| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
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| Targets |
5-HT1A Receptor
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|---|---|
| ln Vitro |
F13714 is directed towards 5-HT1A autoreceptors [1].
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| ln Vivo |
F13714 (4–16 mg/kg) can robustly normalize depressive-like behavior in the forced swim test (FST) in UCMS mice after just one administration. F13714 does not affect p-CREB levels, but it does rescue deficits in p-ERK1/2 levels in the cortex and hippocampus[1].
F13714 reduces immobility in mice by 30.3% and 19.5%, respectively at the doses 2 and 4 mg/kg[1]. F13714 (0.5-2 mg/kg) administered alone during a 2-hour measurement significantly and dose-dependently lowers rectal body temperature in mice[1]. F13714 (2.5 mg/kg) exhibits properties similar to those of anxiolytics and antidepressants in naïve rats[1]. |
| References |
| Molecular Formula |
C25H29CLF2N4O5
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|---|---|
| Molecular Weight |
538.9768
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| Exact Mass |
538.18
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| Elemental Analysis |
C, 55.71; H, 5.42; Cl, 6.58; F, 7.05; N, 10.40; O, 14.84
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| CAS # |
208109-39-1
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| Related CAS # |
F 13714; 208109-38-0
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| PubChem CID |
9958888
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| Appearance |
Solid powder
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
10
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| Rotatable Bond Count |
8
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| Heavy Atom Count |
37
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| Complexity |
666
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CC1=C(N=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F)NC.C(=C/C(=O)O)\C(=O)O
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| InChi Key |
HZJWIYFEDQNBEU-WLHGVMLRSA-N
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| InChi Code |
InChI=1S/C21H25ClF2N4O.C4H4O4/c1-14-3-5-16(27-19(14)25-2)12-26-13-21(24)7-9-28(10-8-21)20(29)15-4-6-18(23)17(22)11-15;5-3(6)1-2-4(7)8/h3-6,11,26H,7-10,12-13H2,1-2H3,(H,25,27);1-2H,(H,5,6)(H,7,8)/b;2-1+
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| Chemical Name |
(E)-but-2-enedioic acid;(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[[5-methyl-6-(methylamino)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]methanone
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| Synonyms |
F-13714; F13714; F-14679; F 14679; F14679; F13714 fumarate; F 13714
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~250 mg/mL (~463.9 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (4.64 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (4.64 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8554 mL | 9.2768 mL | 18.5536 mL | |
| 5 mM | 0.3711 mL | 1.8554 mL | 3.7107 mL | |
| 10 mM | 0.1855 mL | 0.9277 mL | 1.8554 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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