Size | Price | Stock | Qty |
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25mg |
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50mg |
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100mg |
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250mg |
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500mg |
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1g |
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Other Sizes |
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Purity: ≥98%
Synephrine [Synephrine (+/-); (+/-)-Synephrine; Oxedrine], a naturally occurring protoalkaloid found in and extracted from bitter orange and other citrus species, is commonly used for weight loss. Ephedrine has been substituted with synephrine. Adverse cardiovascular reactions are suspected in products containing synephrine or bitter orange. In L6 skeletal muscle cells, synephrine can promote glucose consumption (Glut4-dependent glucose uptake) by upregulating AMPK activity, independent of insulin-stimulated PI3 kinase-Akt activity.
Targets |
β adrenergic receptor
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ln Vitro |
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ln Vivo |
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Animal Protocol |
Portal vein ligation (PVL) or bile duct ligation (BDL) rats
1 mg/kg per 12 hours Oral gavage; for 8 days |
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References |
Molecular Formula |
C9H13NO2
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Molecular Weight |
167.21
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Exact Mass |
167.09
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Elemental Analysis |
C, 64.65; H, 7.84; N, 8.38; O, 19.14
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CAS # |
94-07-5
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Related CAS # |
Synephrine hydrochloride; 5985-28-4; Synephrine hemitartrate; 16589-24-5; 614-35-7 (R-isomer)
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Appearance |
Solid powder
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SMILES |
CNCC(C1=CC=C(C=C1)O)O
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InChi Key |
YRCWQPVGYLYSOX-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C9H13NO2/c1-10-6-9(12)7-2-4-8(11)5-3-7/h2-5,9-12H,6H2,1H3
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Chemical Name |
4-[1-hydroxy-2-(methylamino)ethyl]phenol
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Synonyms |
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HS Tariff Code |
2934.99.03.00
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 5.9805 mL | 29.9025 mL | 59.8050 mL | |
5 mM | 1.1961 mL | 5.9805 mL | 11.9610 mL | |
10 mM | 0.5981 mL | 2.9903 mL | 5.9805 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Chemical structure of p-synephrine. Int J Med Sci . 2012;9(7):527-38. td> |
Chemical structure of m-synephrine. Int J Med Sci . 2012;9(7):527-38. td> |