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    Escitalopram Oxalate (Citalopram oxalate)
    Escitalopram Oxalate (Citalopram oxalate)

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1030
    CAS #: 219861-08-2Purity ≥98%

    Description: Escitalopram Oxalate (Cipralex; Lexapro; Lu10171; Lu-10171; Citalopram;Cytalopram), the oxalate salt of Escitalopram which is an approved antidepressant drug, is a potent and selective serotonin (5-HT) reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram Oxalate is the S-(+)-enantiomer of citalopram and can inhibit [3H]-5-HT uptake and [125I]-RTI-55 binding in COS-1 cells expressing the human serotonin transporter (5-HTT) with Ki values of 6.6±1.4nM and 3.9±2.2nM, respectively.

    References: Encephale. 2007 Dec;33(6):965-72; J Med Chem. 2010 Aug 26;53(16):6112-21.

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    Molecular Weight (MW)414.43 
    CAS No.219861-08-2 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 83 mg/mL (200.3 mM) 
    Water: 25 mg/mL (60.3 mM) 
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile;oxalic acid


    InChi Code: InChI=1S/C20H21FN2O.C2H2O4/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;3-1(4)2(5)6/h4-9,12H,3,10-11,14H2,1-2H3;(H,3,4)(H,5,6)/t20-;/m0./s1

    SMILES Code: CN(C)CCC[[email protected]@]1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.C(=O)(C(=O)O)O

    SynonymsLu-10-171; Escitalopram Oxalate; Cipralex; Lexapro; (S)-Citalopram Oxalate;  Lu10171; Lu 10171; UNII-5U85DBW7LO; Citalopram;Cytalopram; Escitalopram Lexapro 

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    In Vitro

    In vitro activity: Escitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of escitalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. In vitro studies show that escitalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Escitalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of escitalopram is found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Escitalopram does not inhibit monoamine oxidase.

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    Encephale. 2007 Dec;33(6):965-72; J Med Chem. 2010 Aug 26;53(16):6112-21. 

    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Escitalopram Oxalate
    J Med Chem. 2010 Aug 26;53(16):6112-21.
    Escitalopram Oxalate
    J Med Chem. 2010 Aug 26;53(16):6112-21.


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