| Size | Price | Stock | Qty |
|---|---|---|---|
| 1g |
|
||
| 2g |
|
||
| 5g |
|
||
| 10g |
|
||
| 25g |
|
||
| Other Sizes |
|
Purity: ≥98%
Terbutaline Sulfate (Terbutaline hemisulfate; Bronclyn, Brethine, KWD-2019; KWD2019; Bricanyl, Brethaire, Terbulin) is a potent and selective β2-adrenergic receptor agonist used for the treatment of allergic asthma. IIt has an IC50 of 53 NM for β2-adrenergic receptor activation, while it has negligible or no effect on alpha-adrenergic receptors. The medication preferentially affects β2-adrenergic receptors, but it stimulates beta-adrenergic receptors less selectively than beta2-agonists, which are more selectively stimulating. The clinical efficacy of terbutaline in the treatment of allergic asthma is attributed to its inhibition of antigen-induced histamine release from human lung tissue that has been passively sensitized.
| Targets |
β adrenergic receptor ( IC50 = 53 nM )
|
|
|---|---|---|
| ln Vitro |
|
|
| ln Vivo |
|
|
| Cell Assay |
Cell Line: J774 macrophages
Concentration: 0-10 μM Incubation Time: 1 hour Result: Enhanced MKP-1 expression in J774 macrophages in a dose-dependent manner. |
|
| Animal Protocol |
Adult male ob/ob mice
0.5 mg/kg Intraperitoneal injection; 0.5 mg/kg; twice a day; 20 days |
|
| References |
| Molecular Formula |
C12H20NO5S0.5
|
|
|---|---|---|
| Molecular Weight |
548.65
|
|
| Elemental Analysis |
C, 52.54; H, 7.35; N, 5.11; O, 29.16; S, 5.84
|
|
| CAS # |
23031-32-5
|
|
| Related CAS # |
Terbutaline; 23031-25-6
|
|
| Appearance |
White to off-white crystalline powder
|
|
| SMILES |
OC1=CC(C(O)CNC(C)(C)C)=CC(O)=C1.OC2=CC(C(O)CNC(C)(C)C)=CC(O)=C2.O=S(O)(O)=O
|
|
| InChi Key |
KFVSLSTULZVNPG-UHFFFAOYSA-N
|
|
| InChi Code |
InChI=1S/2C12H19NO3.H2O4S/c2*1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8;1-5(2,3)4/h2*4-6,11,13-16H,7H2,1-3H3;(H2,1,2,3,4)
|
|
| Chemical Name |
5-(2-(tert-butylamino)-1-hydroxyethyl)benzene-1,3-diol; sulfate (2:1)
|
|
| Synonyms |
|
|
| HS Tariff Code |
2934.99.9001
|
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
|
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
|
|||
|---|---|---|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 0.5 mg/mL (1.82 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 5.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 0.5 mg/mL (1.82 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 5.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 0.5 mg/mL (1.82 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 120 mg/mL (437.45 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8227 mL | 9.1133 mL | 18.2266 mL | |
| 5 mM | 0.3645 mL | 1.8227 mL | 3.6453 mL | |
| 10 mM | 0.1823 mL | 0.9113 mL | 1.8227 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT04973345 | Recruiting | Drug: Terbutaline | Asthma | Kanecia Obie Zimmerman | July 7, 2023 | Phase 2 Phase 3 |
| NCT05494307 | Not yet recruiting | Drug: Terbutaline Drug: Danazol |
Immune Thrombocytopenia | Peking University People's Hospital |
September 1, 2022 | Phase 2 |
| NCT00185887 | Completed | Drug: Terbutaline | Fetal Distress | Stanford University | October 2003 | Not Applicable |
| NCT05326269 | Completed | Drug: Terbutaline | Nonreassuring Fetal Status | Hospital Kemaman | April 23, 2017 | Not Applicable |
| NCT01096017 | Completed | Drug: Terbutaline Turbuhaler® Drug: Salbutamol pMDI Other: pMDI placebo pMDI |
Asthma | AstraZeneca | March 2010 | Phase 3 |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
COA