5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71216 | R-96544 free base | 167144-79-8 | R-96544 (free base) is a specific, competitive 5-HT2 receptor antagonist. |
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V83206 | R-96544 HCl | 167144-80-1 | R-96544 HCl is an orally bioactive 5-HT2A receptor antagonist, and can inhibit platelet aggregation in vitro |
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V7278 | Ramosetron hydrochloride | 132907-72-3 | Ramosetron (YM060) HCl is a 5-HT3 receptor blocker (antagonist) used to study nausea and vomiting. |
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V71165 | Renzapride (BRL 24924) | 112727-80-7 | Renzapride (BRL 24924), a substituted benzamide, is a 5-HT4 receptor agonist and a 5HT2b and 5HT3 receptor antagonist. |
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V71131 | Repinotan (BAY x 3702 free base) | 144980-29-0 | Repinotan (BAY x 3702 free base) is a specific, BBB (blood-brain barrier) permeable (penetrable), and orally bioactive 5-HT1A receptor agonist/activator with a Ki of 0.19 nM (calf hippocampus), 0.25 nM (rat and human cortex) and 0.59 nM (rat hippocampus). |
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V0982 | Risperidone (R-64766; Risperdal) | 106266-06-2 | Risperidone (R-64766; R64766 and Risperdal), an marketed atypical antipsychotic, is a potent multi-targeted antagonist for dopamine, serotonin, adrenergic and histamine receptors, it has been approved for use in the treatment of schizophrenia and bipolar disorder. |
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V29718 | Risperidone hydrochloride | 666179-74-4 | Risperidone HCl is the hydrochloride salt of Risperidone (R64766; R-64766; Risperdal), which is an approved atypical antipsychotic for the treatment of schizophrenia and bipolar disorder. |
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V13809 | Risperidone Mesylate | 666179-96-0 | Risperidone mesylate is the mesylate saltof Risperidone (R64766; Risperdal), which is an approved atypical antipsychotic and a blocker of dopamine D2 receptors as well as serotonin 5-HT2 receptors. |
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V0979 | Rizatriptan Benzoate (MK-462 Benzoate) | 145202-66-0 | Rizatriptan Benzoate (Maxalt; formerly MK 0462; MK 462)is a potent and selective agonist at serotonin 5-HT1B and 5-HT1D receptors with anti-migraine activity. |
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V4698 | Roluperidone | 359625-79-9 | Roluperidone (formerly also known as CYR-101, MIN-101, CYR101, and MT-210) is a novel and potent cyclic amide derivative with-schizophrenia effects. |
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V71167 | RS 23597-190 (EP-A-501322) | 149719-06-2 | RS 23597-190 (EP-A-501322) is a high-affinity and selective 5-HT4 receptor antagonist. |
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V0968 | RS-127445 | 199864-87-4 | RS-127445 (RS 127445; RS127445) is a novel, potent, selective, and orally bioavailable 5-HT2B receptor antagonist with important biological activity. |
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V71137 | RU 24969 hemisuccinate | 66611-27-6 | RU 24969 hemisuccinate is a preferential 5-HT1B agonist/activator with a Ki of 0.38 nM. |
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V4607 | SB 242084 HCl | 1049747-87-6 | SB-242084 HCl, the hydrochloride salt ofSB 242084, is a novel, potent and selective 5-HT2C receptor antagonist with pKi of 9.0 and with 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. |
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V71123 | SB 243213 | 200940-22-3 | SB 243213 is an orally bioactive, selective, high-affinity 5-HT2C receptor antagonist (inhibitor) with pKi of 9.37 and a pKb of 9.8 for the human 5-HT2C receptor. |
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V0984 | SB 271046 (SB-271046A) | 209481-20-9 | SB271046 (SB 271046; SB-271046; SB-271046A; SB271046A) is a novel, potent, selective and orally bioactive 5-HT6 receptor antagonist with important biological activity. |
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V0980 | SB 271046 HCl (SB-271046A) | 209481-24-3 | SB271046 HCl (SB 271046; SB-271046), the hydrochloride salt of SB 271046, is a novel, potent, selective and orally bioactive 5-HT6 receptor antagonist with potential anticonvulsant activity. |
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V71150 | SB-200646A | 143797-62-0 | SB-200646A is the first antagonist selective for 5-HT2B/2C over 5-HT2A, with pKis of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A respectively. |
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V4617 | SB-399885 HCl | 402713-81-9 | SB 399885 hydrochloride is a novel, potent, brain penetrant, and orally bioactive 5-HT6 receptor antagonist. |
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V2619 | SB269970 (SB-269970A) | 201038-74-6 | SB269970 (SB-269970A)is a novel and potent 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors. |
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