FLT3

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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FLT3

FLT3 (Fms-like tyrosine kinase 3, CD135) is a protein that in humans is encoded by the FLT3 gene.The class III receptor tyrosine kinase family includes FLT3, a cytokine receptor. FLT3 is the cytokine Flt3 ligand (FLT3L)'sreceptor. On the surface of many hematopoietic progenitor cells, FLT-3 is expressed. The normal development of hemopoietic stem cells and progenitor cells depends on FLT3 signaling. One of the genes with the highest frequency of mutations in acute myeloid leukemia (AML) is FLT3.Furthermore, high FLT3 levels in blast cells from some AML patients without FLT3 mutations have been observed. The prognosis may be worse when these levels are high. Cell proliferation, differentiation, and survival are influenced by FLT3 signaling. FLT3 is crucial for the growth of lymphocytes (B and T cells), but not for the growth of other blood cells. The cytokines TNF-Alpha and TGF-Beta both inhibit FLT3 activity.

FLT3 related products

Cat No.	Product Name	CAS No.	Product Description
V77277	AKN-028 acetate		AKN-028 acetate, a novel tyrosine kinase inhibitor (TKI), is a potent orally bioactive FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor (antagonist) with IC50 of 6 nM.
V0587	AMG 925 (FLX925; AMG925)	1401033-86-0	AMG 925 (also called FLX-925; AMG-925) is a novel, potent, selective and orally bioavailable FLT3/CDK4 dual inhibitor with potential antitumor activity.
V11821	ATH686	853299-52-2	ATH686 is a novel and selective FLT3 Inhibitor.
V33217	BPR1J-097	1327167-19-0	BPR1J-097 is a novel and potent FLT3 inhibitor (antagonist) with IC50 of 11 nM.
V77188	BPR1J-097 Hydrochloride		BPR1J-097 HCl is a new and potent FLT3 inhibitor (antagonist) with IC50 of 11 nM.
V0588	Denfivontinib (G-749)	1457983-28-6	G-749 (G749) is a novel and potent FLT3 inhibitor with potential antineoplastic activity.
V69486	Emavusertib hydrochloride (CA-4948 hydrochloride)	2376399-42-5	Emavusertib (CA-4948) HCl is a selective and orally bioactive IRAK4/FLT3 inhibitor.
V78480	FLT3-IN-20		FLT3-IN-20 (compound 34f) is a potent FLT3 inhibitor (antagonist) with IC50s of 1 and 4 nM for FLT3-D835Y and FLT3-ITD, respectively.
V79168	FLT3-IN-22		FLT3-IN-22 (compound 22f) is a potent FLT3 inhibitor (antagonist) with IC50s of 0.941 nM and 0.199 nM for FLT3 and FLT3/D835Y, respectively.
V79348	FLT3-IN-23	2489528-97-2	FLT3-IN-23 is an inhibitor (blocker/antagonist) of JFMS-like tyrosine kinase 3 (FLT3) with IC50 of 7.42 nM.
V31516	FLT3-IN-3	2229050-90-0	FLT3-IN-3 is a potent FLT3 inhibitor, inhibiting FLT3 WT and FLT3 D835Y with IC50 of 13 and 8 nM, respectively.
V2632	FLT3-IN-4	2304799-09-3	FLT3-IN-4 is an orally bioavailable inhibitor of Fms-like tyrosine receptor kinase 3 (FLT3; IC50= 7 nM) for the study of acute myeloid leukemia.
V78738	HSK205	3022263-37-9	HSK205 is a dual (bifunctional) inhibitor of FLT3 and haspin, with IC50 of 0.187 nM for FLT3.
V78308	LT-850-166	3031480-22-2	LT-850-166 is a potent FLT3 inhibitor (antagonist) with the ability to overcome multiple FLT3 mutations.
V5202	MRX-2843 (UNC2371)	1429882-07-4	MRX-2843 (also known as MRX2843; UNC-2371) is a novel, potent and orally bioactivesmall-molecule inhibitor of MERTK and FLT3 with anticancer activity.
V79535	PLM-101		PLM-101 is an orally bioavailable anticancer agent targeting FLT3 and RET with inhibitory effect against acute myeloid leukemia cells.
V2881	SKLB4771	1370256-78-2	SKLB4771 (also known as FLT3-IN-1) is a novel, potent and selective inhibitor of FLT3 (fms-like tyrosine kinase 3) that may be potentially used for the treatment of cutaneous inflammation and psoriasis-like symptoms of disease.
V0589	TCS 359	301305-73-7	TCS 359 (TCS-359) is a novel, ATP-competitive and selective fms-like/FLT3 kinase inhibitor with IC50 of 42 nM.
V2549	UNC-2025	1429881-91-3	UNC-2025 is a novel,potent and orally bioavailable dualinhibitor of MER/FLT3 with IC50 of 0.74 nM and 0.8 nM, respectively, itdisplayed about 20-fold selectivity over Axl and Tyro3.
V0586	UNC-2025 HCl	2070015-17-5	UNC-2025 HCl (known also as UNC2025), the Hydrochloride salt of UNC-2025,is an orally bioavailable and selective MER/FLT3 dualinhibitor with potential antineoplastic activity.