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    Synephrine
    Synephrine

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1128
    CAS #: 94-07-5Purity ≥98%

    Description: Synephrine [Synephrine (+/-); (+/-)-Synephrine; Oxedrine], a naturally occurring protoalkaloid found in and extracted from bitter orange and other citrus species, is commonly used for weight loss. Synephrine has been used as an alternative to ephedrine. Products containing bitter orange or synephrine are suspected of causing adverse cardiovascular reactions. Synephrine can stimulate glucose consumption (Glut4-dependent glucose uptake) by stimulating AMPK activity, regardless of insulin-stimulated PI3 kinase-Akt activity in L6 skeletal muscle cells.

    References: Int J Med Sci. 2012;9(7):527-38; Biochem Biophys Res Commun. 2012 Feb 24;418(4):720-4.

    Related CAS #: 5985-28-4 (HCl)   16589-24-5 (tartrate)   94-07-5 (racemate)   614-35-7 (R-isomer)    

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    Molecular Weight (MW)167.21 
    FormulaC9H13NO2 
    CAS No.94-07-5 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 33 mg/mL (197.34mM)
    Water: <1 mg/mL
    Ethanol: 2 mg/mL  (12 mM) 
    Other info

    Chemical Name: (R,S)-1-(4-Hydroxyphenyl)-2-(methylamino)ethanol

    InChi Key: YRCWQPVGYLYSOX-UHFFFAOYSA-N

    InChi Code: InChI=1S/C9H13NO2/c1-10-6-9(12)7-2-4-8(11)5-3-7/h2-5,9-12H,6H2,1H3

    SMILES Code: CNCC(O)C1=CC=C(O)C=C1

    SynonymsOxedrine; Synephrine (racemate); Synephrine (+/-); (+/-)-Synephrine 


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    In Vitro

    In vitro activity: Synephrine is a compound commonly used for weight loss. Synephrine has gained significant popularity as an alternative to ephedrine. Products containing bitter orange or synephrine are suspected of causing adverse cardiovascular reactions. Synephrine can stimulate glucose consumption (Glut4-dependent glucose uptake) by stimulating AMPK activity, regardless of insulin-stimulated PI3 kinase-Akt activity in L6 skeletal muscle cells.

    In VivoSynephrine (1 mg/kg; oral gavage; for 8 days; PVL and BDL rats) significantly ameliorates the hyperdynamic state in both PVL and BDL rats. The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index are significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance are enhanced by treatment of Synephrine
    Animal modelRats
    Formulation & Dosage1 mg/kg; oral gavage
    References

    Int J Med Sci. 2012;9(7):527-38; Biochem Biophys Res Commun. 2012 Feb 24;418(4):720-4.; Jpn J Pharmacol. 2001 Feb;85(2):183-8. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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