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    Fluvoxamine maleate (DU23000 maleate)
    Fluvoxamine maleate (DU23000 maleate)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1017
    CAS #: 61718-82-9Purity ≥98%

    Description: Fluvoxamine Maleate (formerly DU 23000; MK264; MK 264; DU-23000; Faverin, Fevarin, Floxyfral, Luvox), the maleate salt of Fluvoxamine which is an approved antidepressant drug, is a potent and selective serotonin (5-HT) reuptake inhibitor (SSRI) used in the treatment of a variety of diseases including obsessive-compulsive disorder, major depressive disorder (MDD), and anxiety disorders such as panic disorder and post-traumatic stress disorder (PTSD).

    References: Psychopharmacology (Berl). 2004 Nov;176(2):195-203; Neuropharmacology. 2006 Sep;51(4):866-72.

    Related CAS#: 54739-18-3 (free base)

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    Molecular Weight (MW)434.41 
    FormulaC14H18F3N2O2.C4H4O4 
    CAS No.61718-82-9  (maleate); 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 87 mg/mL (200.3 mM) 
    Water: <1 mg/mL
    Ethanol: 87 mg/mL (200.3 mM) 
    Solubility (In vivo)Chemical Name: 2-[(E)-[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine maleate
    InChi Key: LFMYNZPAVPMEGP-PIDGMYBPSA-N
    InChi Code: InChI=1S/C15H21F3N2O2.C4H4O4/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,19H2,1H3;1-2H,(H,5,6)(H,7,8)/b20-14+;2-1-
    SMILES Code: FC(C1=CC=C(/C(CCCCOC)=N/OCCN)C=C1)(F)F.O=C(O)/C=C\C(O)=O
    SynonymsDU-23000 maleate; Fluvoxamine maleate, DU 23000; MK264; MK 264; DU23000; Faverin, Fevarin, Floxyfral, Luvox; MK-264;


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    In Vitro

    In vitro activity: Fluvoxamine increases [5-HT]ex levels in rat the prefrontal cortex and thalamus, and also increases [DA]ex levels in the striatum. Fluvoxamine maleate ameliorates tactile allodynia via spinal 5-HT2A/2C receptors, by acting on the receptors or 5-HT neurons.

    In VivoFluvoxamine maleate also exhibits the antinociception in a dose-dependent manner in the paw pressure test in non-ligated mice. Fluvoxamine maleate also induces antinociceptive effect in the acute paw pressure test, and this effect is antagonized by the 5-HT3 receptor antagonist granisetron. Fluvoxamine (10 and 30 mg/kg, i.p.) enhances synaptic efficacy in the hippocampo-mPFC pathway in a dose-dependent manner in the rat hippocampo-medial prefrontal cortex (mPFC). Fluvoxamine (10 and 30 mg/kg, i.p.) suppresses long-term potentiation (LTP) in the hippocampal CA1 field of anesthetized rats. Fluvoxamine (30 mg/kg, i.p.)-induced suppression of LTP is completely reversed by the 5-HT(1A) receptor antagonist NAN-190 (0.5 mg/kg, i.p), but not by the 5-HT(4) receptor antagonist GR 113808 (20 mg/rat, i.c.v.) and the 5-HT(7) receptor antagonist DR 4004 (10 mg/rat, i.c.v.). Fluvoxamine maleate reinforces the response to norepinephrine of isolated rat vas deferens incubated in Krebs-Henseleit solution. Fluvoxamine maleate and Fluoxetine hydrochloride inhibit the contraction induced by potassium ion on the isolated rat uterus preparation with IC50 of 3.99μM and 18.2μM, respectively. 
    Animal modelNon-ligated mice
    Formulation & Dosage10 and 30 mg/kg, i.p.
    ReferencesPsychopharmacology (Berl). 2004 Nov;176(2):195-203; Neuropharmacology. 2006 Sep;51(4):866-72. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     
    Fluvoxamine maleate
    Pyrene-actin-based screening identified fluvoxamine as a potent inhibitor of actin polymerization. Sci Rep. 2016; 6: 23372.  
     
    Fluvoxamine maleate
    Fluvoxamine inhibited invasion of hGICs in vivo and prolonged the survival of GBM mice. Sci Rep. 2016; 6: 23372.
     
    Fluvoxamine maleate
    Mechanism of glioma invasion inhibition by fluvoxamine with the suppression of FAK and Akt/mTOR signaling. Sci Rep. 2016; 6: 23372.


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