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    Sotalol HCl (MJ 1999)
    Sotalol HCl (MJ 1999)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1107
    CAS #: 959-24-0Purity ≥98%

    Description: Sotalol HCl (Betapace; Betapace AF; MJ-1999; MJ1999; Sotacor; Darob), the hydrochloride salt of Sotalol, is a competitive and non-selective β-adrenergic receptor antagonist used to treat and prevent abnormal heart rhythms. 

    References: J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):130-40; Pacing Clin Electrophysiol. 1995 Mar;18(3 Pt 1):451-67.

    Related CAS #: 959-24-0 (HCl)   3930-20-9 (free)  

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    Molecular Weight (MW)308.82 
    FormulaC12H20N2O3S.HCl 
    CAS No.959-24-0 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 62 mg/mL (200.8 mM) 
    Water: 62 mg/mL (200.8 mM) 
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide;hydrochloride

    InChi Key: VIDRYROWYFWGSY-UHFFFAOYSA-N

    InChi Code: InChI=1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H

    SMILES Code: CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.Cl

    SynonymsMJ 1999; sotalol Hydrochloride; Sotalol Monohydrochloride; Sotalol HCL; Betapace; Betapace AF; MJ-1999; MJ1999; Sotacor; Darob


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    In Vitro

    In vitro activity: Sotalol hydrochloride is a potent and non-selective antagonist of β-adrenergic receptor. Sotalol is also an inhibitor of potassium channels with an IC50 value of ~1.2mM in HEK cell lines.

    In VivoIn vivo, Sotalol hydrochloride has shown to lengthen atrial and ventricular monophasic action potential duration in the intact dog heart during constant atrial pacing.
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    References

    J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):130-40; Pacing Clin Electrophysiol. 1995 Mar;18(3 Pt 1):451-67.  


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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