| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
|
||
| 500mg |
|
||
| 1g |
|
||
| 2g |
|
||
| 5g |
|
||
| 10g |
|
||
| Other Sizes |
|
Purity: ≥98%
Sertraline HCl (formerly CP 51,974-1; CP 51974-1; CP-51,974; trade names: Sealdin; Adjuvin; Atruline; Gladem; Tatig; Tresleen; Zoloft), the hydrochloride salt of Sertraline, is a potent and marketed antidepressant drug acting as a 5-HT serotonin receptor antagonist with Ki of 13 nM. Sertraline binds to the serotonin transporter with an affinity of Ki=2.8 nM, making it primarily a serotonin reuptake inhibitor (SRI). Compared to NE uptake, sertraline is more selective than fluvoxamine, zimelidine, norzimelidine, fluoxetine, or chlorimipramine in inhibiting 5-HT uptake. Sertraline, in contrast to these agents, is less selective in preventing 5-HT uptake than DA uptake. Moreover, sertraline (<50 nmol/L) inhibits the reuptake of dopamine. Its action is only 10% of its potency as a monoamine reuptake inhibitor, and this is not thought to be a tight binding. Its SRI potency ranges from 1% to 10% for α1-adrenoreceptor antagonists and 5% for σ1 receptor agonists.
| Targets |
5-HT ( Ki = 13 nM )
|
|
|---|---|---|
| ln Vitro |
|
|
| ln Vivo |
|
|
| Animal Protocol |
Aromatase-knockout (Ar−/−) mice
10 mg/kg A single i.p. administration |
|
| References |
| Molecular Formula |
C17H18CL3N
|
|
|---|---|---|
| Molecular Weight |
342.69
|
|
| Exact Mass |
341.05
|
|
| Elemental Analysis |
C, 59.58; H, 5.29; Cl, 31.04; N, 4.09
|
|
| CAS # |
79559-97-0
|
|
| Related CAS # |
(±)-cis-Sertraline-d3 hydrochloride; 1217741-83-7; rel-Sertraline-d3 hydrochloride; 1330180-66-9; 79617-96-2
|
|
| Appearance |
White to off-white solid powder
|
|
| SMILES |
CN[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.Cl
|
|
| InChi Key |
BLFQGGGGFNSJKA-XHXSRVRCSA-N
|
|
| InChi Code |
InChI=1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
|
|
| Chemical Name |
(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine;hydrochloride
|
|
| Synonyms |
|
|
| HS Tariff Code |
2934.99.9001
|
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
|
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
|
|||
|---|---|---|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.30 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.30 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (7.30 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 30% PEG400+0.5% Tween80+5% Propylene glycol : 5 mg/mL |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.9181 mL | 14.5904 mL | 29.1809 mL | |
| 5 mM | 0.5836 mL | 2.9181 mL | 5.8362 mL | |
| 10 mM | 0.2918 mL | 1.4590 mL | 2.9181 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT00667121 | Active Recruiting |
Drug: sertraline hydrochloride Drug: venlafaxine Drug: gabapentin |
Breast Cancer Depression Hot Flashes |
Mayo Clinic | March 16, 2011 | N/A |
| NCT05930912 | Active Recruiting |
Drug: sertraline 50mg Drug: Duloxetine 20 MG |
PTSD OCD Grief |
Yang I. Pachankis, PhD | June 1, 2023 | N/A |
| NCT04963257 | Recruiting | Drug: sertraline fluvoxamine Drug: sertraline |
OCD | Second Affiliated Hospital, School of Medicine, Zhejiang University |
January 1, 2020 | Phase 4 |
| NCT04221997 | Recruiting | Drug: sertraline | Anxiety Disorders | University of Cincinnati | November 1, 2019 | Phase 4 |
| NCT05646693 | Recruiting | Drug: Sertraline Drug: Placebo |
SSRI Oxidative Stress Psychiatric Drugs |
University of Guadalajara | December 1, 2022 | Phase 2 |
  |
|---|
 |
  |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
COA