5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V11877 | Cisapride | 81098-60-4 | Cisapride (formerly R51619; R 51619; R-51619; Kaudalit; Prepulsid; Kinestase; Pridesia; Presid; Propulsid) is a benzamide-based nonselective agonist of serotonin 5-HT4 receptor. |
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V7602 | Citalopram Hydrobromide (Lu 10-171) | 59729-32-7 | Citalopram Hydrobromide(Lu-10-171) is a potent and FDA approved antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) class. |
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V0990 | Clomipramine HCl (G34586) | 17321-77-6 | Clomipramine HCl (G-34586; G34586; Trade names: Anafranil, Clomicalm), the hydrochloride salt of clomipramine which is a tricyclic antidepressant (TCA), is a potent blocker of serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) with Ki of 0.14, 54 and 3 nM, respectively. |
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V0962 | Clozapine (HF 1854) | 5786-21-0 | Clozapine(LX 100129; HF1854, LX100129; Leponex; Fazaclo; CLOZARIL; Clozapin; Clozaril) is an atypical antipsychotic drug wand a 5-HT antagonist used in the treatment of schizophrenia. |
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V71142 | CP-135807 | 151272-90-1 | CP-135807 is an orally bioactive and selective 5-HT1D agonist (IC50=3.1 nM). |
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V4608 | CP-809101 HCl | 1215721-40-6 | CP-809101 HCl (CP809101), the hydrochloride salt ofCP-809101, is a novel, potent and selective 5-HT2C receptor agonist with antipsychotic effects. |
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V18922 | Cyamemazine | 3546-03-0 | Cyamemazine (Tercian; Cianatil; cyamepromazine) is a typical antipsychotic drug of the phenothiazine class. |
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V71222 | Cyamemazine-d6 | 1216608-24-0 | Cyamemazine-d6 is the deuterium labelled form of Cyamemazine. |
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V1918 | Cyclobenzaprine HCl (MK-130) | 6202-23-9 | Cyclobenzaprine HCl (also known as MK130; Flexeril), the hydrochloride salt of Cyclobenzaprine, is a potent muscle relaxant by blocking pain sensations, used as a medication for the treatment of skeletal muscle spasms and associated pain in acute musculoskeletal conditions. |
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V71209 | Cyclobenzaprine-d3 hydrochloride (MK130-d3 (hydrochloride)) | 1184983-42-3 | Cyclobenzaprine-d3 ( HCl) is the deuterium labelled form of Cyclobenzaprine HCl. |
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V19012 | Cyproheptadine HCl hydrate | 41354-29-4 | Cyproheptadine HCl hydrate is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist. |
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V0977 | Dapoxetine HCl (LY-210448 HCl) | 129938-20-1 | Dapoxetine HCl (formerly known as LY210448; LY-210448; trade name Priligy), an antidepressant, is a novel, potent, short-acting and selective serotonin reuptake inhibitor (SSRI) that has alto been used for the treatment of premature ejaculation. |
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V71162 | Dehydro Palonosetron (RS 42358-197) | 135729-56-5 | Dehydro Palonosetron (RS 42358-197) is a specific, orally bioactive 5-HT3 receptor antagonist. |
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V71141 | Dehydroaripiprazole hydrochloride (OPC-14857 hydrochloride; DM-14857 hydrochloride) | 1008531-60-9 | Dehydroaripiprazole (OPC-14857) HCl is the bioactive metabolite of Aripiprazole. |
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V1034 | Desvenlafaxine (WY 45233; O-Desmethylvenlafaxine) | 93413-62-8 | Desvenlafaxine (WY-45233; WY45233; brand names Pristiq, Desfax), the active metabolite of the antidepressant venlafaxine, is a potent inhibitor/antagonist of the reuptake of serotonin (5-HT) transporter and norepinephrine (NE) transporter with Ki of 40.2 nM and 558.4 nM respectively. |
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V1033 | Desvenlafaxine Succinate (WY 45233; O-Desmethylvenlafaxine) | 448904-47-0 | Desvenlafaxine Succinate (formerly WY45233; WY 45233; O-desmethylvenlafaxine; trade name Pristiq, Desfax), the succinate salt of Desvenlafaxine which is an approved antidepressant drug, is a novel and potent serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively. |
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V71127 | Didesmethyl cariprazine | 839712-25-3 | Didesmethyl cariprazine is a metabolite of cariprazine and serves as the major circulating active moiety. |
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V18113 | Dihydroergotamine Mesylate (DHE; Migranal) | 6190-39-2 | Dihydroergotamine Mesylate (DHE; Migranal) is a naturally occuring ergot alkaloid widely used to treat migraines. |
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V71144 | DOI hydrochloride | 42203-78-1 | DOI HCl is a serotonin 5-HT2A/2C receptor agonist/activator with Kis of 0.7 nM, 2.4 nM and 20 nM for h5-HT2A, h5-HT2C and h5-HT2B receptors respectively. |
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V15974 | Dolasetron (MDL-73147) | 115956-12-2 | Dolasetron (MDL-73147) is a potent serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. |
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