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    Ondansetron (GR 38032; SN 307; GR-C507/75)
    Ondansetron (GR 38032; SN 307; GR-C507/75)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0975
    CAS #: 99614-02-5 Purity ≥98%

    Description: Ondansetron (GRC-50775; GR-38032; SN-307; GR38032; SN307; GR-C507/75; Zofran), an approved antiemetic drug, is a potent serotonin 5-HT3 receptor antagonist which is used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy. The 5-HT3A receptor antagonist ondansetron (0.3 nM) reversibly inhibited the 5-HT (30 microM) signal by 70% and at 3 nM it abolished the response. Acute ondansetron administration at the lowest dose (0.1 mg/kg, IP) tested had no effect, while other doses (0.33 and 1 mg/kg, IP) produced improvements in auditory gating.

    References: Br J Pharmacol. 2000 Dec; 131(8): 1716–1722.

    Related CAS #: 99614-01-4 (HCl); 103639-04-9 (HCl dihydrate)

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    Molecular Weight (MW)293.36
    FormulaC18H19N3O
    CAS No.99614-02-5
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO:<1 mg/mL
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    SMILES Code O=C1C(CN2C=CN=C2C)CCC(N3C)=C1C4=C3C=CC=C4.[H]Cl.[H]O[H].[H]O[H]
    Synonyms

    GR 38032; SN 307; GR 38032F; GRC50775; GR-38032; SN-307; GR38032; SN307; GR-C507/75; trade name: Zofran

    Chemical name: (RS)9methyl3(2methyl1Himidazol1yl)methyl23dihydro1Hcarbazol4(9H)one.


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    Ondansetron
    Antagonism of the contractile response to 5-HT in the mouse ileum by granisetron, tropisetron, ondansetron and MDL 72222. Br J Pharmacol. 2000 Dec; 131(8): 1716–1722.
     
    Ondansetron
    The ability of the 5-HT3 receptor selective antagonist, ondansetron, to inhibit the 5-HT-induced inward current in GI vagal afferent neurons is dependent upon extracellular glucose concentration. PLoS One. 2011 Jan 28;6(1):e16519.
     
    Ondansetron
    5-HT3A CNiFER: Ondansetron antagonism. Neurogastroenterol Motil. 2012 Oct;24(10):e476


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