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    Naratriptan HCl (GR-85548A HCl)
    Naratriptan HCl (GR-85548A HCl)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1028
    CAS #: 143388-64-1Purity ≥98%

    Description: Naratriptan HCl (GR-85548A; GR85548A; Amerge; Naramig), the hydrochloride salt of naratriptan, is a triptan class of selective 5-HT₁ receptor subtype agonist used for the treatment of migraine headaches. Naratriptan was developed and marketed by GSK and is available in 2.5 mg tablets. The mechanism of action for Naratriptan is to act as a selective 5-HT1 receptor subtype agonist. Naratriptan is used for the treatment of the acute migraine attacks and the symptoms of migraine, including severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound or light.

    References: J Headache Pain. 2011 Aug;12(4):399-403.

    Related CAS: 121679-13-8 (free base); 1190021-64-7 (Naratriptan D3)

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    Molecular Weight (MW)371.93 
    FormulaC17H25N3O2S.HCl 
    CAS No.143388-64-1 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 74 mg/mL (199.0 mM)
    Water: 22 mg/mL (59.2 mM)
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: N-Methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide hydrochloride

    InChi Key: AWEZYKMQFAUBTD-UHFFFAOYSA-N

    InChi Code: InChI=1S/C17H25N3O2S.ClH/c1-18-23(21,22)10-7-13-3-4-17-15(11-13)16(12-19-17)14-5-8-20(2)9-6-14;/h3-4,11-12,14,18-19H,5-10H2,1-2H3;1H

    SMILES Code: CN1CCC(C2=CNC3=C2C=C(CCS(=O)(NC)=O)C=C3)CC1.[H]Cl

    SynonymsGR-85548A; Naratriptan HCl; Naratriptan Hydrochloride; GR 85548A; GR85548A; Amerge; Naramig; 


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    In Vitro

    In vitro activity: Naratriptan is a triptan drug marketed by GlaxoSmithKline and is used for the treatment of migraine headaches. Naratriptan is available in 2.5 mg tablets. It is a selective 5-HT1 receptor subtype agonist. Naratriptan is used for the treatment of the acute migraine attacks and the symptoms of migraine, including severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound or light.

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    Formulation & Dosage
    References

    Cephalalgia. 1997 May;17(3):145-52.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     

    Naratriptan

    The mean headache relief for sumatriptan 100 mg, placebo, and naratriptan 2.5 mg up to 4 h in one not-fully published RCT []. *p < 0.05 for difference between naratriptan versus sumatriptan. J Headache Pain. 2011 Aug;12(4):399-403. 
     

    Naratriptan

    The mean headache relief for sumatriptan 100 mg, placebo, and naratriptan 10 mg up to 4 h in one RCT []. J Headache Pain. 2011 Aug;12(4):399-403. 


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