Drug-Linker Conjugates for ADC

Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
GPCR & G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

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Drug-Linker Conjugates for ADC

The components of drug-linker conjugates for antibody drug conjugates (ADCs) are a cytotoxic drug that is active and a suitable linker. These conjugates can be used to create ADCs, which are highly selective and cytotoxic agents that are targeted for cancer cells after being joined to a monoclonal antibody.

The drug units in drug-linker conjugates are tubulin inhibitors and DNA damaging agents that have antitumor activity (i.e., ADC cytotoxins or payloads). Auristatins and Maytansinoids are the most widely used tubulin inhibitors, while Duocarmycins, Pyrrolobenzodiazepines, Camptothecines, and Daunorubicins/Doxorubicines are the most frequently used DNA damaging agents in ADCs. Additionally, a variety of conventional cytotoxic agents can be used in ADCs.

Cleavable and noncleavable ADC linkers are the two categories into which the majority of those currently undergoing clinical evaluation fall. Noncleavable linkers necessitate proteolytic degradation of the antibody component of the ADC in order to release the cytotoxic molecule, whereas cleavable linkers depend on cellular processes to release the toxin.

Drug-Linker Conjugates for ADC related products

Cat No.	Product Name	CAS No.	Product Description
V76159	(1R)-Deruxtecan	2270986-87-1	(1R)-Deruxtecan is a drug linker conjugate of ADC.
V53011	(Aminooxy)acetamide-Val-Cit-PAB-MMAE	2446645-88-9	(Aminooxy)acetamide-Val-Cit-PAB-MMAE (MMAE 5) is an intermediate used in the synthesis/preparation of drug-linker conjugates for the preparation of ADCs.
V77364	(Rac)-Lys-SMCC-DM1 ((Rac)-Lys-Nε-MCC-DM1)		(Rac)-Lys-SMCC-DM1 ((Rac)-Lys-Nε-MCC-DM1) is the racemate of Lys-SMCC-DM1.
V54777	2',3'-cGAMP-C2-PPA	2586047-11-0	2',3'-cGAMP-C2-PPA is a cyclic dinucleotide stimulating protein of interferon genes (STING) agonist.
V51701	680C-91	163239-22-3	TDO inhibitor
V77295	Ac-Lys-Val-Cit-PABC-MMAE formic		Ac-Lys-Val-Cit-PABC-MMAE (formic) is part of the antibody conjugate active molecule ADC.
V35242	AcLysValCit-PABC-DMAE-SW-163D	2411007-69-5	AcLysValCit-PABC-DMAE-SW-163D is part of the active antibody coupling molecule (drug-linker conjugates for ADC), which is made up of natural dual intercalator SW-163D and linker AcLysValCitPABC-DMAE coupling.
V3218	ATAC21	2101204-23-1	ATAC21 is a linker immunostimulatory compound formed by conjugating a non-cleavable (non-degradable) maleimide-PEG4 linker containing a succinimide group to an immunostimulatory compound.
V77219	Azide-PEG4-VC-PAB-Doxorubicin		Azide-PEG4-VC-PAB-Doxorubicin is made up of linker Azide-PEG4-VC-PAB and toxic molecule Doxorubicin, and may be utilized to prepare antibody-drug-conjugates/ADCss.
V54765	Azido-PEG4-Val-Cit-PAB-MMAE	1869126-64-6	Azido-PEG4-Val-Cit-PAB-MMAE is part of the antibody conjugate active molecule (drug-linker conjugate for ADC).
V54800	Barzuxetan (CHX-A''-DTPA-NCS)	157380-45-5	Barzuxetan may be utilized in study/research of cancer diseases.
V52994	Bi-Mc-VC-PAB-MMAE	1620837-70-8	Bi-Mc-VC-PAB-MMAE is made up of ADC linker (Fmoc-Val-Cit-PAB) and MMAE, which is a potent (tubulin) inhibitor.
V76161	Biotin-PEG7-Maleimide	1898221-65-2	Biotin-PEG7-Maleimide is a biotinylation reagent that reacts with thiol (SH) groups.
V51374	Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT	2857037-70-6	drug-linker conjugate for ADC
V34086	CL2-SN-38	1036969-20-6	CL2-SN-38 is a cleavable linker-drug conjugate used for the synthesis of antibody drug conjugates (ADC).
V33342	CL2A-SN-38	1279680-68-0	CL2A-SN-38, an SN-38 (topoisomerase-I inhibitor) analogue, is a peptide-based drug linker used to synthesize antibody drug conjugates (ADC).
V77113	Cys-mcMMAD		Cys-mcMMAD may be utilized to conjugate antibodies.
V54787	DBA-DM4	905449-84-5	DBA-DM4 is a drug-linker conjugate, which is connected by the linker DBA and the toxic molecule DM4.
V53086	DBCO-(PEG)3-VC-PAB-MMAE	2754384-60-4	DBCO-(PEG)3-VC-PAB-MMAE is an active molecular conjugate (drug-linker conjugate for ADC).
V76162	DBCO-PEG4-Ahx-DM1	2479378-44-2	DBCO-PEG4-Ahx-DM1 is an active molecular conjugate (ADC) consisting of the tubulin inhibitor DM1 and the linker DBCO-PEG4-Ahx.