yingweiwo
  1. Home
  2. Products
  3. Signaling Pathways
  4. PI3K / Akt / mTOR
  5. DNA-PK

DNA-PK

DNA-PK

DNA-PK (DNA-dependent protein kinase) is a nuclear serine/threonine protein kinase made up of a heterodimeric DNA-targeting subunit Ku and a large catalytic subunit (DNA-PKcs). The Nonhomologous End-Joining (NHEJ) pathway of DNA double-strand break repair contains a significant amount of DNA-PK. DNA-PK plays significant roles in the regulation of various DNA transactions, including transcription, replication, and DNA repair, as well as in the maintenance of telomeres. DNA-PK specifically requires association with DNA for its kinase activity.
Artemis, DNA ligase IV, and other NHEJ factors that are involved in end-processing and ligation are attracted to DSB ends where DNA-PK is assembled. Ku proteins act as early sensors and confer high affinities to DSB ends within the DNA-PK complex. The activation of DNA-PKcs, a member of the phosphatidylinositol 3-kinase-related kinase (PIKK) family, is caused by the subsequent recruitment of DNA-PKcs to DSBs via the Ku proteins. Several substrates, including H2AX, XRCC4, Artemis, and most importantly, DNA-PKcs itself, are phosphorylated by DNA-PKcs after it is activated. It has been demonstrated that NHEJ is mediated by DNA-PKcs autophosphorylation, which takes place at numerous Ser/Thr residues throughout the kinase.

DNA-PK related products

Structure Cat No. Product Name CAS No. Product Description
(R)-VX-984 ((R)-M9831) V52954 (R)-VX-984 ((R)-M9831) 2448475-19-0 (R)-VX-984 is the R-enantiomer of VX-984.
AZD-7648 V4344 AZD-7648 2230820-11-6 AZD-7648 (AZD7648) is a novel, potent and selectiveDNA-PK (DNA-dependent protein kinase) inhibitor with potential anticancer/antitumor activity.
BAY-8400 V52979 BAY-8400 2763602-59-9 BAY-8400 is an orally bioactive, potent and specific DNA-dependent protein kinase (DNA-PK) inhibitor (IC50=81 nM).
CC-115盐酸盐 V4345 CC-115 HYDROCHLORIDE 1300118-55-1 CC-115 hydrochloride (CC115 HCl) isa novel and potent dual inhibitor of DNA-PK (DNA-dependent protein kinase) and mTOR (mammalian target of rapamycin) withIC50s of 13 nM and 21 nM, respectively and with potential antineoplastic activity.
COMPOUND 401 V3996 COMPOUND 401 168425-64-7 Compound 401 is a potent synthetic inhibitor of DNA-dependent protein kinase (DNA-PK,IC50= 0.28 μM) that also targets mTOR but not PI3K in vitro.
DNA-PK-IN-10 V52169 DNA-PK-IN-10 2919315-89-0 DNA-PK-IN-10 is a DNA-PK inhibitor.
DNA-PK-IN-13 V88648 DNA-PK-IN-13 DNA-PK-IN-13 (Compound SK10) is a DNA-PK inhibitor that exhibits strong inhibitory activity (IC50= 0.11 nM).
DNA-PK-IN-14 V88647 DNA-PK-IN-14 2766001-96-9 DNA-PK-IN-14 (compound 78) is a potent and selective DNA-PK inhibitor with an IC50 of 7.95 nM.
DNA-PK-IN-15 V93708 DNA-PK-IN-15 2663852-17-1 DNA-PK-IN-15 (Compound 6) is an inhibitor of DNA-PK with IC50 of 0.08 nM.
DNA-PK-IN-8 (DNA-PK inhibitor DK1) V52168 DNA-PK-IN-8 (DNA-PK inhibitor DK1) 2823369-81-7 DNA-PK-IN-8 (compound DK1) is a specific and orally bioactive DNA-dependent protein kinase (DNA-PK) inhibitor (antagonist) with IC50 of 0.8 nM.
KU-0060648 V4346 KU-0060648 881375-00-4 KU0060648 (KU-0060648) is a novel, potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) with anticancer activity.
KU-0060648盐酸盐 V0254 KU-0060648 HCL KU0060648 HCl is a novel, potent and dual inhibitor of DNA-dependent protein kinase (DNA-PK) and PI3Kα/β/δ (Phosphoinositide 3-kinases) with potential antitumor activity.
LTURM-34 V24465 LTURM-34 1879887-96-3 LTURM34 is a specific DNA-PK inhibitor (IC50=34 nM).
Lys(CO-C3-p-I-Ph)-O-tBu V88646 Lys(CO-C3-p-I-Ph)-O-tBu 2703051-80-1 Lys(CO-C3-pI-Ph)-O-tBu is a pharmacokinetic modifier that can improve the PK properties of PSMA ligand molecules.
Lys(CO-C3-p-I-Ph)-OMe V88645 Lys(CO-C3-p-I-Ph)-OMe 2088426-96-2 Lys(CO-C3-pI-Ph)-OMe is a pharmacokinetic modifier that can improve the PK properties of PSMA ligand molecules (such as Ac-PSMA-trillium).
NU7026 V0253 NU7026 154447-35-5 NU7026 is a novel and potent DNA-PK (DNA-dependent protein kinase) with potential antitumor activity.
PIK-75 V3225 PIK-75 372196-67-3 PIK-75 is a p110α inhibitor with IC50 of 5.8 nM, which is 200-fold more potent than p110β.
PP121 V0200 PP121 1092788-83-4 PP-121 is a novel, potent and selective multi-targeted RTK (receptor tyrosine kinases) inhibitor with potential antitumor activity.
PP487 V88649 PP487 1092787-12-6 PP487 is a dual tyrosine kinase/PI(3)Ks inhibitor with IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM and < 0.01 μM for DNA-PK, mTOR, Hck, Src, EGFR, EphB4 and PDGFR, respectively.
YU238259 V14351 YU238259 1943733-16-1 YU238259 (YU-238259) Is a novel and potent HDR (Homology-Dependent DNA Repair) inhibitor with anticancer activity.
Contact Us
Tel: 1-708-310-1919 Fax: 1-708-557-7486 Email: sales@invivochem.com Frequently Asked Questions
Subscribe to our E-newsletter
Name
E-mail

Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved

linkedin facebook
Contact Us
Home Product Cart Member