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    Atomoxetine HCl (Tomoxetine; LY 139603)
    Atomoxetine HCl (Tomoxetine; LY 139603)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1023
    CAS #: 82248-59-7 Purity ≥98%

    Description: Atomoxetine HCl (formerly LY139603; LY-139603; Tomoxetine; Strattera; Tomoxetina; Tomoxetinum), the hydrochloride salt of Atomoxetine, is a potent and selective norepinephrine (NE) transporter/reuptate inhibitor that has been used for treating attention-deficit hyperactivity disorder (ADHD). It inhibits norepinephrine (NE) transporter/reuptate with a Ki of 5 nM, and exhibits 15- and 290-fold lower affinity for human 5-HT and DA transporters. Atomoxetine was approved for the treatment of ADHD. 

    References: Neuropsychopharmacology. 2002 Nov;27(5):699-711; J Pharmacol Exp Ther. 1985 Jan;232(1):139-43.

    Related CAS: 83015-26-3 (free)

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    Molecular Weight (MW)291.82 
    FormulaC17H21NO.HCl 
    CAS No.82248-59-7 (HCl salt);
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 58 mg/mL (198.8 mM) 
    Water: 2 mg/mL (6.8 mM)
    Ethanol: 37 mg/mL (126.8 mM) 
    Other infoChemical Name: (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine hydrochloride
    InChi Key: LUCXVPAZUDVVBT-UNTBIKODSA-N
    InChi Code: InChI=1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1
    SMILES Code: CC1=CC=CC=C1O[[email protected]@H](C2=CC=CC=C2)CCNC.[H]Cl
    SynonymsLY 139603 HCl; LY-139603 HCl; Atomoxetine; LY139603 HCl; Tomoxetine; Tomoxetina; Tomoxetinum; (-)-Tomoxetine; Strattera; Tomoxetine hydrochloride; LY 139603; (R)-Tomoxetine hydrochloride


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    In Vitro

    In vitro activity: Atomoxetine is a selective norepinephrine reuptake inhibitor with Ki of 5 nM, compared with 77 and 1451 nM for binding to serotonin and dopamine transporters.

    In VivoIn microdialysis studies, atomoxetine increases extracellular (EX) levels of NE in prefrontal cortex (PFC) 3-fold, but does not alter 5-HTEX levels. Atomoxetine also increases DAEX concentrations in PFC 3-fold, but does not alter DAEX in striatum or nucleus accumbens. Atomoxetine increases Fos by 3.7-fold in PFC, but not in the striatum or nucleus accumbens. Atomoxetine selectively inhibits the presynaptic uptake of norepinephrine in adrenergic neurons in animals, and has activity in animal models of depression. 
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    References

    Neuropsychopharmacology. 2002 Nov;27(5):699-711; J Pharmacol Exp Ther. 1985 Jan

    ;


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     
    Atomoxetine HCl
    Time course of the effects of reboxetine (3 mg/kg i.p.) (A) and methylphenidate (3 mg/kg i.p.) administration (B) on extracellular monoamine levels in prefrontal cortex of freely moving rat. Neuropsychopharmacology. 2002 Nov;27(5):699-711.
     
    Atomoxetine HCl
    The effects of local perfusion of atomoxetine on extracellular monoamine levels in prefrontal cortex of freely moving rat.


    Atomoxetine HCl
    Time course of the effects of atomoxetine administration on extracellular dopamine levels in prefrontal cortex (PFC), striatum and nucleus accumbens of freely moving rat. Neuropsychopharmacology. 2002 Nov;27(5):699-711.


     

     
    Atomoxetine HCl
    Time course of the effects of control (vehicle) or atomoxetine (0.3, 1, 3 mg/kg i.p.) administration on extracellular concentrations of norepinephrine (NE) (A), dopamine (DA) (B) and serotonin (5-HT) (C) in prefrontal cortex of freely moving


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