| Size | Price | Stock | Qty |
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| 250mg |
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| 500mg |
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| 1g |
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| 2g |
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| 5g |
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| 10g |
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| 50g |
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Metoclopramide HCl hydrate is a potent and selective dopamine D2 receptor antagonist. This medication is primarily used to treat esophageal and stomach issues, including nausea and vomiting. It can aid in the treatment of gastroesophageal reflux disease and help those with delayed stomach emptying as a result of diabetes or surgery. It can also be used to treat migraine headaches.
| Targets |
5-HT3 Receptor ( IC50 = 308 nM ); D2 Receptor ( IC50 = 483 nM )
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|---|---|
| ln Vitro |
Metoclopramide hydrochloride hydrate (0.01-10 μM) stimulates the release of aldosterone in rat zona glomerulosa cells that have been perfused and isolated[3].
Metoclopramide hydrochloride hydrate causes prokinesis through four different mechanisms: it inhibits D2 postsynaptic receptors, stimulates presynaptic excitatory 5-HT4 receptors, and antagonizes the presynaptic inhibition of muscarinic receptors, which increases the release of acetylcholine (ACh) from intrinsic cholinergic motor neurons[2]. |
| ln Vivo |
Metoclopramide (6.7 µg/g; s.c. daily for 50 days) hydrochloride hydrate dramatically raises the pituitary gland's lactotroph cell count and volume aall stages of the estrous cycle[4].
Metoclopramide (5–40 mg/kg; intraperitoneal) hydrochloride hydrate causes catalepsy and counteracts the behavior of cage climbing induced by apomorphine in mice[5]. Metoclopramide (1.25–2.5 mg/kg; i.p.) causes a stereotyped cage-climbing behavior in mice[5]. |
| Animal Protocol |
Adult, virgin female mice of the Swiss EPM-1 strain
6.7 µg/g S.c. daily for 50 days |
| References |
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| Molecular Formula |
C14H25CL2N3O3
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|---|---|
| Molecular Weight |
354.2726
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| Exact Mass |
353.13
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| CAS # |
54143-57-6
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| Related CAS # |
Metoclopramide; 364-62-5; Metoclopramide hydrochloride; 7232-21-5
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| Appearance |
Powder
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| SMILES |
CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl.O.Cl
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| InChi Key |
KJBLQGHJOCAOJP-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C14H22ClN3O2.ClH.H2O/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3;;/h8-9H,4-7,16H2,1-3H3,(H,17,19);1H;1H2
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| Chemical Name |
4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;hydrate;hydrochloride
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| Synonyms |
Metoclopramide hydrochloride hydrate
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 50~71 mg/mL (141.1~200.4 mM)
Water: ~71 mg/mL Ethanol: ~71 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.06 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.06 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8227 mL | 14.1135 mL | 28.2271 mL | |
| 5 mM | 0.5645 mL | 2.8227 mL | 5.6454 mL | |
| 10 mM | 0.2823 mL | 1.4114 mL | 2.8227 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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