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Drug-Linker Conjugates for ADC

Drug-Linker Conjugates for ADC

The components of drug-linker conjugates for antibody drug conjugates (ADCs) are a cytotoxic drug that is active and a suitable linker. These conjugates can be used to create ADCs, which are highly selective and cytotoxic agents that are targeted for cancer cells after being joined to a monoclonal antibody.

The drug units in drug-linker conjugates are tubulin inhibitors and DNA damaging agents that have antitumor activity (i.e., ADC cytotoxins or payloads). Auristatins and Maytansinoids are the most widely used tubulin inhibitors, while Duocarmycins, Pyrrolobenzodiazepines, Camptothecines, and Daunorubicins/Doxorubicines are the most frequently used DNA damaging agents in ADCs. Additionally, a variety of conventional cytotoxic agents can be used in ADCs.

Cleavable and noncleavable ADC linkers are the two categories into which the majority of those currently undergoing clinical evaluation fall. Noncleavable linkers necessitate proteolytic degradation of the antibody component of the ADC in order to release the cytotoxic molecule, whereas cleavable linkers depend on cellular processes to release the toxin.

Drug-Linker Conjugates for ADC related products

Structure Cat No. Product Name CAS No. Product Description
(1R)-Deruxtecan V76159 (1R)-Deruxtecan 2270986-87-1 (1R)-Deruxtecan is a drug linker conjugate of ADC.
(Aminooxy)acetamide-Val-Cit-PAB-MMAE V53011 (Aminooxy)acetamide-Val-Cit-PAB-MMAE 2446645-88-9 (Aminooxy)acetamide-Val-Cit-PAB-MMAE (MMAE 5) is an intermediate used in the synthesis/preparation of drug-linker conjugates for the preparation of ADCs.
(Rac)-Lys-SMCC-DM1 ((Rac)-Lys-Nε-MCC-DM1) V77364 (Rac)-Lys-SMCC-DM1 ((Rac)-Lys-Nε-MCC-DM1) (Rac)-Lys-SMCC-DM1 ((Rac)-Lys-Nε-MCC-DM1) is the racemate of Lys-SMCC-DM1.
(S)-DOTAGA.(SA.FAPi)2 V122163 (S)-DOTAGA.(SA.FAPi)2 2417089-06-4 (S)-DOTAGA.(SA.FAPi)2 is a radiopharmaceutical precursor that can bind to a radionuclide to form a radiopharmaceutical conjugate (RDC).
(S)-JQ-35-C6-O-Ph-C-COOH V122181 (S)-JQ-35-C6-O-Ph-C-COOH (S)-JQ-35-C6-O-Ph-C-COOH is a target protein ligand-linker conjugate that can be used to synthesize PROTACs, such as RAFKBP12.
(S)-N-(4-((3-Methoxy-4-(2-methyl-2H-1,2,3-triazol-4-yl)pyridin-2-yl)amino)-5-propionylpyridin-2-yl)spiro[2.2]pentane-1-carboxamide-d3 V122196 (S)-N-(4-((3-Methoxy-4-(2-methyl-2H-1,2,3-triazol-4-yl)pyridin-2-yl)amino)-5-propionylpyridin-2-yl)spiro[2.2]pentane-1-carboxamide-d3 3062086-74-9
1,3-Propanediol-SNS-032 V122852 1,3-Propanediol-SNS-032 1,3-Propanediol-SNS-032 is a target protein ligand and linker conjugate that can be used to synthesize PROTAC CDK9 autophagy degrader 1.
2',3'-cGAMP-C2-PPA V54777 2',3'-cGAMP-C2-PPA 2586047-11-0 2',3'-cGAMP-C2-PPA is a cyclic dinucleotide stimulating protein of interferon genes (STING) agonist.
2,3,5,6-Tetrafluorophenyl propionate-PEG3-amino-tetraxetan V123992 2,3,5,6-Tetrafluorophenyl propionate-PEG3-amino-tetraxetan 2247041-83-2 2,3,5,6-Tetrafluorophenyl propionate-PEG3-amino-tetraxetan is a chelating agent and linker conjugate that can be used in the synthesis of radiopharmaceuticals.
2-MSP-5-HA-GGFG-NH-CH2-O-CH2-CO-(5-Cl)-Exatecan V124803 2-MSP-5-HA-GGFG-NH-CH2-O-CH2-CO-(5-Cl)-Exatecan 2813269-48-4 2-MSP-5-HA-GGFG-NH-CH2-O-CH2-CO-(5-Cl)-Exatecan is a drug-linker conjugate used in antibody-drug conjugates (ADCs).
2-MSP-5-HA-VA-PAB-Exatecan V111070 2-MSP-5-HA-VA-PAB-Exatecan 2878440-72-1 2-MSP-5-HA-Val-Cit-PAB-Exatecan (A-24) is a drug-linker conjugate for antibody-drug conjugates (ADCs).
2-MSP-5-HA-VC-PAB-MMAE V114221 2-MSP-5-HA-VC-PAB-MMAE 2878440-80-1 2-MSP-5-HA-VC-PAB-MMAE (compound B-1) is an antibody-drug conjugate (ADC)-drug linker conjugate.
2-octynoic acid-BSA V124836 2-octynoic acid-BSA 2-octynoic acid-BSA is an immunogen used to establish a mouse model of primary biliary cholangitis (PBC).
4-Arm-PEG10000-Acrylamide V126194 4-Arm-PEG10000-Acrylamide 1818880-26-0
4-Arm-PEG10000-Dopamine V126197 4-Arm-PEG10000-Dopamine 1067250-10-5
4-Arm-PEG10000-Hydrazide V126201 4-Arm-PEG10000-Hydrazide 2368232-56-6
4-Arm-PEG10000-Isocyanate V126202 4-Arm-PEG10000-Isocyanate 724786-32-7
4-Arm-PEG10000-Nitrophenyl carbonate V126204 4-Arm-PEG10000-Nitrophenyl carbonate
4-Arm-PEG10000-Norbornene V126205 4-Arm-PEG10000-Norbornene
4-Arm-PEG10000-OPSS V126207 4-Arm-PEG10000-OPSS 3114600-58-4
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