5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1032 | Lorcaserin HCl | 846589-98-8 | Lorcaserin HCl (Belviq Xr; APD-356; APD356; Lorqess), the hydrochloride salt of Lorcaserin which is a marketed weight-loss drug, is a potent and selective full agonist of human 5-HT2C (serotonin) receptor with Ki of 15 nM. |
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V1031 | Loxapine Succinate | 27833-64-3 | Loxapine Succinate (Loxapac; Adasuve; Cloxazepin; Daxolin; Oxilapine), the succinate salt ofLoxapine which is a dibenzoxazepine anti-psychotic drug, is a potent D2DR/D4DR inhibitor as well as serotonergic receptor antagonist. |
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V3191 | LP-211 | 1052147-86-0 | LP-211 is a potent and selective5-HT7receptoragonist with aKiof 0.58 nMat rat cloned 5-HT7 receptors. |
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V3164 | Lu AE58054 (Idalopirdine) | 467459-31-0 | Lu AE58054 (also known as Idalopirdine) is potent and selective antagonist of the 5-HT(6) receptor with Ki value of 0.83 nM. |
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V2927 | Lu AE58054 hydrochloride | 467458-02-2 | Lu AE58054 hydrochloride (also known as Idalopirdine hydrochloride) is potent and selective antagonist of the 5-HT(6) receptor with Ki value of 0.83 nM. |
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V24511 | Lumateperone toluenesulfonic acid (PTSA salt) | 1187020-80-9 | Lumateperone PTSA salt (ITI-722, ITI-007; Caplyta), thetoluenesulfonic acid salt of Lumateperone,is a dual 5HT2A receptor antagonist and dopamine receptor phosphoprotein modulator (DPPM), approved as an atypical antipsychotic in 2019 for the treatment of schizophrenia. |
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V4251 | Lumateperone tosylate | 1187020-80-9 | Lumateperone (ITI-007) tosylate is a 5-HT2A receptor blocker (antagonist) (Ki = 0.54 nM), a partial agonist at presynaptic D2 receptors, and an antagonist at postsynaptic D2 receptors (Ki = 32 nM) , dopamine D1 receptor modulator. |
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V23782 | Lurasidone | 367514-87-2 | Lurasidone (SM13496; SM-13496; Latuda) is an atypical antipsychotic drug approved for the treatment ofschizophrenia and bipolar disorders. |
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V33553 | LY 344864 | 186544-26-3 | LY-344864 (LY344864) is a novel, potent and selective receptor agonist of 5-HT1F with Ki of 6 nM. |
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V4839 | LY-344864 HCl | 1217756-94-9 | LY-344864 HCl, the hydrochloride salt of LY344864, is a novel, potent and selective receptor agonist of 5-HT1F with Ki of 6 nM. |
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V71152 | LY266097 hydrochloride | 172895-39-5 | LY266097 HCl is a selective 5-HT2B receptor antagonist (inhibitor) with pKi of 7.7, 9.8 and 7.6 for 5-HT2A, 5-HT2B and 5-HT2C respectively. |
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V0981 | LY310762 | 192927-92-7 | LY310762 (LY-310762; LY 310762) is a potent 5-HT1D serotonin receptor antagonist with important biological activity. |
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V32168 | LY334370 | 182563-08-2 | LY334370 is a selective 5-HT1F receptor agonist (activator) with Ki of 1.6 nM. |
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V71180 | m-CPBG hydrochloride (1-(3-Chlorophenyl)biguanide hydrochloride) | 2113-05-5 | m-CPBG (1-(3-Chlorophenyl)biguanide) HCl is a selective 5-HT3 agonist. |
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V71214 | Melitracen-d6 hydrochloride (melitacen d6 hydrochloride) | 1189648-08-5 | Melitracen-d6 ( HCl) is the deuterated form of Melitracen HCl. |
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V51293 | Metergoline | 17692-51-2 | Metergoline is a serotonin (5-HT) receptor and dopamine receptor antagonist (inhibitor) with pKis of 8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C respectively. |
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V25371 | Methotrimeprazine | 60-99-1 | Methotrimeprazine(Levomepromazine) is a potent phenothiazine-based neuroleptic drug. |
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V71154 | Methylergometrine (Methylergonovine; Ryegonovin free base; Spametrin F free base) | 113-42-8 | Methylergometrine (Methylergonovine) is an orally bioactive 5-HT2B ligand agonist. |
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V25462 | Metoclopramide hydrochloride hydrate | 54143-57-6 | Metoclopramide HCl hydrate is a potent and selective dopamine D2 receptor antagonist. |
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V71191 | Metoclopramide-d3 | 1216522-89-2 | Metoclopramide-d3 is the deuterated form of Metoclopramide. |
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