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    Sotalol HCl (MJ 1999)
    Sotalol HCl (MJ 1999)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1107
    CAS #: 959-24-0Purity ≥98%

    Description: Sotalol HCl (Betapace; Betapace AF; MJ-1999; MJ1999; Sotacor; Darob), the hydrochloride salt of Sotalol, is a competitive and non-selective β-adrenergic receptor antagonist used to treat and prevent abnormal heart rhythms. 

    References: J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):130-40; Pacing Clin Electrophysiol. 1995 Mar;18(3 Pt 1):451-67.

    Related CAS #: 959-24-0 (HCl)   3930-20-9 (free)  

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    Molecular Weight (MW)308.82 
    FormulaC12H20N2O3S.HCl 
    CAS No.959-24-0 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 62 mg/mL (200.8 mM) 
    Water: 62 mg/mL (200.8 mM) 
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide;hydrochloride

    InChi Key: VIDRYROWYFWGSY-UHFFFAOYSA-N

    InChi Code: InChI=1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H

    SMILES Code: CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.Cl

    SynonymsMJ 1999; sotalol Hydrochloride; Sotalol Monohydrochloride; Sotalol HCL; Betapace; Betapace AF; MJ-1999; MJ1999; Sotacor; Darob


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    In Vitro

    In vitro activity: Sotalol hydrochloride is a potent and non-selective antagonist of β-adrenergic receptor. Sotalol is also an inhibitor of potassium channels with an IC50 value of ~1.2mM in HEK cell lines.

    In VivoIn vivo, Sotalol hydrochloride has shown to lengthen atrial and ventricular monophasic action potential duration in the intact dog heart during constant atrial pacing.
    Animal model
    Formulation & Dosage
    References

    J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):130-40; Pacing Clin Electrophysiol. 1995 Mar;18(3 Pt 1):451-67.  


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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