PTEN (Phosphatase and tensin homologue deleted on chromosome 10), a phosphoinositide 3-phosphatase, is an important regulator of insulin-dependent signaling.PTEN has an anti-diabetic effect when it is lost or impaired, which raised the possibility that PTEN could be a key target for treatments for type II diabetes. The wider active site cleft of PTEN makes it possible for it to bind to the PtdIns(3,4,5)P3 substrate. a very effective and particular PTEN inhibitor that raises cellular PtdIns(3,4,5)P3 levels, phosphorylates Akt, and increases glucose uptake in adipocytes at nanomolar concentrations.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V69244 | BpV(HOpic) | 722494-26-0 | BpV(HOpic) is a potent and specific PTEN inhibitor (antagonist) with IC50 of 14 nM. |
|
V87916 | BpV(pic) potassium hydrate | 148556-27-8 | BpV(pic) potassium hydrate is a PTEN inhibitor with IC50 of 31 nM. |
|
V34222 | Ginkgolic Acid C17-1 | 111047-30-4 | Ginkgolic Acid C17-1 is natural product of the phenol class. |
|
V1912 | SF1670 | 345630-40-2 | SF1670 is a highly potent and specific PTEN inhibitor with IC50 of 2 μM. |
|
V10144 | VO-OHpic | 476310-60-8 | VO-Ohpic trihydrate is a effective PTEN inhibitor (antagonist) with IC50 of 46±10 nM. |
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