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    Terbutaline Sulfate
    Terbutaline Sulfate

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1123
    CAS #: 23031-32-5Purity ≥98%

    Description: Terbutaline Sulfate (Terbutaline hemisulfate; Bronclyn, Brethine, KWD-2019; KWD2019; Bricanyl, Brethaire, Terbulin) is a potent and selective β2-adrenergic receptor agonist used for the treatment of allergic asthma. It activates β2-adrenergic receptor with an IC50 of 53 NM, and shows little or no effect on alpha-adrenergic receptors. The drug has exerts a preferential effect on β2-adrenergic receptors but stimulates beta-adrenergic receptors less selectively than relatively selective beta2-agonists. Terbutaline inhibits antigen-induced histamine release from passively sensitized human lung tissue, which contributes to the clinical effectiveness of the drug during treatment of allergic asthma.

    References: Allergy. 1984 Jul;39(5):351-7; Int J Clin Pharmacol Ther Toxicol. 1992 Sep;30(9):342-62.

    Related CAS #: 23031-25-6 (free base)   23031-32-5 (sulfate)   

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    Molecular Weight (MW)548.65 
    FormulaC24H38N2O6.H2O4S 
    CAS No.23031-32-5  
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: <1 mg/mL
    Water: 100 mg/mL (182.3 mM)  
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: 5-(2-(tert-butylamino)-1-hydroxyethyl)benzene-1,3-diol; sulfate (2:1)

    InChi Key: KFVSLSTULZVNPG-UHFFFAOYSA-N

    InChi Code: InChI=1S/2C12H19NO3.H2O4S/c2*1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8;1-5(2,3)4/h2*4-6,11,13-16H,7H2,1-3H3;(H2,1,2,3,4)

    SMILES Code: OC1=CC(C(O)CNC(C)(C)C)=CC(O)=C1.OC2=CC(C(O)CNC(C)(C)C)=CC(O)=C2.O=S(O)(O)=O

    SynonymsKWD 2019; Terbutaline sulfate; Bronclyn, Brethine, KWD-2019; KWD2019; Bricanyl, Brethaire, Terbulin.


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    In Vitro

    In vitro activity: Terbutaline is a relatively selective β2-adrenergic bronchodilator that has little or no effect on alpha-adrenergic receptors. The drug has exerts a preferential effect on β2-adrenergic receptors but stimulates beta-adrenergic receptors less selectively than relatively selective beta2-agonists. Terbutaline inhibits antigen-induced histamine release from passively sensitized human lung tissue, which contributes to the clinical effectiveness of the drug during treatment of allergic asthma. Terbutaline also shows competitive reversible inhibition for all BChE variants. The dissociation constants for UU, FF and AA homozygotes are 0.18, 0.31 and 3.3 mM, respectively.

    In VivoTerbutaline appears to have a greater stimulating effect on beta-receptors of the bronchial, vascular, and uterine smooth muscles (β2 receptors) than on the beta-receptors of the heart (β1 receptors). This drug relaxes smooth muscle and inhibits uterine contractions, but may also cause some cardiostimulatory effects and CNS stimulation. 
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    References

    Allergy. 1984 Jul;39(5):351-7; Int J Clin Pharmacol Ther Toxicol. 1992 Sep;30(9):342-62. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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