5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71118 | Donitriptan hydrochloride (F-11356) | 170911-68-9 | Donitriptan HCl (F-11356) is a potent, high-affinity 5-HT1B/1D receptor agonist (activator) with pKi of 9.4 and 9.3, respectively. |
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V18170 | Duloxetine ((S)-Duloxetine; LY248686) | 116539-59-4 | Duloxetine ((S)-Duloxetine; LY248686; LY-248686) is a serotonin-norepinephrine reuptake inhibitor(SNRI, Ki = 4.6 nM) used for treatment of major depressive disorder and generalized anxiety disorder (GAD),fibromyalgia and neuropathic pain. |
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V1016 | Duloxetine HCl (LY-248686 HCl) | 136434-34-9 | Duloxetine HCl (formerly LY-248686 HCl; LY248686; trade names Cymbalta; Yentreve), the hydrochloride salt of Duloxetine which is an approved antidepressant medication, is a potent serotonin-norepinephrine reuptake inhibitor (SNRI) with potential anti-depressive activity. |
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V71160 | DV-7028 hydrochloride | 133364-62-2 | DV-7028 is a selective serotonin 2 (5-HT2) receptor blocker (antagonist). |
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V0995 | Eletriptan HBr | 177834-92-3 | Eletriptan (formerly UK 116044; UK-116,044; UK-116,044-04; trade name Relpax), a triptan class of medication used for treatment of migraine headaches, is a potent and selective 5-HT1B and 5-HT1D receptor agonist with Ki of 0.92 nM and 3.14 nM, respectively. |
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V71220 | Eletriptan-d3 (UK-116044-d3) | 1287040-94-1 | Eletriptan-d3 is the deuterium labelled form of Eletriptan HBr. |
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V71192 | Eletriptan-d5 | 1126745-65-0 | Eletriptan-d5 is the deuterated form of Eletriptan. |
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V79286 | Eletriptan-d5 hydrochloride | Eletriptan-d5 ( HCl) is the deuterated form of Eletriptan HCl. | |
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V71206 | Eltoprazine dihydrochloride (DU 28853 dihydrochloride) | 143485-51-2 | Eltoprazine (DU 28853) diHCl is a 5-HT1A/5-HT1B receptor agonist (activator) and 5-HT2C receptor blocker (antagonist). |
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V4999 | Eltoprazine HCl | 98206-09-8 | Eltoprazine HCl (formerly DU-28853; DU28853 hydrochloride) is a novel and potent serenic or antiaggressive agent which also acts as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor. |
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V71133 | EMD 56551 | 133109-86-1 | EMD 56551 is a potent and specific 5-HT1A receptor agonist (activator). |
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V20658 | Eptapirone(F11440) | 179756-58-2 | Eptapirone (formerly known as F11440; L0068) is a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. |
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V1030 | Escitalopram Oxalate (Citalopram oxalate) | 219861-08-2 | Escitalopram Oxalate (Cipralex; Lexapro; Lu10171; Lu-10171; Citalopram; Cytalopram), the oxalate salt of Escitalopram which is an approved antidepressant drug, is a potent and selective serotonin (5-HT) reuptake inhibitor (SSRI) with a Ki of 0.89 nM. |
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V20852 | Eucalyptol | 470-82-6 | Eucalyptol (1,8-epoxy-p-Menthane; Cineole; 1,8-Cineole; NSC-617) is an organic compound and a colorless liquid, acting an inhibitor of 5-HT3 receptor ,potassium channel, TNF-α and IL-1β. |
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V51043 | Eucalyptol-d6 | 1263091-00-4 | Eucalyptol-d6 is the deuterium labelled form of Eucalyptol. |
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V3527 | F13714 fumarate | 208109-39-1 | F13714 fumarate is a selective 5-HT1A receptor biased agonist with antidepressant-like properties after a single dose in a mouse model of chronic mild stress. |
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V20913 | Fananserin | 127625-29-0 | Fananserin (RP-62203; RP62203) is a novel and potent antipsychotic agent acting as a5-hydroxytryptamine2 (5-HT2) receptor antagonist (Ki = 0.37 nM for the rat 5-HT2A receptor). |
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V1971 | Flopropione | 2295-58-1 | Flopropione is a spasmolytic or antispasmodic agent, acting as a 5-HT1A receptor antagonist and also a catechol-o-methyltransferase (COMT) inhibitor. |
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V0965 | Fluoxetine HCl (LY-110140) | 56296-78-7 | Fluoxetine HCl (LY-110140; Lilly-110140; Prozac, Sarafem, Animex-On, Pulvules, Eufor, Portal), the HCl salt of fluoxetine, is a potent and selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane with anti-depressant activity. |
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V1017 | Fluvoxamine maleate (DU23000 maleate) | 61718-82-9 | Fluvoxamine Maleate (formerly DU 23000; MK264; MK 264; DU-23000; Faverin, Fevarin, Floxyfral, Luvox), the maleate salt of Fluvoxamine which is an approved antidepressant drug, is a potent and selective serotonin (5-HT) reuptake inhibitor (SSRI) used in the treatment of a variety of diseases including obsessive-compulsive disorder, major depressive disorder (MDD), and anxiety disorders such as panic disorder and post-traumatic stress disorder (PTSD). |
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