4161) is a novel, potent and orally bioavailable inhibitor of Kallikrein and Bradykinin with the potential for treatment for Hereditary angioedema. |
|
V73407 | Benzamidine hydrochloride hydrate (benzamidine hydrochloride hydrate; Benzenecarboximidamide hydrochloride hydrate) | 206752-36-5 | Benzamidine (Benzenecarboximidamide) HCl hydrate is a reversible competitive trypsin-like serine proteases inhibitor (antagonist) with Kis of 20, 21 and 21 for Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA respectively. |
|
V73401 | Berotralstat dihydrochloride (BCX7353 dihydrochloride) | 1809010-52-3 | Berotralstat di-HCl is a low-toxic, effective, specific, second-generation, orally bioactive plasma kallikrein inhibitor utilized in the research of hereditary angioedema (HAE). |
|
V78411 | Bezeparsen sodium | Bezeparsen sodium is a PCSK9 synthesis inhibitor. | |
|
V77193 | Boc-Gln-Ala-Arg-AMC acetate | Boc-Gln-Ala-Arg-AMC acetate is a trypsin fluorescent substrate. | |
|
V71889 | Boc-Gln-Ala-Arg-AMC hydrochloride | 201849-55-0 | Boc-Gln-Ala-Arg-AMC HCl is a trypsin fluorescent substrate that can also be used to measure the proteolytic activity of TMPRSS2. |
|
V71890 | Boc-QAR-pNA | 1926163-47-4 | Boc-QAR-pNA is a chromogenic substrate for trypsin. |
|
V86537 | Bradykinin acetate | 6846-03-3 | Bradykinin acetate is a potent endothelium-dependent vasodilator that lowers blood pressure. |
|
V101106 | CDKL2-IN-1 | 2471972-15-1 | CDK-IN-14 (Compound 9) is a potent and selective CDKL2 (cyclin-dependent kinase-like 2) inhibitor with IC50 of 460 nM. |
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