Fluvoxamine maleate (DU23000 maleate)

Alias: DU-23000 maleate; Fluvoxamine maleate; DU 23000; MK264; MK 264; DU23000; Faverin; Fevarin; Floxyfral; Luvox; MK-264
Cat No.:V1017 Purity: ≥98%
Fluvoxamine Maleate (formerly DU 23000; MK264; MK 264; DU-23000; Faverin, Fevarin, Floxyfral, Luvox), the maleate salt of Fluvoxamine which is an approved antidepressant drug, is a potent and selective serotonin (5-HT) reuptake inhibitor (SSRI) used in the treatment of a variety of diseases including obsessive-compulsive disorder, major depressive disorder (MDD), and anxiety disorders such as panic disorder and post-traumatic stress disorder (PTSD).
Fluvoxamine maleate (DU23000 maleate) Chemical Structure CAS No.: 61718-82-9
Product category: 5-HT Receptor
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
10mg
25mg
50mg
100mg
250mg
500mg
1g
Other Sizes

Other Forms of Fluvoxamine maleate (DU23000 maleate):

  • Fluvoxamine
  • (E)-Fluvoxamine-d4 maleate (fluvoxamine maleate d4 (maleate))
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Fluvoxamine Maleate (formerly DU 23000; MK264; MK 264; DU-23000; Faverin, Fevarin, Floxyfral, Luvox), the maleate salt of Fluvoxamine which is an approved antidepressant drug, is a potent and selective serotonin (5-HT) reuptake inhibitor (SSRI) used in the treatment of a variety of diseases including obsessive-compulsive disorder, major depressive disorder (MDD), and anxiety disorders such as panic disorder and post-traumatic stress disorder (PTSD).

Biological Activity I Assay Protocols (From Reference)
Targets
SSRIs
ln Vitro

In vitro activity: Fluvoxamine elevates [DA]ex levels in the striatum and raises [5-HT]ex levels in the rat prefrontal cortex and thalamus.[1] Through its action on 5-HT neurons or spinal 5-HT2A/2C receptors, fluvoxamine maleate reduces tactile allodynia.[2]

ln Vivo
Fluvoxamine maleate likewise demonstrates dose-dependent antinociception in the paw pressure test in non-ligated mice. In the acute paw pressure test, fluoxetine maleate also produces an antinociceptive effect that is countered by granisetron, an antagonist of the 5-HT3 receptor.[2] Fluvoxamine (10 and 30 mg/kg, i.p.) dose-dependently increases synaptic efficacy in the hippocampo-mPFC pathway in the rat hippocampo-medial prefrontal cortex (mPFC).[3] In rats under anesthesia, fluvoxamine (10 and 30 mg/kg, i.p.) inhibits long-term potentiation (LTP) in the hippocampal CA1 field. While the 5-HT(4) receptor antagonist GR 113808 (20 mg/rat, i.c.v.) and the 5-HT(7) receptor antagonist DR 4004 (10 mg/rat, i.c.v.) do not completely reverse the suppression of LTP induced by fluvoxamine (30 mg/kg, i.p.), they do.[4] An isolated rat vas deferens cultured in Krebs-Henseleit solution responds to norepinephrine more strongly when fluvoxamine maleate is added. With an IC50 of 18.2μM and 3.99μM, respectively, fluoxetine hydrochloride and fluoxetine maleate inhibit the contraction brought on by potassium ions in the isolated rat uterus preparation.[5]
Animal Protocol
10 and 30 mg/kg, i.p.
Non-ligated mice
References

[1]. Psychopharmacology (Berl) . 2004 Nov;176(2):195-203.

[2]. Neuropharmacology . 2006 Sep;51(4):866-72.

[3]. Brain Res . 2002 Sep 13;949(1-2):131-8.

These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C19H25F3N2O6
Molecular Weight
434.41
Exact Mass
434.17
Elemental Analysis
C, 52.53; H, 5.80; F, 13.12; N, 6.45; O, 22.10
CAS #
61718-82-9
Related CAS #
Fluvoxamine; 54739-18-3; (E)-Fluvoxamine-d4 maleate; 1432075-74-5; Fluvoxamine-d4 maleate
Appearance
Solid powder
SMILES
COCCCC/C(=N\OCCN)/C1=CC=C(C=C1)C(F)(F)F.C(=C\C(=O)O)\C(=O)O
InChi Key
LFMYNZPAVPMEGP-PIDGMYBPSA-N
InChi Code
InChI=1S/C15H21F3N2O2.C4H4O4/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,19H2,1H3;1-2H,(H,5,6)(H,7,8)/b20-14+;2-1-
Chemical Name
(Z)-but-2-enedioic acid;2-[(E)-[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine
Synonyms
DU-23000 maleate; Fluvoxamine maleate; DU 23000; MK264; MK 264; DU23000; Faverin; Fevarin; Floxyfral; Luvox; MK-264
HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: 86~87 mg/mL (198~200.3 mM)
Water: <1 mg/mL
Ethanol: ~87 mg/mL ( ~200.3 mM)
Solubility (In Vivo)
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.75 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL.
Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.

Solubility in Formulation 2: ≥ 2.5 mg/mL (5.75 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.

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Solubility in Formulation 3: ≥ 2.5 mg/mL (5.75 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.


Solubility in Formulation 4: 20 mg/mL (46.04 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication.

Solubility in Formulation 5: 20 mg/mL (46.04 mM) in phosphate buffer Saline (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication.
Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.

 (Please use freshly prepared in vivo formulations for optimal results.)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.3020 mL 11.5099 mL 23.0197 mL
5 mM 0.4604 mL 2.3020 mL 4.6039 mL
10 mM 0.2302 mL 1.1510 mL 2.3020 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

Calculator

Molarity Calculator allows you to calculate the mass, volume, and/or concentration required for a solution, as detailed below:

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An example of molarity calculation using the molarity calculator is shown below:
What is the mass of compound required to make a 10 mM stock solution in 5 ml of DMSO given that the molecular weight of the compound is 350.26 g/mol?
  • Enter 350.26 in the Molecular Weight (MW) box
  • Enter 10 in the Concentration box and choose the correct unit (mM)
  • Enter 5 in the Volume box and choose the correct unit (mL)
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  • The answer of 17.513 mg appears in the Mass box. In a similar way, you may calculate the volume and concentration.

Dilution Calculator allows you to calculate how to dilute a stock solution of known concentrations. For example, you may Enter C1, C2 & V2 to calculate V1, as detailed below:

What volume of a given 10 mM stock solution is required to make 25 ml of a 25 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=25 μM, V2=25 ml and V1 is the unknown:
  • Enter 10 into the Concentration (Start) box and choose the correct unit (mM)
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  • The answer of 62.5 μL (0.1 ml) appears in the Volume (Start) box
g/mol

Molecular Weight Calculator allows you to calculate the molar mass and elemental composition of a compound, as detailed below:

Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
Instructions to calculate molar mass (molecular weight) of a chemical compound:
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
  • Molecular mass (or molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
  • Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
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Reconstitution Calculator allows you to calculate the volume of solvent required to reconstitute your vial.

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  • The answer appears in the Volume (to add to vial) box
In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)
Step 2: Enter in vivo formulation (This is only a calculator, not the exact formulation for a specific product. Please contact us first if there is no in vivo formulation in the solubility section.)
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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
             (2) Be sure to add the solvent(s) in order.

Clinical Trial Information
NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04885530 Active
Recruiting
Drug: Ivermectin
Drug: Fluvoxamine
Drug: Fluticasone
Covid19 Susanna Naggie, MD June 8, 2021 Phase 3
NCT04510194 Active
Recruiting
Drug: Metformin
Drug: Placebo
Drug: Fluvoxamine
Covid19
SARS-CoV Infection
University of Minnesota January 1, 2021 Phase 3
NCT04160377 Recruiting Drug: Fluvoxamine Depressive Disorder
Endogenous Depression
Melancholia
Lingjiang Li August 1, 2019 Phase 2
NCT04963257 Recruiting Drug: sertraline fluvoxamine
Drug: sertraline
OCD Second Affiliated Hospital,
School of Medicine, Zhejiang
University
January 1, 2020 Phase 4
NCT05874037 Recruiting Drug: Fluvoxamine Long COVID Washington University School
of Medicine
May 15, 2023 Phase 2
Phase 3
Biological Data
  • Fluvoxamine maleate
    Pyrene-actin-based screening identified fluvoxamine as a potent inhibitor of actin polymerization.Sci Rep. 2016; 6: 23372.
  • Fluvoxamine maleate
    Fluvoxamine inhibited invasion of hGICs in vivo and prolonged the survival of GBM mice.Sci Rep. 2016; 6: 23372.
  • Fluvoxamine maleate
    Mechanism of glioma invasion inhibition by fluvoxamine with the suppression of FAK and Akt/mTOR signaling.Sci Rep. 2016; 6: 23372.
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