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    Tetrahydrozoline HCl (Tetryzoline)
    Tetrahydrozoline HCl (Tetryzoline)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1150
    CAS #: 522-48-5Purity ≥98%

    Description: Tetrahydrozoline HCl (Tetryzoline; Tyzanol; Tyzine; Vasopos; Visine) is the hydrochloride salt of terazosin, which is an imidazoline-based alpha adrenergic receptor agonist with antihypertensive activity. It is used an OTC drug in the form of eye drops and nasal sprays.  

    References: Clin Toxicol (Phila). 2008 Feb;46(2):171-2.

    Related CAS #: 84-22-0 (free base)   522-48-5 (HCl)    

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    Molecular Weight (MW)236.74 
    FormulaC13H16N2.HCl 
    CAS No.522-48-5 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 12 mg/mL (50.7 mM) 
    Water: 47 mg/mL (198.5 mM)
    Ethanol: 26 mg/mL (109.8 mM) 
    Other info

    Chemical Name: 1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, hydrochloride (1:1)

    InChi Key: BJORNXNYWNIWEY-UHFFFAOYSA-N

    InChi Code: InChI=1S/C13H16N2.ClH/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13;/h1-2,4,6,12H,3,5,7-9H2,(H,14,15);1H

    SMILES Code: [H]Cl.C1(C2CCCC3=C2C=CC=C3)=NCCN1

    Synonyms

    Tetryzoline; Tyzanol; Tyzine; Vasopos; Visine. Tetrahydrozoline HCl, Tetrahydrozoline hydrochloride; 


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    In Vitro

    In vitro activity: Tetrahydrozoline HCl is an imidazoline derivative with alpha receptor agonist activity. Its main mechanism of action is the constriction of conjunctival blood vessels

    In VivoTetrahydrozoline HCl inhibits settlement of the Barnacle Balanus improvisus at 1μM 
    Animal model
    Formulation & Dosage
    References

    Clin Toxicol (Phila). 2008 Feb;46(2):171-2; J Exp Zool A Comp Exp Biol. 2005 Jul 1;303(7):551-62.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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