The 7TM receptor family A's orphan member is the Epstein-Barr virus (EBV) induced receptor 2 (EBI2; also known as GPR183). EBI2 is a seven-transmembrane receptor that is constitutively active. Different phylogenetic analyses have assigned EBI2 to various 7TM receptor subgroups as a target for peptide or lipid ligands. Extracellular signal-regulated kinase (ERK) is constitutively activated by EBI2 in a pertussis toxin-insensitive manner. Following an EBV infection, B cells exhibit a 200-fold increase in EBI2 expression.
In addition to being genetically linked to autoimmune diseases like type 1 diabetes, EBI2 activation stimulates immune cell migration. EBI2 small molecule modulators can be helpful for examining how the receptor works and how it relates to human diseases.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V85814 | GPR183 antagonist-2 | 2924063-98-7 | |
|
V86596 | GPR183 antagonist-3 | GPR183 antagonist-3 (compound 33) is an orally active GPR183 antagonist with IC50 of 8.7 μM. | |
|
V86598 | GPR183-IN-1 | 2924063-70-5 | GPR183-IN-1 (compound 15) is a potent and orally active GPR183 inhibitor. |
|
V86597 | GPR183-IN-2 | 2924064-10-6 | GPR183-IN-2 (compound 23) is a potent and orally active GPR183 inhibitor. |
|
V3605 | GSK682753A | 1334294-76-6 | GSK682753A is a novel, potent, and selective inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM. |
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