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Drug-Linker Conjugates for ADC

Drug-Linker Conjugates for ADC

The components of drug-linker conjugates for antibody drug conjugates (ADCs) are a cytotoxic drug that is active and a suitable linker. These conjugates can be used to create ADCs, which are highly selective and cytotoxic agents that are targeted for cancer cells after being joined to a monoclonal antibody.

The drug units in drug-linker conjugates are tubulin inhibitors and DNA damaging agents that have antitumor activity (i.e., ADC cytotoxins or payloads). Auristatins and Maytansinoids are the most widely used tubulin inhibitors, while Duocarmycins, Pyrrolobenzodiazepines, Camptothecines, and Daunorubicins/Doxorubicines are the most frequently used DNA damaging agents in ADCs. Additionally, a variety of conventional cytotoxic agents can be used in ADCs.

Cleavable and noncleavable ADC linkers are the two categories into which the majority of those currently undergoing clinical evaluation fall. Noncleavable linkers necessitate proteolytic degradation of the antibody component of the ADC in order to release the cytotoxic molecule, whereas cleavable linkers depend on cellular processes to release the toxin.

Drug-Linker Conjugates for ADC related products

Structure Cat No. Product Name CAS No. Product Description
(1R)-Deruxtecan V76159 (1R)-Deruxtecan 2270986-87-1 (1R)-Deruxtecan is a drug linker conjugate of ADC.
(Aminooxy)acetamide-Val-Cit-PAB-MMAE V53011 (Aminooxy)acetamide-Val-Cit-PAB-MMAE 2446645-88-9 (Aminooxy)acetamide-Val-Cit-PAB-MMAE (MMAE 5) is an intermediate used in the synthesis/preparation of drug-linker conjugates for the preparation of ADCs.
(Rac)-Lys-SMCC-DM1 ((Rac)-Lys-Nε-MCC-DM1) V77364 (Rac)-Lys-SMCC-DM1 ((Rac)-Lys-Nε-MCC-DM1) (Rac)-Lys-SMCC-DM1 ((Rac)-Lys-Nε-MCC-DM1) is the racemate of Lys-SMCC-DM1.
2',3'-cGAMP-C2-PPA V54777 2',3'-cGAMP-C2-PPA 2586047-11-0 2',3'-cGAMP-C2-PPA is a cyclic dinucleotide stimulating protein of interferon genes (STING) agonist.
680C-91 V51701 680C-91 163239-22-3 TDO inhibitor
Ac-Lys-Val-Cit-PABC-MMAE formic V77295 Ac-Lys-Val-Cit-PABC-MMAE formic Ac-Lys-Val-Cit-PABC-MMAE (formic) is part of the antibody conjugate active molecule ADC.
AcLysValCit-PABC-DMAE-SW-163D V35242 AcLysValCit-PABC-DMAE-SW-163D 2411007-69-5 AcLysValCit-PABC-DMAE-SW-163D is part of the active antibody coupling molecule (drug-linker conjugates for ADC), which is made up of natural dual intercalator SW-163D and linker AcLysValCitPABC-DMAE coupling.
Amino-PEG4-GGFG-Dxd V88381 Amino-PEG4-GGFG-Dxd 2879227-88-8 Amino-PEG4-GGFG-Dxd (Compound 13-7) is a drug-linker conjugate composed of Dxd and linker, which can be used for the synthesis of ADC.
Aminocaproyl-Val-Cit-PABC-MMAE V88382 Aminocaproyl-Val-Cit-PABC-MMAE 1374407-35-8 Aminocaproyl-Val-Cit-PABC-MMAE is a drug-linker conjugate used in the synthesis of ADC.
APN-PEG5-VC-PAB-MMAE V88401 APN-PEG5-VC-PAB-MMAE APN-PEG5-VC-PAB-MMAE is the drug-linker conjugate portion of INA03, a transferrin-competitive antibody-drug conjugate targeting CD71.
ATAC21 V3218 ATAC21 2101204-23-1 ATAC21 is a linker immunostimulatory compound formed by conjugating a non-cleavable (non-degradable) maleimide-PEG4 linker containing a succinimide group to an immunostimulatory compound.
Azide-PEG4-VC-PAB-Doxorubicin V77219 Azide-PEG4-VC-PAB-Doxorubicin Azide-PEG4-VC-PAB-Doxorubicin is made up of linker Azide-PEG4-VC-PAB and toxic molecule Doxorubicin, and may be utilized to prepare antibody-drug-conjugates/ADCss.
Azido-PEG4-Val-Cit-PAB-MMAE V54765 Azido-PEG4-Val-Cit-PAB-MMAE 1869126-64-6 Azido-PEG4-Val-Cit-PAB-MMAE is part of the antibody conjugate active molecule (drug-linker conjugate for ADC).
Barzuxetan (CHX-A''-DTPA-NCS) V54800 Barzuxetan (CHX-A''-DTPA-NCS) 157380-45-5 Barzuxetan may be utilized in study/research of cancer diseases.
Bi-Mc-VC-PAB-MMAE V52994 Bi-Mc-VC-PAB-MMAE 1620837-70-8 Bi-Mc-VC-PAB-MMAE is made up of ADC linker (Fmoc-Val-Cit-PAB) and MMAE, which is a potent (tubulin) inhibitor.
Biotin-PEG7-Maleimide V76161 Biotin-PEG7-Maleimide 1898221-65-2 Biotin-PEG7-Maleimide is a biotinylation reagent that reacts with thiol (SH) groups.
Boc-Lys-PEG8-N-bis(D-glucose) V84764 Boc-Lys-PEG8-N-bis(D-glucose) 2892350-30-8
Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT V51374 Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT 2857037-70-6 drug-linker conjugate for ADC
CL2-SN-38 V34086 CL2-SN-38 1036969-20-6 CL2-SN-38 is a cleavable linker-drug conjugate used for the synthesis of antibody drug conjugates (ADC).
CL2A-SN-38 V33342 CL2A-SN-38 1279680-68-0 CL2A-SN-38, an SN-38 (topoisomerase-I inhibitor) analogue, is a peptide-based drug linker used to synthesize antibody drug conjugates (ADC).
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