Size | Price | Stock | Qty |
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50mg |
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100mg |
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250mg |
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500mg |
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1g |
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2g |
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5g |
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Other Sizes |
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Purity: ≥98%
Sotalol HCl (Betapace; Betapace AF; MJ-1999; MJ1999; Sotacor; Darob), the hydrochloride salt of Sotalol, is a competitive and non-selective β-adrenergic receptor antagonist used to treat and prevent abnormal heart rhythms.
Targets |
β-adrenergic receptor; Potassium channels
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ln Vitro |
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ln Vivo |
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Animal Protocol |
20-25 g female Swiss mice
100 mg/kg Administered intraperitoneally |
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References |
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Molecular Formula |
C12H21CLN2O3S
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Molecular Weight |
308.82
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Exact Mass |
308.1
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Elemental Analysis |
C, 46.67; H, 6.85; Cl, 11.48; N, 9.07; O, 15.54; S, 10.38
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CAS # |
959-24-0
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Related CAS # |
Sotalol; 3930-20-9
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Appearance |
White to off-white solid powder
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SMILES |
CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.Cl
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InChi Key |
VIDRYROWYFWGSY-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H
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Chemical Name |
N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide;hydrochloride
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Synonyms |
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.2381 mL | 16.1907 mL | 32.3813 mL | |
5 mM | 0.6476 mL | 3.2381 mL | 6.4763 mL | |
10 mM | 0.3238 mL | 1.6191 mL | 3.2381 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
NCT05794997 | Active Recruiting |
Drug: Propranolol or Carvedilol Drug: Atenolol, Bisoprolol or Sotalol |
Hypertension | Brigham and Women's Hospital | November 30, 2022 | N/A |
NCT05418036 | Recruiting | Drug: Sotalol Oral Tablet | Proarrhythmia Ventricular Arrythmia Supraventricular Arrhythmia |
University of Sao Paulo General Hospital |
October 26, 2020 | Phase 4 |
NCT02347111 | Recruiting | Drug: Flecainide Drug: Sotalol |
Atrial Fibrillation | University of Illinois at Chicago | December 31, 2020 | Phase 4 |
NCT03799536 | Completed | Drug: Sotalol Drug: Sotalex |
Bioequivalence | Pharmtechnology LLC | January 9, 2019 | Phase 1 |
NCT00773201 | Completed | Drug: Sotalol 80 mg | Healthy Volunteers | Assistance Publique - Hôpitaux de Paris |
February 2008 | Phase 1 |
Correlation between sotalol loading doses calculated based on body weight and body surface area employing an age factor. Pediatr Cardiol . 2017 Oct;38(7):1450-1455. td> |
Correlation between sotalol maintenance doses calculated based on body weight and body surface area employing an age factor. Pediatr Cardiol . 2017 Oct;38(7):1450-1455. td> |
Effects of sotalol (SOT) on the anticonvulsant action of A. lamotrigine (LTG), B. oxcarbazepine (OXC), C. topiramate (TPM), and D. pregabalin (PGB) against maximal electroshock-induced seizures in mice. Pharmacol Rep . 2021 Apr;73(2):516-524. td> |