Venlafaxine HCl (Wy 45030 HCl)

Alias: Naramig; GR-85548A; Amerge; GR 85548A; GR85548A; Naratriptan HCl; Naratriptan Hydrochloride
Cat No.:V1024 Purity: ≥98%
Venlafaxine (Wy45030; Wy-45030; Effexor, Effexor XR, Lanvexin, Viepax, and Trevilor) is an arylalkanolamine-based antidepressant that has been approved for use.
Venlafaxine HCl (Wy 45030 HCl) Chemical Structure CAS No.: 99300-78-4
Product category: 5-HT Receptor
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
100mg
250mg
500mg
1g
2g
5g
10g
Other Sizes

Other Forms of Venlafaxine HCl (Wy 45030 HCl):

  • Venlafaxine-d6 hydrochloride (Wy 45030-d6 (hydrochloride))
  • Venlafaxine (Wy 45030)
  • Venlafaxine-d10 hydrochloride (venlafaxine d10 hydrochloride)
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Venlafaxine (Wy45030; Wy-45030; Effexor, Effexor XR, Lanvexin, Viepax, and Trevilor) is an arylalkanolamine-based antidepressant that has been approved for use. It is a serotonin-norepinephrine reuptake inhibitor (SNRI) that is used to treat a variety of conditions, such as generalized anxiety disorder (GAD), major depressive disorder (MDD), panic disorder, and social phobia.

Biological Activity I Assay Protocols (From Reference)
Targets
5-HT
ln Vitro

In vitro activity: Venlafaxine has a lower potential than some of the most popular SSRIs to inhibit the metabolism of CYP2D6 substrates, such as imipramine and desipramine, as well as the metabolism of substrates for several other major human hepatic P450s.[1] Human norepinephrine (NE) and serotonin (5-HT) transporters have K(i) values of 2480 nM and 82 nM, respectively, and a K(i) ratio of 30, which are inhibited by venlafaxine. For the purpose of preventing monoamine depletion caused by 6-hydroxydopamine and p-chloramphetamine, venlafaxine has ED(50) values of 94 mg/kg and 5.9 mg/kg, respectively.[2]

ln Vivo
Venlafaxine causes an i.p. administration of 46.7 mg/kg of a dose-dependent antinociceptive effect in mice. While beta-FNA and naloxonazine do not significantly inhibit venlafaxine-induced antinociception, naloxone, nor-BNI, and naltrindole do, suggesting that kappa1- and delta-opioid mechanisms are involved in mice.[3] In rats with a fully developed neuropathic lesion, ventlafaxine reverses hyperalgesia. Additionally, paw withdrawal latency (PWL) in the sham limb was found to be elevated by the mild, non-specific analgesic effect of ventralfaxine.[4]
Animal Protocol
Male Sprague-Dawley rats weighing 180-230 grams
10, 30, 100 mg/kg
IP; one hour prior to p-chloramphetamine hydrochloride (p-CA; 10 mg/kg; i.p.)
References

[1]. Br J Clin Pharmacol . 1997 Jun;43(6):619-26.

[2]. Neuropsychopharmacology . 2001 Dec;25(6):871-80.

[3]. Neurosci Lett . 1999 Oct 1;273(2):85-8.

[4]. Pain . 1996 Nov;68(1):151-155.

These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C17H28CLNO2
Molecular Weight
313.86
Exact Mass
313.18
Elemental Analysis
C, 54.90; H, 7.05; Cl, 9.53; N, 11.30; O, 8.60; S, 8.62
CAS #
99300-78-4
Appearance
Solid powder
SMILES
CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O.Cl
InChi Key
QYRYFNHXARDNFZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H
Chemical Name
1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol;hydrochloride
Synonyms
Naramig; GR-85548A; Amerge; GR 85548A; GR85548A; Naratriptan HCl; Naratriptan Hydrochloride
HS Tariff Code
2935.90.6000
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: 50~55 mg/mL (159.3~176.8 mM)
Water: ~55 mg/mL (~176.8 mM)
Ethanol: ~55 mg/mL (~176.8 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 3.1861 mL 15.9307 mL 31.8613 mL
5 mM 0.6372 mL 3.1861 mL 6.3723 mL
10 mM 0.3186 mL 1.5931 mL 3.1861 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

Calculator

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Dilution Calculator allows you to calculate how to dilute a stock solution of known concentrations. For example, you may Enter C1, C2 & V2 to calculate V1, as detailed below:

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Using the equation C1V1 = C2V2, where C1=10 mM, C2=25 μM, V2=25 ml and V1 is the unknown:
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g/mol

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Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
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In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)
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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
             (2) Be sure to add the solvent(s) in order.

Clinical Trial Information
NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00667121 Active
Recruiting
Drug: venlafaxine
Drug: tamoxifen citrate
Drug: gabapentin
Breast Cancer
Depression
Hot Flashes
Mayo Clinic March 16, 2011 N/A
NCT03532477 Recruiting Drug: Venlafaxine Obesity, Morbid Norwegian University of Science
and Technology
November 2, 2016 N/A
NCT05023278 Completed Drug: Venlafaxine 37.5 MG
Drug: Placebo
Acute Pain
Chronic Pain
Knee Pain Chronic
Neuropathic Pain
University of California,
San Francisco
May 10, 2021 Phase 4
NCT04639193 Recruiting Drug: Venlafaxine
Drug: Placebo
OSA
Obstructive Sleep Apnea
University of California, San
Diego
January 1, 2020 Phase 2
NCT04961190 Recruiting Behavioral: Prolonged Exposure
Therapy
Drug: Pharmacotherapy with
paroxetine or venlafaxine XR
Posttraumatic Stress Disorder University of Pennsylvania May 25, 2022 Phase 4
Biological Data
  • Venlafaxine
    Behaviors of the open-field test at different time.Behav Brain Funct. 2016; 12: 34.
  • Venlafaxine

    The sucrose preference test at different time.

    Venlafaxine


    Mean optical density for S100B protein in the hippocampus.Behav Brain Funct. 2016; 12: 34.
  • Venlafaxine


    Mean optical density for S100B mRNA in the hippocampus.


    Venlafaxine
    S100B mRNA pictures in situ hybridization.Behav Brain Funct. 2016; 12: 34.
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