Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA.DNA's double-helical structure is entwined, which leads to the winding issue. Isomerization enzymes called topoisomerases work on DNA's topology. One strand of a DNA double helix is cut by type I topoisomerase, which is followed by relaxation and reannealing of the cut strand. Type I topoisomerases are divided into two subclasses: type IB topoisomerases, which employ a controlled rotary mechanism, and type IA topoisomerases, which share many structural and mechanistic features with the type II topoisomerases. One DNA double helix's two strands are cut by Type II topoisomerase, which then reanneals the cut strands after passing through another DNA double helix that hasn't been broken. Type IIA and type IIB topoisomerases, two subclasses of this class with related structures and mechanisms, are further divided.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1389 | Doxorubicin HCl (adriamycin; NSC 123127) | 25316-40-9 | Doxorubicin HCl (formerly known as Adriamycin; FI 106; Adriblastina; DOXOCELL; Doxolem; NSC-123127 etc.) is an anthracycline antibiotic agent with anticancer activity. |
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V32536 | Dxd | 1599440-33-1 | Dxd,an exatecan analog, is a novel and potent DNA topoisomerase I inhibitor(IC50=0.31 μM) with anticancer activity, and is used as a conjugated drug of HER2-targeting ADC (DS-8201a). |
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V1403 | Ellagic acid | 476-66-4 | Ellagic acid (Elagostasine, Gallogen; Alizarine Yellow; Benzoaric acid; CCRIS-774; HSDB-7574; Lagistase), the dilactone of hexahydroxydiphenic acid, is a naturally occuring phenol and an antioxidant found in numerous fruits and vegetables. |
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V1405 | Enoxacin (AT-2266) | 74011-58-8 | Enoxacin (formerly AT-2266; CI-919; NSC-629661;Penetrex; Comprecin; Enoxacino)is an orally bioavailable and broad-spectrum fluoroquinolone antibiotic used to treat various infections, such as UTIs-urinary tract infections and gonorrhea. |
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V1395 | Epirubicin HCl | 56390-09-1 | Epirubicin HCl (formerly 4'-epidoxorubicin; epiADR; epidoxorubicin; IMI 28; IMI-28; Ellence; Pharmorubicin PFS), the hydrochloride salt of the 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin, is a new anthracycline analog and a semisynthetic L-arabino derivative of doxorubicin approved as an anticancer medication. |
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V1390 | Etoposide (VP-16) | 33419-42-0 | Etoposide (formerly VP-16, VP-16213; Toposar; VePesid; Lastet; EPEG), a chemotherapeutic drug used for the treatments of various cancers, is a semisynthetic derivative of the naturally occuring podophyllotoxin which inhibits DNA synthesis via topoisomerase II inhibitory activity. |
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V20873 | Exatecan mesylate (DX8951) | 169869-90-3 | Exatecanmesylate (DX-8951) is the methylate of Exatecan, which is a semisynthetic analog of camptothecin with improved water solubility. |
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V1413 | Flumequine (R-802) | 42835-25-6 | Flumequine(formerly R-802;R 802;R802) is a synthetic quinolone, 1st generation and broad-spectrum chemotherapeutic antibiotic that was once used to treat bacterial infections but has beenremoved from market. |
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V1399 | Gatifloxacin (AM-1155) | 112811-59-3 | Gatifloxacin (formerly also known as AM-1155, CG5501, BMS-206584; PD135432; Tequin; Zymar; Gatiflo; Zymaxid; AM 1155)is a fourth-generation antibiotic of the fluoroquinolone family used to treat tuberculosis and pneumonia, it inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. |
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V1420 | GSK-J1 | 1373422-53-7 | GSKJ1 (GSK-J1; GSK-J 1; GSK-J-1) is a novel, highly selective and potent inhibitor of histone demethylase (H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A) with potential antineoplastic activity. |
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V1394 | Idarubicin HCl | 57852-57-0 | Idarubicin HCl (NSC-256439; IMI 30; NSC 256439; 4-DMDR; IDA; 4-Demethoxydaunomycin; Idamycin), the hydrochloride salt form of Idarubicin, is a potent anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor approved for use as an anticancer drug. |
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V1393 | Irinotecan (CPT-11) | 97682-44-5 | Irinotecan (also known as CPT-11; Camptosar; Irinophore C; CPT11; Irinotecan lactone; Irinotecanum), a semisynthetic analog of camptothecin and the prodrug of 7-ethyl-10-hydroxy-camptothecin (SN-38), is a topoisomerase I inhibitor approved for use as an anticancer drug. |
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V1410 | Irinotecan HCl Trihydrate | 136572-09-3 | Irinotecan HCl trihydrate (formerly CPT-11;CPT 11;Irinophore C; Irinotecan lactone; Irinotecanum), the hydrochloride salt and trihydrated form of irinotecan which is an antitumor drug and a soluble prodrug of SN-38, is a semisynthetic derivative of camptothecin approved for cancer treatment. |
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V34178 | Irinotecan hydrochloride | 100286-90-6 | Irinotecan hydrochloride (also known as CPT-11; (+)-Irinotecan) is a potent topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively. |
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V1411 | Levofloxacin [(-)-Ofloxacin] | 100986-85-4 | Levofloxacin [(-)-Ofloxacin, Levaquin, Tavanic, Fluoroquinolone,Iquix, Quixin], a synthetic fluoroquinolone and the levo isomer of ofloxacin, is a broad-spectrum antibacterial drug approved for treating UTIs, RTIs etc. |
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V1422 | Marbofloxacin | 115550-35-1 | Marbofloxacin (Forcyl, Kelacyl,Zeniquin, Aristos, Boflox, Marbocyl, Aurizon), a carboxylic acid derivative, is a 3rd generation and broad spectrum antibiotic of the fluoroquinolone class used as a veterinary medication. |
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V1412 | Mitoxantrone (mitozantrone) | 65271-80-9 | Mitoxantrone (formerly known as NSC-301739; CL232325; Mitozantrone; Novantrone; Mitroxone; Neotalem; Onkotrone; Pralifan),the hydrochloride salt ofMitoxantrone which is an approved anticancer medication, is a potent type II topoisomerase inhibitorwith potential antitumor activity. |
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V1404 | Mitoxantrone HCl (mitozantrone) | 70476-82-3 | Mitoxantrone HCl (formerly NSC-301739; NSC301739; DHAQ; CL-232325; Mitroxone; Neotalem; Onkotrone; Pralifan; Novantrone),the hydrochloride salt of Mitoxantrone which is an anthracenedione anticancer agent, is a potent type II topoisomerase inhibitor with potential antitumor activity. |
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V1416 | Moxifloxacin HCl (BAY12-8039) | 186826-86-8 | Moxifloxacin HCl (formerly BAY12-8039; BAY12-8039; BAY 12-8039; Avelox; Avalox; Avelon; Vigamox; Moxeza), the hydrochloride salt of moxifloxacin, is an orally bioactive, broad spectrum and 4th generation antibacterial drug of the fluoroquinolone class with high activity against both Gram positive and Gram negative bacteria. |
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V1407 | Nalidixic acid (NSC-82174) | 389-08-2 | Nalidixic acid (formerly known as NSC-82174; NSC82174; Nevigramon, Neggram, Wintomylon, WIN 18,320), a synthetic 1,8-naphthyridine antimicrobial agent used to treat infections, is the first synthetic quinolone-based antibiotic with a narrow spectrum of bacteriocidal effects. |
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