5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1018 | Mirtazapine (Org3770; 6-Azamianserin) | 85650-52-8 | Mirtazapine (formerly Org3770, Org 3770; trade names Remeron, Avanza, Axit, Mirtazon, Zispin),an approved atypical antidepressant drug, is an adrenergic and serotonin receptor antagonist used for treating depression. |
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V4286 | MK 0893 | 870823-19-1 | MK-0893 (CRA1; MK0893) is a novel, potent and selective glucagon receptor antagonist with an IC50 of 6.6 nM. |
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V0994 | Mosapride Citrate (TAK-370; AS-4370) | 112885-42-4 | Mosapride Citrate (formerly AS-4370; TAK-370 citrate; AS-4370 citrate; TAK 370 citrate) is a novel, potent and selective gastroprokinetic agent that has been used in patients with upper gastrointestinal disorders. |
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V80839 | MRS7925 | MRS7925 (Compound 43) is a 5-HT2BR antagonist (Ki= 17 nM). | |
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V71122 | NAN-190 hydrobromide | 115338-32-4 | NAN-190 HBr is a serotonin receptor 5-HT receptor blocker (antagonist). |
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V71188 | Nantenine | 2565-01-7 | Nantenine is a serotonin receptor antagonist. |
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V1028 | Naratriptan HCl (GR-85548A HCl) | 143388-64-1 | Naratriptan HCl (GR-85548A; GR85548A; Amerge; Naramig), the hydrochloride salt of naratriptan, is a triptan class of selective 5-HT₁ receptor subtype agonist used for the treatment of migraine headaches. |
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V71217 | Naratriptan-d3 (GR-85548A-d3-1) | 1190043-69-6 | Naratriptan-d3 is the deuterium labelled form of Naratriptan. |
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V71215 | NAS-181 | 205242-62-2 | NAS-181 is a potent and specific rat serotonin 1B (r5-HT1B) antagonist (inhibitor) with a Ki of 47 nM. |
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V71121 | NAS-181 dimesylate | 1217474-40-2 | NAS181 is a potent and specific rat 5-HT1B receptor antagonist (inhibitor) with a Ki of 47 nM. |
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V26538 | NLX-101 (F-15599) | 635323-95-4 | NLX-101, formerly known as F-15599, is a G-protein biased compound that activates serotonin 5-HT1A receptors with exceptional selectivity, having over 1000-fold higher affinity for this target over other receptors. |
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V3103 | Ocaperidone (R79598) | 129029-23-8 | Ocaperidone (R-79598; R79598) is a potent and effective benzisoxazolyl piperidine neuroleptic and antipsychotic acting as an antagonist of 5-HT2, dopamine D2 and a 5-HT1A, with Ki values of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for 5-HT2, a1-adrenergic receptor, dopamine D2, histamine H1 and a2-adrenergic receptor, respectively. |
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V0963 | Olanzapine (LY170053) | 132539-06-1 | Olanzapine (formerly LY-170052, LY 170052, Zyprexa, Zolafren),a thienobenzodiazepine analog, is an approved atypical antipsychotic drug with high affinity for 5-HT2 serotonin and D2 dopamine receptor. |
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V0975 | Ondansetron (GR 38032; SN 307; GR-C507/75) | 99614-02-5 | Ondansetron (GRC-50775; GR-38032; SN-307; GR38032; SN307; GR-C507/75; Zofran), an approved antiemetic drug, is a potent serotonin 5-HT3 receptor antagonist which is used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy. |
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V0997 | Ondansetron HCl (GR 38032; SN 307; GR-C507/75) | 99614-01-4 | Ondansetron HCl (formerly GR 38032F, GR-C507/75; SN307; GR-C507/75; GRC-50775; GR-38032; SN-307; GR38032; Zofran) is an anti-emetic drug that acts as a potent serotonin 5-HT3 receptor antagonist. |
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V71163 | Ondansetron hydrochloride dihydrate (ondansetron hydrochloride dihydrate; GR 38032 hydrochloride dihydrate; SN 307 hydrochloride dihydrate) | 103639-04-9 | Ondansetron (GR 38032) HCl dehydrate is an orally bioavailable, selective and competitive 5-HT3 receptor antagonist (BBB (blood-brain barrier) permeable (penetrable)). |
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V71227 | Ondansetron-d3 (GR 38032-d3; SN 307-d3) | 1132757-82-4 | Ondansetron-d3 is the deuterium labelled form of Ondansetron. |
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V71212 | Ondansetron-d5 (GR 38032-d5; SN 307-d5) | 1219798-86-3 | Ondansetron-d5 is the deuterium labelled form of Ondansetron. |
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V71210 | Ondansetron-d6 hydrochloride (GR 38032-d6 hydrochloride; SN 307-d6 hydrochloride) | 1225442-22-7 | Ondansetron-d6 ( HCl) is the deuterium labelled form of Ondansetron HCl. |
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V71155 | Org-12962 hydrochloride | 210821-63-9 | Org 12962 HCl is a potent and specific 5-HT2C receptor agonist/activator with pEC50s of 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2B respectively. |
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