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    Venlafaxine HCl (Wy 45030 HCl)
    Venlafaxine HCl (Wy 45030 HCl)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1024
    CAS #: 99300-78-4Purity ≥98%

    Description: Venlafaxine (Wy45030; Wy-45030; Effexor, Effexor XR, Lanvexin, Viepax and Trevilor), an approved and arylalkanolamine-based antidepressant, is an serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat various disorders including major depressive disorder (MDD), panic disorder and social phobia, generalised anxiety disorder (GAD).  

    References: Br J Clin Pharmacol. 1997 Jun;43(6):619-26; Pain. 1996 Nov;68(1):151-5.

    Related CAS: 93413-69-5 (free base)

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    Molecular Weight (MW)313.86 
    FormulaC17H27NO2·HCl 
    CAS No.99300-78-4 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 55 mg/mL (176.8 mM) 
    Water: 55 mg/mL (176.8 mM) 
    Ethanol: 55 mg/mL (176.8 mM) 
    Other info

    Chemical Name: 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol hydrochloride

    InChi Key: QYRYFNHXARDNFZ-UHFFFAOYSA-N

    InChi Code: InChI=1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H

    SMILES Code: OC1(C(C2=CC=C(OC)C=C2)CN(C)C)CCCCC1.[H]Cl

    SynonymsWy-45030; Trade names: Effexor, Effexor XR, Lanvexin, Viepax and Trevilor. Wy45030; Wy 45030; 


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    In Vitro

    In vitro activity: Venlafaxine has a low potential to inhibit the metabolism of substrates for CYP2D6 such as imipramine and desipramine compared with several of the most widely used SSRIs, as well as the metabolism of substrates for several of the other major human hepatic P450s. Venlafaxine inhibits binding to the human norepinephrine (NE) and serotonin (5-HT) transporters with K(i) values of 2480 nM and 82 nM, respectively, and with a K(i) ratio of 30. Venlafaxine has ED(50) values of 5.9 mg/kg and 94 mg/kg for blocking p-chloramphetamine- and 6-hydroxydopamine-induced monoamine depletion, respectively.

    In VivoVenlafaxine induces a dose-dependent antinociceptive effect following i.p. administration with an ED50 of 46.7 mg/kg in mice. Venlafaxine-induced antinociception is significantly inhibited by naloxone, nor-BNI and naltrindole but not by beta-FNA or naloxonazine, implying involvement of kappa1- and delta-opioid mechanisms in mice. Venlafaxine reverses hyperalgesia in rats with a fully developed neuropathic lesion. Venlafaxine also appears to have a mild non-specific analgesic effect that increased paw withdrawal latency (PWL) in the sham limb. 
    Animal modelMice
    Formulation & Dosage46.7 mg/kg; i.p.
    References

    Br J Clin Pharmacol. 1997 Jun;43(6):619-26; Pain. 1996 Nov;68(1):151-5. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     
    Venlafaxine
    Behaviors of the open-field test at different time. Behav Brain Funct. 2016; 12: 34.
     

    Venlafaxine

    The sucrose preference test at different time.

    Venlafaxine


    Mean optical density for S100B protein in the hippocampus. Behav Brain Funct. 2016; 12: 34.

    Venlafaxine

     

    Mean optical density for S100B mRNA in the hippocampus.


    Venlafaxine
    S100B mRNA pictures in situ hybridization. Behav Brain Funct. 2016; 12: 34.


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