| Size | Price | Stock | Qty |
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| 500mg |
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| 1g |
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| 2g |
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| 10g |
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| Other Sizes |
Purity: ≥98%
| Targets |
COMT; 5-HT1A Receptor
Serotonin receptor antagonist (5-HT receptor antagonist) [1] The antispasmodic agent flopropione is commonly used as part of conservative therapy for ureteral stones in Japan, typically administered to reduce ureteral spasms that cause stone stagnation and pain symptoms. It is often prescribed together with an extract of Quercus salicina Blume/Quercus stenophylla Makino (QS) and non-steroidal anti-inflammatory drugs (NSAIDs) for renal colic associated with urolithiasis. [3] |
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| ln Vitro |
Flopropione does not exhibit Lorentzian relaxation below its T(g) temperature. When the temperature drops below its T(g), flopropione exhibits greater molecular mobility than nifedipine. The entire temperature range of flopropione exhibits an Arrhenius temperature dependence, and the extrapolation of tau (beta) measured above T (g) by dielectric relaxation agreed with tau (beta) measured below T (g) by TAM/MDSC.
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| ln Vivo |
Retrospective comparisons with patients whose passage was spontaneous have been made to assess the impact of flopropione, an antispasmodic medication, on the rate of calculus passage from the urinary tract. After administration, flopropine has been demonstrated to outperform the control in cumulative passage rate with statistical significance. It has been demonstrated that flopropine has a spasmolytic effect on the smooth muscle of the pancreatobiliary and urinary systems in addition to the gastrointestinal tract[3].
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| Enzyme Assay |
Flopropione has been shown to exert a spasmolytic effect not only on smooth muscle of the gastrointestinal tract but also on smooth muscle of the pancreas and urinary systems, as described in the discussion section of the literature. [3]
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| Animal Protocol |
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| References | |||
| Additional Infomation |
Flopropione is an organic molecular entity.
Flopropione was identified in a high-throughput chemical screen performed in high glucose (8.3 mM) using INS-1E cells expressing a proinsulin-luciferase reporter. It ranked 20th among compounds that increased luciferase secretion, with a reported mechanism as a serotonin receptor antagonist. No further experimental data (e.g., IC50, EC50, potency) or validation in human islets was provided for this compound in the study [1]. |
| Molecular Formula |
C9H10O4
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|---|---|---|
| Molecular Weight |
182.17
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| Exact Mass |
182.058
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| Elemental Analysis |
C, 59.34; H, 5.53; O, 35.13
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| CAS # |
2295-58-1
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| Related CAS # |
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| PubChem CID |
3362
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| Appearance |
Yellow to orange solid powder
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| Density |
1.372g/cm3
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| Boiling Point |
341.7ºC at 760mmHg
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| Melting Point |
177°C
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| Flash Point |
174.7ºC
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| Vapour Pressure |
4E-05mmHg at 25°C
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| Index of Refraction |
1.618
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| LogP |
1.396
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
13
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| Complexity |
180
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O([H])C1C([H])=C(C([H])=C(C=1C(C([H])([H])C([H])([H])[H])=O)O[H])O[H]
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| InChi Key |
PTHLEKANMPKYDB-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C9H10O4/c1-2-6(11)9-7(12)3-5(10)4-8(9)13/h3-4,10,12-13H,2H2,1H3
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| Chemical Name |
1-(2,4,6-trihydroxyphenyl)propan-1-one
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| Synonyms |
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (13.72 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (13.72 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (13.72 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.4894 mL | 27.4469 mL | 54.8938 mL | |
| 5 mM | 1.0979 mL | 5.4894 mL | 10.9788 mL | |
| 10 mM | 0.5489 mL | 2.7447 mL | 5.4894 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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