• Other

    Other
  • CN

    CN
  • EU

    EU
  • USA

    USA
    • My cart
    In the shopping cart is not goods, to choose and buy!
    • Product Name
    • Size
    • Quantity
    • Amount
      Selected items : 0 pieces Total : CHECK OUT()
      Mirtazapine (Org3770; 6-Azamianserin)
      Mirtazapine (Org3770; 6-Azamianserin)

      Price：
      Market Price：

      This product is for research use only, not for human use. We do not sell to patients.
      Number： - + Pieces（InventoryPieces）
      InvivoChem Cat #: V1018
      CAS #: 85650-52-8Purity ≥98%

      Description: Mirtazapine (formerly Org3770, Org 3770; trade names Remeron, Avanza, Axit, Mirtazon, Zispin), an approved atypical antidepressant drug, is an adrenergic and serotonin receptor antagonist used for treating depression. 

      References: Eur J Neurosci. 2000 Mar;12(3):1079-95; J Antimicrob Chemother. 2004 Jun;53(6):1086-9. 

      Customer Validation
      Official Supplier of
      • VE
      • OF
      • YALE
      • hhmi
      • 香港大学
      Related Products
      Publications Citing InvivoChem Products
      • Physicochemical and Storage Information
      • Protocol
      • Quality Control Documentation
      • Related Biological Data
      • Customer Review
      Molecular Weight (MW)265.35 
      FormulaC17H19N3 
      CAS No.85650-52-8  
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
      Solubility (In vitro)DMSO: 53 mg/mL (199.7 mM)  
      Water: <1 mg/mL
      Ethanol: 53 mg/mL (199.7 mM)  
      Other info

      Chemical Name: 2-methyl-1,2,3,4,10,14b-hexahydrobenzo[c]pyrazino[1,2-a]pyrido[3,2-f]azepine

      InChi Key: RONZAEMNMFQXRA-UHFFFAOYSA-N

      InChi Code: InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3

      SMILES Code: CN1CCN2C(C3=CC=CC=C3CC4=C2N=CC=C4)C1

      SynonymsORG-3770, Mirtazapine, Org3770, Org 3770, Remeron, Avanza, Axit, Mirtazon, Zispin  


      • Molarity Calculator
      • Dilution Calculator
      • The molarity calculator equation

        Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

        • Mass
        • Concentration
        • Volume
        • Molecular Weight *
        • =
        • ×
        • ×
      • The dilution calculator equation

        Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

        This equation is commonly abbreviated as: C1V1 = C2V2

        • Concentration (start)
        • ×
        • Volume (start)
        • =
        • Concentration (final)
        • ×
        • Volume (final)
        • ×
        • =
        • ×
        • C1
        •  
        • V1
        •  
        • C2
        •  
        • V2
      In Vitro

      In vitro activity: Mirtazapine displays marked affinity for cloned, human alpha2A-adrenergic (AR) receptors at which it blocks noradrenaline (NA)-induced stimulation of guanosine-5'-O-(3-[35S]thio)-triphosphate ([35S]-GTPgammaS) binding. Mirtazapine shows high affinity for cloned, human serotonin (5-HT)2C receptors at which it abolishes 5-HT-induced phosphoinositide generation. Mirtazapine markedly elevates dialysate levels of NA and, in FCX, DA, whereas 5-HT is not affected. Mirtazapine enhances the effectiveness of the electrical stimulation of the ascending 5-HT pathway by blocking both alpha-2 adrenergic auto- and heteroreceptors. Mirtazapine blocks the suppressant effect of microiontophoretically applied norepinephrine (NE) on the firing activity of CA3 dorsal hippocampus pyramidal neurons, indicating their antagonistic effects on postsynaptic alpha-2 adrenoceptors.

      In VivoMirtazapine (10-250 mg/kg i.v.) enhances dose-dependently the firing activity of the 5-HT neurons in naive rats, but not in 6-hydroxydopamine-pretreated rats. Mirtazapine (5 mg/kg/day, s.c., using osmotic minipumps) increases the spontaneous firing activity of locus coeruleus noradrenaline (NA) neurons in male Sprague-Dawley rats. Mirtazapine antagonizes both the enhancing effect of a low dose (10 mg/kg, i.v.) and the reducing effect of a high dose (100 mg/kg, i.v.) of the alpha 2-adrenoceptor agonist clonidine on the effectiveness of the electrical stimulation of the ascending 5-HT pathway in suppressing the firing activity of dorsal hippocampus CA3 pyramidal neurons. Mirtazapine (5 mg/kg s.c.) only slightly affects DOPAC and homovanillic acid levels in the striatum, hardly affects 5-HT release in freely moving rats, but clearly increased 5-hydroxyindole acetic acid. 
      Animal modelRats
      Formulation & Dosage10-250 mg/kg i.v.
      References

      Eur J Neurosci. 2000 Mar;12(3):1079-95; J Antimicrob Chemother. 2004 Jun;53(6):1086-9.  

      These protocols are for reference only. InvivoChem does not independently validate these methods.

      Mirtazapine
      The effect of mirtazapine on Lin-7C, CASK, and CTNNB1 mRNA expression levels. Sci Rep. 2014; 4: 5433.
      Mirtazapine
      qRT-PCR analysis of Lin-7C gene expression in hSCC cell lines. Sci Rep. 2014; 4: 5433.


      Mirtazapine
      Quantitative analysis of spontaneous metastasis using different human tumor cells. Sci Rep. 2014; 4: 5433.
      		 
      Mirtazapine
      Comparison of cellular proliferation in the control group (without mirtazapine) and the mirtazapine-treated groups. Sci Rep. 2014; 4: 5433.


      Mirtazapine
      The functional effect of mirtazapine for antimetastatic potential in human metastatic cancer cells. Sci Rep. 2014; 4: 5433.

      评论

        Home Prev Next Last page / pices

        发评论

        ×
        Your information is safe with us. * Required Fields.
        Products are for research use only;  We do not sell to patients
        Contact Us
        Contact Us
        Tel: 1-708-310-1919
        Fax: 1-708-557-7486
        Email: [email protected]
        Frequently Asked Questions
        Subscribe to our E-newsletter
        • Name*
        • *
        • E-mail*
        • *
        • instructions：
        • *
        Copyright 2020 InvivoChem LLC | All Rights Reserved
          Site map
        prompt
        Do you confirm the receipt?