The catecholamines, in particular norepinephrine and epinephrine, are targets of the G protein-coupled receptor class known as adrenergic receptors. These receptors are found on numerous cells, and when a catecholamine binds to one of these receptors, the sympathetic nervous system is typically stimulated. The fight-or-flight response is controlled by the sympathetic nervous system, which causes the eye pupils to dilate, the body to mobilize energy, and the blood supply to skeletal muscle to be diverted from non-essential organs.There are numerous subtypes of the two main groups of adrenergic receptors, and. The receptor subtypes 1 and 2 exist. There are three subtypes of receptors: 1, 2, and 3. They are all associated with Gs proteins, which are associated with adenylate cyclase. Thus, antagonist binding increases the level of the second messenger cAMP inside of the cell. The cAMP-dependent protein kinase (PKA), one of cAMP's downstream effectors, mediates some intracellular processes after hormone binding.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V29070 | Scopine hydrochloride | 85700-55-6 | Scopine hydrochloride is the hydrochloride salt of scopine which is ametabolite of scopolamine. |
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V1111 | Silodosin (KAD 3213; KMD 3213) | 160970-54-7 | ilodosin (KMD-3213; KMD3213; KAD3213; KAD-3213; Silodosin; trade names Rapaflo, Silodal, Silodyx, Rapilif, Urief, Urorec) is a highly selective alpha1A/α1A-adrenoceptor antagonist that was approved for the treatment of BPH-benign prostatic hyperplasia. |
|
V71298 | Silodosin-d4 (silodosin d4) | 1426173-86-5 | Silodosin-d4 is the deuterated form of Silodosin. |
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V1107 | Sotalol HCl (MJ 1999) | 959-24-0 | Sotalol HCl (Betapace; Betapace AF; MJ-1999; MJ1999; Sotacor; Darob), the hydrochloride salt of Sotalol, is a competitive and non-selective β-adrenergic receptor antagonist used to treat and prevent abnormal heart rhythms. |
|
V2182 | SR-59230A oxalate | 174689-39-5 | SR-59230A oxalate (SR59230A) is a novel, potent, blood-brain barrier penetrating, and selective β3 adrenoceptor antagonist (IC50 values are 40, 408 and 648 nM for β3, β1 and β2 receptors respectively). |
|
V71337 | ST91 | 4749-61-5 | ST91 is an α2-adrenergic receptor (α2AR) agonist. |
|
V1128 | Synephrine | 94-07-5 | Synephrine [Synephrine (+/-); (+/-)-Synephrine; Oxedrine], a naturally occurring protoalkaloid found in and extracted from bitter orange and other citrus species, is commonly used for weight loss. |
|
V1139 | Synephrine HCl | 5985-28-4 | Synephrine HCl (Sympatol; oxedrine), the hydrochloride salt of synephrine which is a naturally occuring protoalkaloid extracted from bitter orange and other citrus species, is commonly used for weight loss. |
|
V4978 | Talipexole HCl | 36085-73-1 | Talipexole dihydrochloride (also known as B-HT920, Domnin, B-HT-920 dihydrochloride) is a novel and potent dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays anti-parkinsonian activity. |
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V2704 | Tamsulosin HCl | 106463-17-6 | Tamsulosin HCl, a marketed drug, is a potent and selective α1a adrenergic receptor antagonist used for the treatment ofbenign prostatic hyperplasia (BPH). |
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V71280 | Terazosin dimer impurity dihydrochloride (terazosin dihydrochloride impurity) | 1486464-41-8 | Terazosin dimer impurity di-HCl is a dimer of Terazosin and an impurity of Terazosin. |
|
V2587 | Terazosin HCl | 63074-08-8 | Terazosin HCl (A45975; A 45975; A-45975; Vasocard; Hyprin), the hydrochloride salt ofTerazosin (racemate of terazosin), is a potent and selective α1-adrenoceptor antagonist which is used for treatment of symptoms of an enlarged prostate (BPH- benign prostatic hyperplasia). |
|
V1147 | Terazosin HCl dihydrate | 70024-40-7 | Terazosin HCl dihydrate (Hytrin; A-45975; A45975), the hydrochloride salt and dihydrated form of terazosin, is a potent and selective α1-adrenoceptor antagonist with antihypertensive effects. |
|
V1123 | Terbutaline Sulfate | 23031-32-5 | Terbutaline Sulfate (Terbutaline hemisulfate; Bronclyn, Brethine, KWD-2019; KWD2019; Bricanyl, Brethaire, Terbulin) is a potent and selective β2-adrenergic receptor agonist used for the treatment of allergic asthma. |
|
V1150 | Tetrahydrozoline HCl (Tetryzoline) | 522-48-5 | Tetrahydrozoline HCl (Tetryzoline; Tyzanol; Tyzine; Vasopos; Visine) is the hydrochloride salt of terazosin, which is an imidazoline-based alpha adrenergic receptor agonist with antihypertensive activity. |
|
V71277 | Tetrahydrozoline-d4 hydrochloride (Tetryzoline-d4 (hydrochloride)) | 1246814-66-3 | Tetrahydrozoline-d4 ( HCl) is the deuterated form of Tetrahydrozoline HCl. |
|
V1124 | Timolol Maleate (L-714,465 Maleate; MK 950) | 26921-17-5 | Timolol Maleate (Optimol; Timacar; L714,465; MK-950; Betimol, Blocadren, Istalol, Timoptic), the maleate salt of timolol, is a non-selective β/beta-adrenergic receptor antagonist with antihypertensive, antiarrhythmic, antiangina, and antiglaucoma activities. |
|
V1110 | Tizanidine HCl (BRN 0618691; AB 021) | 64461-82-1 | Tizanidine HCl (AB 021 ; AN 021; DS 103-282; BRN-0618691; Sirdalud; Ternelin), the hydrochloride salt of tizanidine, is an alpha2/α2-adrenergic receptor agonist that has been approved for use mainly as a muscle relaxant to treat spasms, cramping, and tightness of muscles. |
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V71246 | Tizanidine-d4 (Tizanidine-d4) | 1188331-19-2 | Tizanidine-d4 is the deuterated form of Tizanidine. |
|
V4217 | Tolazoline | 59-98-3 | Tolazoline is a potent, non-selective competitive α-adrenergic receptor antagonist. |
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