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    Levofloxacin [(-)-Ofloxacin]
    Levofloxacin [(-)-Ofloxacin]

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1411
    CAS #: 100986-85-4Purity ≥98%

    Description: Levofloxacin [(-)-Ofloxacin, Levaquin, Tavanic, Fluoroquinolone, Iquix, Quixin], a synthetic fluoroquinolone and the levo isomer of ofloxacin, is a broad-spectrum antibacterial drug approved for treating UTIs, RTIs etc. It inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. Levofloxacin is used to treat various bacterial infections including respiratory, gastrointestinal, urinary tract, and abdominal infections. Levofloxacin is active against most aerobic Gram-positive and Gram-negative organisms and demonstrates moderate activity against anaerobes.

    References: Drugs. 1994 Apr;47(4):677-700; Antimicrob Agents Chemother. 1992 Apr;36(4):860-6.

    Related CAS: 117707-40-1 (Desmethyl Levofloxacin, a metabolite of Levofloxacin)

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    Molecular Weight (MW)361.37 
    CAS No.100986-85-4 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 24 mg/mL (66.4 mM) 
    Water: 11 mg/mL (30.4 mM)
    Ethanol: 9 mg/mL (24.9 mM) 
    Other info

    Chemical Name: (S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid


    InChi Code: InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m0/s1

    SMILES Code: O=C(C(C1=O)=CN2[[email protected]@H](C)COC3=C(N4CCN(C)CC4)C(F)=CC1=C23)O

    Synonyms(-)-Ofloxacin; Fluoroquinolone; Levofloxacin, Levaquin, Tavanic, Iquix, Quixin

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    In Vitro

    In vitro activity: Levofloxacin is active against most aerobic Gram-positive and Gram-negative organisms and demonstrates moderate activity against anaerobes. Levofloxacin is two-fold more active than ciprofloxacin against Streptococcus pneumoniae and 2- to 4-fold more active than ciprofloxacin against Staphylococcus aureus, Xanthomonas maltophilia, and Bacteroides fragilis. Levofloxacin is two- to eightfold more active than ciprofloxacin against coagulase-negative staphylococci and Acinetobacter spp., although these improvements in potency may not be clinically relevant. Levofloxacin inhibits 90% of streptococci when it is used at concentrations of 1 mg/mL to 2 mg/mL. Levofloxacin exhibits twofold greater inhibitory and bactericidal activities than ofloxacin against either extracellular or intracellular tubercle bacilli. Levofloxacin has the least inhibitory effect on osteoblastic cell growth, with a 50% inhibitory concentration of approximately 80 mg/mL at 48 and 72 hours. Levofloxacin results in strong inhibition of calcium deposition, as determined on day 14 by alizarin red staining and biochemical analysis. Levofloxacin inhibits glycosaminoglycan synthesis initially and DNA synthesis and mitochondrial function secondarily at actual arthropathic concentrations in cultured rabbit chondrocytes but that these changes are reversible and not enough to kill the cells.

    In VivoLevofloxacin is as efficacious as or more efficacious than that with ciprofloxacin in systemic as well as pyelonephritis infections in mice. Levofloxacin achieves higher concentrations in the serum and tissue of mice than does ciprofloxacin. 
    Animal modelMice
    Formulation & DosageN/A

    Drugs. 1994 Apr;47(4):677-700; Antimicrob Agents Chemother. 1992 Apr;36(4):860-6. 

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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