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    Amitriptyline HCl (Elavil)
    Amitriptyline HCl (Elavil)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0992
    CAS #: 549-18-8Purity ≥98%

    Description: Amitriptyline (Elavil; Tryptanol; Amitriptylin; Damilen; Triptanol), a tricyclic antidepressant (TCA), is an inhibitor of serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with potential anti-depressive activity. It inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50s of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively.  

    References: Chem Biol. 2009 Jun 26;16(6):644-56

    Related CAS #: 549-18-8 (HCl); 50-48-6 (free base)    

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    Molecular Weight (MW)313.86 
    FormulaC20H23N.HCl 
    CAS No.549-18-8 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 63 mg/mL (200.7 mM) 
    Water: 15 mg/mL (47.8 mM)
    Ethanol: 63 mg/mL (200.7 mM) 
    Solubility (In vivo)

    Chemical Name: 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine hydrochloride

    InChi Key: KFYRPLNVJVHZGT-UHFFFAOYSA-N

    InChi Code: InChI=1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H

    SMILES Code: CN(C)CC/C=C1C2=CC=CC=C2CCC3=CC=CC=C\13.[H]Cl

    Synonymstrade names: Elavil; Amitriptylin; Tryptanol; Damilen; Triptanol; Amitriptyline HCl; Amitriptyline hydrochloride; 


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    In Vitro

    In vitro activity: Amitriptyline inhibits Forskolin-stimulated cyclic AMP accumulation with EC50 values of 16.2 μM in intact CHO/DOR cells. Amitriptyline causes a concentration-dependent stimulation of ERK1/2 and GSK-3β phosphorylation with EC50 values of 9.0 μM in CHO/DOR cells. Amitriptyline (15 μM) causes a stimulation of ERK1/2 phosphorylation in C6 cells. Amitriptyline (30 μM) inhibits Forskolin-stimulated adenylyl cyclase activity and antagonizes (−)-U50,488 inhibitory effect in rat nucleus accumbens. Amitriptyline binds the extracellular domain of both TrkA and TrkB and promotes TrkA-TrkB receptor heterodimerization. Amitriptyline (< 500 nM) promotes TrkA autophosphorylation in primary neurons and induces neurite outgrowth in PC12 cells. Amitriptyline selectively protects T17 cells from apoptosis with EC50 of 50 nM.

    In VivoAmitriptyline (15 mg/kg, i.p.) activates TrkA and TrkB receptors and significantly reduces kainic acid-triggered neuronal cell death in mice. Amitriptyline (15 mg/kg and 30 mg/kg, i.p.) dose-dependently decreases the immobility time in the forced swimming test (FST) of mice. Amitriptyline (15 mg/kg, i.p.) shows a significant 24-h rhythm in the immobility time in the forced swimming test (FST) of mice. Amitriptyline (1 mg/kg and 3 mg/kg) significantly increases the total distance travelled of mice in novel cages. Amitriptyline (10 mg/kg p.o., twice daily) considerably attenuates the hypothermic response to 8-OHDPAT and mCPP in mice. Amitriptyline (10 mg/kg p.o., twice daily) significantly reduces serotonin transporter density by approximately 20% in cortex of mice. 
    Animal modelMice
    Formulation & Dosage15, 30 mg/kg, i.p.; 10 mg/kg p.o.
    References

    Chem Biol. 2009 Jun 26;16(6):644-56. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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