5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1023 | Atomoxetine HCl (Tomoxetine; LY 139603) | 82248-59-7 | Atomoxetine HCl (formerly LY139603; LY-139603; Tomoxetine; Strattera; Tomoxetina; Tomoxetinum), the hydrochloride salt of Atomoxetine, is a potent and selective norepinephrine (NE) transporter/reuptate inhibitor that has been used for treating attention-deficit hyperactivity disorder (ADHD). |
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V1024 | Venlafaxine HCl (Wy 45030 HCl) | 99300-78-4 | Venlafaxine (Wy45030; Wy-45030; Effexor, Effexor XR, Lanvexin, Viepax, and Trevilor) is an arylalkanolamine-based antidepressant that has been approved for use. |
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V0986 | Trazodone HCl (AF-116;, KB-831) | 25332-39-2 | Trazodone HCl (Beneficat, KB 831, KB831, AF 1161, AF1161), the hydrochloride salt of Trazodone, is an approved antidepressant drug of the class of serotonin receptor antagonists and reuptake inhibitors (SARI) with the potential for treatment of anxiety disorders. |
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V0976 | Granisetron HCl (BRL 43694A) | 107007-99-8 | Granisetron HCl (BRL-43694; BRL43694; BRL-43694A; trade name: Kytril), an approved antiemetic drug, is a potent serotonin 5-HT3 receptor antagonist with antiemetic activity. |
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V51787 | cis-(Z)-Flupentixol dihydrochloride | 51529-01-2 | DA D1/D2 receptor antagonist |
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V0965 | Fluoxetine HCl (LY-110140) | 56296-78-7 | Fluoxetine HCl (LY-110140; Lilly-110140; Prozac, Sarafem, Animex-On, Pulvules, Eufor, Portal), the HCl salt of fluoxetine, is a potent and selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane with anti-depressant activity. |
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V0990 | Clomipramine HCl (G34586) | 17321-77-6 | Clomipramine HCl (G-34586; G34586; Trade names: Anafranil, Clomicalm), the hydrochloride salt of clomipramine which is a tricyclic antidepressant (TCA), is a potent blocker of serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) with Ki of 0.14, 54 and 3 nM, respectively. |
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V1918 | Cyclobenzaprine HCl (MK-130) | 6202-23-9 | Cyclobenzaprine HCl (also known as MK130; Flexeril), the hydrochloride salt of Cyclobenzaprine, is a potent muscle relaxant by blocking pain sensations, used as a medication for the treatment of skeletal muscle spasms and associated pain in acute musculoskeletal conditions. |
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V0972 | Vilazodone HCl (EMD 68843; SB659746A) | 163521-08-2 | Vilazodone HCl (SB659746A; SB659746-A; EMD-68843; EMD68843; Viibryd), the hydrochloride salt of Vilazodone, is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of 5-HT1A receptors with anti-depressive effects. |
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V25462 | Metoclopramide hydrochloride hydrate | 54143-57-6 | Metoclopramide HCl hydrate is a potent and selective dopamine D2 receptor antagonist. |
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V1029 | Sertraline HCl | 79559-97-0 | Sertraline HCl (formerly CP 51,974-1; CP 51974-1; CP-51,974; trade names: Sealdin; Adjuvin; Atruline; Gladem; Tatig; Tresleen; Zoloft), the hydrochloride salt of Sertraline, is a potent and marketed antidepressant drug acting as a 5-HT serotonin receptor antagonist with Ki of 13 nM. |
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V0997 | Ondansetron HCl (GR 38032; SN 307; GR-C507/75) | 99614-01-4 | Ondansetron HCl (formerly GR 38032F, GR-C507/75; SN307; GR-C507/75; GRC-50775; GR-38032; SN-307; GR38032; Zofran) is an anti-emetic drug that acts as a potent serotonin 5-HT3 receptor antagonist. |
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V19012 | Cyproheptadine HCl hydrate | 41354-29-4 | Cyproheptadine HCl hydrate is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist. |
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V0977 | Dapoxetine HCl (LY-210448 HCl) | 129938-20-1 | Dapoxetine HCl (formerly known as LY210448; LY-210448; trade name Priligy), an antidepressant, is a novel, potent, short-acting and selective serotonin reuptake inhibitor (SSRI) that has alto been used for the treatment of premature ejaculation. |
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V1028 | Naratriptan HCl (GR-85548A HCl) | 143388-64-1 | Naratriptan HCl (GR-85548A; GR85548A; Amerge; Naramig), the hydrochloride salt of naratriptan, is a triptan class of selective 5-HT₁ receptor subtype agonist used for the treatment of migraine headaches. |
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V32953 | Asenapine HCl (Org 5222 HCl) | 1412458-61-7 | Asenapine HCl (Org-5222; HSDB 8061; Saphris; Sycrest) is a potent antagonist of multiple targets including serotonin, norepinephrine, dopamine and histamine receptors. |
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V1000 | Azasetron HCl (Y-25130) | 123040-16-4 | Azasetron HCl (formerly Y 25130 HCl; Y-25130; Y25130), an approved antiemetic drug, is a potent and selective antagonist of 5-HT3 receptor with an IC50 of 0.33 nM. |
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V0992 | Amitriptyline HCl (Elavil) | 549-18-8 | Amitriptyline (Elavil; Tryptanol; Amitriptylin; Damilen; Triptanol),a tricyclic antidepressant (TCA), is an inhibitor of serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with potential anti-depressive activity. |
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V7278 | Ramosetron hydrochloride | 132907-72-3 | Ramosetron (YM060) HCl is a 5-HT3 receptor blocker (antagonist) used to study nausea and vomiting. |
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V0983 | Ziprasidone HCl (CP-88059) | 122883-93-6 | Ziprasidone (CP 88059; CP-88,059; CP-88,059-01; Geodon; Zeldox; Zipwell) HCl, the hydrochloride salt of Ziprasidone, is a novel and potent dopamine and serotonin (5-HT) receptor antagonist with antipsychotic effects. |
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