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    Moxifloxacin HCl (BAY12-8039)
    Moxifloxacin HCl (BAY12-8039)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1416
    CAS #: 186826-86-8Purity ≥98%

    Description: Moxifloxacin HCl (also known as BAY12-8039 HCl) is an oral and synthetic and fourth generation fluoroquinolone class of antibacterial agent with a broad antibacterial spectrum against Gram positive bacteria and Gram negative bacteria in vitro. The antibacterial activity of moxifloxacin is from the inhibition effect of DNA topoisomerase II and topoisomerase IV which are involved in bacterial DNA replication, transcription, recombination and repair. The oral bioavailability of moxifloxacin is absolutely good which can be up to 90%. There are no many potenti[al drug interactions because that moxifloxacin is not a inhibitor or substrate of the hepatic cytochrome P-450 isoenzyme system.

    References: Tuberculosis (Edinb). 2008 Mar;88(2):127-31; J Pharm Biomed Anal. 2005 Jun 1;38(1):8-13.

    Related CAS#: 151096-09-2 (Moxifloxacin)

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    Molecular Weight (MW)437.89 
    FormulaC21H24FN3O4.HCl 
    CAS No.186826-86-8  (Moxifloxacin HCl); 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 88 mg/mL (201 mM)
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Solubility (In vivo)30% PEG400+0.5% Tween80+5% Propylene glycol: 30 mg/mL
    SynonymsBAY12-8039 HCl; BAY12-8039; BAY 12-8039; BAY-12-8039; BAY128039; BAY-128039; BAY 128039; Moxifloxacin, Avelox, Avalox, Avelon, Vigamox, Moxeza


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    In Vitro

    In vitro activity: Moxifloxacin exerts its effects by trapping a DNA drug enzyme complex and specifically inhibiting ATP-dependent enzymes topoisomerase II (DNA gyrase) and topoisomerase IV. Moxifloxacin shows in-vitro potency against M. tuberculosis H37Rv with MIC of 0.177 μg/mL. Moxifloxacin has broad Grampositive and Gram-negative activity. Moxifloxacin shows in vitro and clinical efficacy against Staphylococcus aureus, Streptococcus pneumoniae, Str. pyogenes, Haemophilus influenzae, H. parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Chlamydia pneumoniae and Mycoplasma pneumoniae. Moxifloxacin has activity against mycobacteria in addition to M. tuberculosis; Moxifloxacin is more active against M. kansasii than M. aviumcomplex: specifically MIC90 for M. avium > M. intracellulare > M. kansasii at 4, 2 and 2 μg/mL, respectively. MIC90 for M. chelonae > M. fortuitum at 16 and 0.5 μg/mL, respectively.


    Cell Assay: Moxifloxacin (Hydrochloride) is a synthetic fluoroquinolone antibiotic agent. Antibacterial Moxifloxacin is an extended-spectrum fluoroquinolone which has improved coverage against gram-positive cocci and atypical pathogens compared with older fluoroquinolone agents, while retaining good activity against gram-negative bacteria. The antibacterial spectrum of moxifloxacin includes all major upper and lower respiratory tract pathogens; it is one of the most active fluoroquinolones against pneumococci, including penicillin- and macrolide-resistant strains. Moxifloxacin has limited phototoxic potential. In clinical trials, moxifloxacin had clinical success rates of 88-97% and bacteriologic eradication rates of 90-97%. Moxifloxacin is a safe and effective antimicrobial that will be useful for treating acute sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia. Moxifloxacin possibly stimulates lipid peroxidation and enhances phagocytosis, as depicted by MDA production and survival prolongation, without being toxic as depicted by white blood cell count. Clinical indications: Abdominal abscess; Acute bronchitis; Acute sinusitis; Bacterial infection Toxicity: Symptoms of overdose include CNS and gastrointestinal effects such as decreased activity, somnolence, tremor, convulsions, vomiting, and diarrhea. The minimal lethal intravenous dose in mice and rats is 100 mg/kg.

    In VivoMoxifloxacin combined with RIF/pyrazinamide (PZA) reduces treatment time by up to 2 months compared to regimens with isoniazid (INH)/RIF/PZA in a mouse model designed to mimic human disease. Similar results with a stable cure are reached after 4 months in mice treated twice weekly with RIF/Moxifloxacin/PZA compared to cure in 6 months when daily treated with RIF/INH/PZA. 100 mg/kg Moxifloxacin in mice gives activity comparable to INH; increased dose in mice to 400 mg/kg Moxifloxacin daily results in spleen CFU counts lower than for INH 25 mg/kg although the differences are not statistically significant. AUC/MIC ratio correlates best with in-vivo efficacy for the fluoroquinolones in a mouse model of tuberculosis. 
    Animal model Mouse model of tuberculosis
    Formulation & Dosage N/A
    ReferencesTuberculosis (Edinb). 2008 Mar;88(2):127-31; J Pharm Biomed Anal. 2005 Jun 1;38(1):8-13. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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