location： Home > Products > Signaling Pathways > GPCR & G Protein > 5-HT Receptor

Ondansetron (GR 38032; SN 307; GR-C507/75)

Price：

Market Price：

This product is for research use only, not for human use. We do not sell to patients.

Number： - + Pieces（InventoryPieces）

InvivoChem Cat #: V0975

CAS #: 99614-02-5 Purity ≥98%

Description: Ondansetron (GRC-50775; GR-38032; SN-307; GR38032; SN307; GR-C507/75; Zofran), an approved antiemetic drug, is a potent serotonin 5-HT3 receptor antagonist which is used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy. The 5-HT3A receptor antagonist ondansetron (0.3 nM) reversibly inhibited the 5-HT (30 microM) signal by 70% and at 3 nM it abolished the response. Acute ondansetron administration at the lowest dose (0.1 mg/kg, IP) tested had no effect, while other doses (0.33 and 1 mg/kg, IP) produced improvements in auditory gating.

References: Br J Pharmacol. 2000 Dec; 131(8): 1716–1722.

Related CAS #: 99614-01-4 (HCl); 103639-04-9 (HCl dihydrate)

Customer Validation

Top Publications Citing Invivochem Products

详情页公告 Product Catalog 2022

Bulletin Board

详情页公告 Guide to Product Handling

Publications Citing InvivoChem Products

Physicochemical and Storage Information
Protocol
Quality Control Documentation
Related Biological Data
Customer Review

Molecular Weight (MW)	293.36
Formula	C18H19N3O
CAS No.	99614-02-5
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO:<1 mg/mL
	Water: <1 mg/mL
	Ethanol: <1 mg/mL
SMILES Code	O=C1C(CN2C=CN=C2C)CCC(N3C)=C1C4=C3C=CC=C4.[H]Cl.[H]O[H].[H]O[H]
Synonyms	GR 38032; SN 307; GR 38032F; GRC50775; GR-38032; SN-307; GR38032; SN307; GR-C507/75; trade name: Zofran Chemical name: (RS)9methyl3(2methyl1Himidazol1yl)methyl23dihydro1Hcarbazol4(9H)one.

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
- Mass
- Concentration
- Volume
- Molecular Weight *
- =
- ×
- ×
The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂
- Concentration _(start)
- ×
- Volume _(start)
- =
- Concentration _(final)
- ×
- Volume _(final)
- ×
- =
- ×
- C1
- V1
- C2
- V2

These protocols are for reference only. InvivoChem does not independently validate these methods.

Purity ≥ 98%
COA
MSDS

Antagonism of the contractile response to 5-HT in the mouse ileum by granisetron, tropisetron, ondansetron and MDL 72222. Br J Pharmacol. 2000 Dec; 131(8): 1716–1722.	The ability of the 5-HT3 receptor selective antagonist, ondansetron, to inhibit the 5-HT-induced inward current in GI vagal afferent neurons is dependent upon extracellular glucose concentration. PLoS One. 2011 Jan 28;6(1):e16519.	5-HT3A CNiFER: Ondansetron antagonism. Neurogastroenterol Motil. 2012 Oct;24(10):e476

Home Prev Next Last page / pices

发评论

Your information is safe with us. * Required Fields.

Product name

Cat

Applicant name

Email address

Phone number

Organization name

Country

Requested quantity

Remarks