The 7TM receptor family A's orphan member is the Epstein-Barr virus (EBV) induced receptor 2 (EBI2; also known as GPR183). EBI2 is a seven-transmembrane receptor that is constitutively active. Different phylogenetic analyses have assigned EBI2 to various 7TM receptor subgroups as a target for peptide or lipid ligands. Extracellular signal-regulated kinase (ERK) is constitutively activated by EBI2 in a pertussis toxin-insensitive manner. Following an EBV infection, B cells exhibit a 200-fold increase in EBI2 expression.

In addition to being genetically linked to autoimmune diseases like type 1 diabetes, EBI2 activation stimulates immune cell migration. EBI2 small molecule modulators can be helpful for examining how the receptor works and how it relates to human diseases.

EBI2 related products

Structure Cat No. Product Name CAS No. Product Description
GPR183 antagonist-2 V85814 GPR183 antagonist-2 2924063-98-7
GSK682753A V3605 GSK682753A 1334294-76-6 GSK682753A is a novel, potent, and selective inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM.
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