5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71208 | FPPQ | 1648745-46-3 | FPPQ is a dual-acting (bifunctional) 5-HT3 (Ki = 0.9 nM) and 5-HT6 (Ki = 3 nM) receptor antagonist (inhibitor) with antipsychotic and pro-cognitive properties. |
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V4126 | Frovatriptan Succinate | 158930-09-7 | Frovatriptan Succinate (KB-295988; LS-173538; FT-0668872; D04264; Miguard; SB 209509), the succinate salt of frovatriptan, is a synthetic triptan that acts as an agonist of the serotonin (5-HT) receptor. |
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V80211 | Frovatriptan-d3 hydrochloride ((R)-Frovatriptan-d3 hydrochloride; SB 209509-d3 hydrochloride; VML 251-d3 hydrochloride) | Frovatriptan-d3 ( HCl) is the deuterated form of Frovatriptan. | |
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V29956 | Geissoschizine methyl ether | 60314-89-8 | Geissoschizine methyl ether, a naturally occuring indole alkaloid extrated from Uncaria hook, is a major active component of Yokukansan with psychotropic effects. |
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V21749 | GR 127935 HCl | 148642-42-6 | GR127935 HCl (GR-127935; GR 127935) is a novel, highly potent and selective 5-HT1B/1D receptor antagonist with pKis of 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors. |
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V0976 | Granisetron HCl (BRL 43694A) | 107007-99-8 | Granisetron HCl (BRL-43694; BRL43694; BRL-43694A; trade name: Kytril), an approved antiemetic drug, is a potent serotonin 5-HT3 receptor antagonist with antiemetic activity. |
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V2903 | GSK163090 | 844903-58-8 | GSK163090 is novel, potent, selective, and orally bioavailable antagonist of the 5-HT1A/B/D receptor that has the potential to be used as a fast-onset antidepressant/anxiolytic. |
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V1037 | Iloperidone (HP-873) | 133454-47-4 | Iloperidone (Fanapt, HP-873; HP 873; Zomaril), an atypical antipsychotic agent, is a potent antagonist of dopamine (D2)/serotonin (5-HT2) receptor which has been approved for the treatment of schizophrenia symptoms. |
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V71213 | Iloperidone-d3 (Iloperidone d3) | 1071167-49-1 | Iloperidone-d3 is the deuterated form of Iloperidone. |
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V1020 | Intepirdine (SB-742457; GSK-742457; RVT-101) | 607742-69-8 | Intepirdine (formerly GSK-742457; RVT-101; SB742457; SB 742457; GSK742457; SB-742457; RVT 101) is a potent and highly selective 5-HT6 receptor antagonist with potential cognition, memory, and learning-enhancing effects. |
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V3647 | Intepirdine HCl (SB-742457; GSK-742457; RVT-101) | Intepirdine HCl (GSK-742457; SB742457; RVT-101), the hydrochloride salt ofIntepirdine, is a novel, potent and highly selective 5-HT6 receptor antagonist with pKi of 9.63; it exhibits >100-fold selectivity over other receptors. | |
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V71183 | Iprindole | 5560-72-5 | Iprindole has antidepressant bioactivity and is a weak inhibitor of norepinephrine and 5-HT uptake. |
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V71134 | Isamoltane hemifumarate | 874882-92-5 | Isamoltane hemifumarate is a selective 5-HT1B receptor antagonist, inhibiting the binding of [125I]ICYP to the 5-HT1B recognition site in rat meninges with IC50 of 39 nM. |
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V71172 | JNJ-18038683 | 851376-05-1 | JNJ-18038683 is an antagonist of 5-hydroxytryptamine receptor 7 (5-HT7). |
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V80462 | JPC0323 | JPC0323 is a dual 5-HT2C/5-HT2A receptor PAM (positive allosteric modulator). | |
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V0964 | Ketanserin (R41468) | 74050-98-9 | Ketanserin (R41468; Vulketan; KJK-945; R-41468), an aprroved antihypertensive drug, is a potent and specific 5-HT2A serotonin receptor antagonist with a Ki of 2.5 nM for rat and human 5-HT2A. |
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V11985 | Ketanserin tartrate | 83846-83-7 | Ketanserin tartrate (R-41468; Vulketan) is an aprroved antihypertensive drug, acting as a potent and specific 5-HT2A serotonin receptor antagonist with a Ki of 2.5 nM for rat and human 5-HT2A. |
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V0998 | Lamotrigine (BW430C; LTG) | 84057-84-1 | Lamotrigine (Lamictal, BW 430C; BW430C; Crisomet, Lamictin, Lamitor), an approved anti-convulsant drug used in the treatment of epilepsy and bipolar disorder, is an inhibitor of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes. |
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V3980 | LASMIDITAN (COL 144, LY 573144) | 439239-90-4 | Lasmiditan (formerly known as COL-144 and LY-573144) is a novel and selective 5-HT(1F) receptor agonist with Ki of 2.1 nM versus Ki of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively. |
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V0966 | Latrepirdine (Dimebolin) HCl | 97657-92-6 | Latrepirdine HCl (Dimebon; Dimebolin; Dimeboline; Preparation 84), the hydrochloride salt ofLatrepirdine, is an orally bioactive, neuroactive andnon-selective antihistamine drug with the potential to be used for Alzheimers disease and Huntingtons disease. |
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