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Mitoxantrone HCl (mitozantrone)

Alias: NSC-301739; CL-232325; NSC301739; CL 232325; NSC 301739; DHAQ; CL232325; Mitozantrone; Mitoxantrone HCl; Mitoxantrone dihydrchloride; US brand name: Novantrone. NSC 301739; DHAQ; CL232325; Foreign brand names: Mitroxone; Neotalem; Onkotrone; Pralifan
Cat No.:V1404 Purity: ≥98%
Mitoxantrone HCl (formerly NSC-301739; NSC301739; DHAQ; CL-232325; Mitroxone; Neotalem; Onkotrone; Pralifan; Novantrone),the hydrochloride salt of Mitoxantrone which is an anthracenedione anticancer agent, is a potent type II topoisomerase inhibitor with potential antitumor activity.
Mitoxantrone HCl (mitozantrone)
Mitoxantrone HCl (mitozantrone) Chemical Structure CAS No.: 70476-82-3
Product category: Topoisomerase
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
50mg
100mg
250mg
500mg
1g
Other Sizes

Other Forms of Mitoxantrone HCl (mitozantrone):

  • Mitoxantrone (mitozantrone)
  • Mitoxantrone diacetate
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Mitoxantrone HCl (formerly NSC-301739; NSC301739; DHAQ; CL-232325; Mitroxone; Neotalem; Onkotrone; Pralifan; Novantrone), the hydrochloride salt of Mitoxantrone which is an anthracenedione anticancer agent, is a potent type II topoisomerase inhibitor with potential antitumor activity. It has an IC50 of 2.0 μM in HepG2 and 0.42 mM in MCF-7/wt cells for TOPO II inhibition. It is a confirmed treatment for multiple sclerosis and an anti-neoplastic for leukemia and other cancers. By preventing DNA synthesis and the division of cells, mitoxantrone suppressed leukemia. It impacted several immune cells, including macrophages, T cells, and B cells, among others. Numerous DSBs (DNA strand breaks), chromatin structure alterations, and other events were caused by its interference with TOPO-II-mediated DNA cleavage.

Biological Activity I Assay Protocols (From Reference)
Targets
PKC ( IC50 = 8.5 μM ); Topoisomerase II
ln Vitro

In vitro activity: Mitoxantrone causes DNA fragmentation and the proteolytic cleavage of poly(ADP-ribose) polymerase (PARP), a marker of caspase activation, in every patient examined, proving that the induction of apoptosis is the cause of mitoxantrone's cytotoxic effect. Mitoxantrone stimulates IkappaBalpha degradation and activates NFkappaB in the promyelocytic leukemia cell line HL60, but not in the variant cells, HL60/MX2 cells, which express a truncated alpha isoform of topoisomerase II and lack the beta isoform, leading to a different subcellular distribution. In a dose-dependent manner, mitoxantrone prevents the growth of B cells, antigen-specific T-cell lines (TCLs), or activated peripheral blood monocytic leukemia cells (PBMCs) stimulated on antigen-presenting cells (APCs). Low doses of mitoxantrone cause PBMCs, monocytes, and DCs to undergo apoptosis; higher doses result in cell lysis.

ln Vivo
To determine whether mitoxantrone (MXN) was effective against CPXV in vivo, 0.25 or 0.5 mg/kg of drug was administered intraperitoneally to 4–6 week old female C57Bl/6 mice 1 day post-intraperitoneal inoculation. Log-rank tests were performed comparing survival times between the two MXN treatment groups relative the mock-treated group. A p-value of 0.025 was considered statistically significant, after a Bonferroni correction for the comparisons of the two MXN dose groups to the mock-treated. The lower dose of MXN significantly improved the survival time of infected animals, with the median day-of-death (MDD) in infected animals increasing from day 7 to day 9 (p = 0.0015). The 0.5 mg/kg dose of MXN improved the MDD to 12 days (p = 0.0005). Twenty-five percent of the animals treated with 0.5 mg/kg MXN survived compared to 5% of mock-treated animals (Fig. 2 ). Administration of higher levels of MXN or additional dosages were not beneficial (data not shown).[1]
Mitoxantrone administered at the ideal dose (1.6 mg/kg/day; as a free base) results in a statistically significant number of 60-day survivors (curative effect) in mice with IP implanted L1210 leukemia. Mitoxantrone and ADM given intravenously (IV) also demonstrate efficacious antitumor activities in Lewis lung carcinoma implanted in SC, producing a 60% and a 45% ILS, respectively.
Enzyme Assay
Mitoxantrone inhibits PKC in a non-competitive manner with respect to phosphatidylserine and ATP, but in a competitive manner with respect to histone H1, where its Ki value is 6.3 μM. Cell viability is reduced when B-CLL cells are treated with mitoxantrone (0.5 μg/mL) for 48 hours. Poly(ADP-ribose) polymerase (PARP) is subjected to proteolytic cleavage and DNA fragmentation upon induction by mitoxantrone, indicating that the cytotoxic effect of the drug is a result of apoptosis induction. Human breast carcinoma cell lines MDA-MB-231 and MCF-7 exhibit cytotoxicity to mitoxantrone, with IC50 values of 18 and 196 nM, respectively.
Cell Assay
In standard 96-well plates, the human breast carcinoma cell lines MDA-MB-231 and MCF-7 are seeded. The culture medium is swapped out for one containing varying concentrations of mitoxantrone (10-5 to 5 μM) with or without DHA (30 μM) for a period of seven days following seeding. The tetrazolium salt assay is used to determine the overall viability of cells.
Animal Protocol
In agreement with a previous report which found that mitoxantrone/MXN exhibited no in vivo activity against intranasal VACV infection in BALB/c mice (Deng et al., 2007), we observed no efficacy against intranasal CPXV infection in BALB/c mice. Mitoxantrone did, however, demonstrate efficacy when used to treat intraperitoneally-infected C57Bl/6 mice, suggesting that differences in the route of infection and in mouse strain susceptibility to infection may influence MXN’s efficacy. While related anthracenediones have been reported to have in vivo antiviral activity against viruses unrelated to poxviruses (Dang et al., 2009, Sill et al., 1974), to our knowledge this is the first report of limited in vivo antiviral activity by MXN against poxviruses.[1]
1.6 mg/kg/day; i.p. or i.v.
Mice
ADME/Pharmacokinetics
Absorption, Distribution and Excretion
Poorly absorbed following oral administration
1000 L/m2
21.3 L/hr/m2 [Elderly patients with breast cancer receiving IV administration of 15-90 mg/m2]
28.3 L/hr/m2 [Non-elderly patients with nasopharyngeal carcinoma receiving IV administration of 15-90 mg/m2]
16.2 L/hr/m2 [Non-elderly patients with malignant lymphoma receiving IV administration of 15-90 mg/m2]
Metabolism / Metabolites
Hepatic
Hepatic
Half Life: 75 hours
Biological Half-Life
75 hours
Toxicity/Toxicokinetics
Toxicity Summary
Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone also interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA. It has a cytocidal effect on both proliferating and nonproliferating cultured human cells, suggesting lack of cell cycle phase specificity.
Hepatotoxicity
Chemotherapy with mitoxantrone alone is associated with serum enzyme elevations in up to 40% of patients, but these elevations are generally mild-to-moderate in severity, transient and not accompanied by symptoms or jaundice. Higher rates of liver enzyme elevations have been reported with combination chemotherapeutic regimens that include mitoxantrone. In high doses, mitoxantrone has been associated with a high rate of jaundice, but the degree of hyperbilirubinemia has been mild, transient and not associated with significant serum enzyme elevations or evidence of hepatitis. Rare instances of acute liver injury have been reported in patients taking mitoxantrone, including a single case of drug-rash with eosinophilia and systemic symptoms (DRESS). The latency to onset was 8 weeks and the pattern of serum enzyme elevations was cholestatic and later mixed. Immunoallergic features were prominent and appeared to respond to corticosteroid therapy. Other drugs were being taken and the association with mitoxantrone was not definite (Case 1). Thus, idiosyncratic and clinically apparent liver injury from mitoxantrone may occur but is quite rare.
Likelihood score: D (possible rare cause of clinically apparent liver injury).
Effects During Pregnancy and Lactation
◉ Summary of Use during Lactation
Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy, such as mitoxantrone. It might be possible to breastfeed safely during intermittent therapy with an appropriate period of breastfeeding abstinence, but the duration of abstinence is not clear. In one patient, mitoxantrone was still detectable in milk 28 days after a dose of 6 mg per square meter. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk. Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.
◉ Effects in Breastfed Infants
One mother received 3 daily doses of 6 mg/sq. m. of mitoxantrone intravenously along with 5 daily doses of etoposide 80 mg/sq. m. and cytarabine 170 mg/sq. m. intravenously. She resumed breastfeeding her infant 3 weeks after the third dose of mitoxantrone at a time when mitoxantrone was still detectable in milk. The infant had no apparent abnormalities at 16 months of age.
◉ Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Protein Binding
78%
References

[1]. Antiviral Res. 2011 Dec 11;93(2):305–308. Inhibition of cowpox virus and monkeypox virus infection by mitoxantrone

[2]. Mechanism of action of mitoxantrone. Neurology.2004 Dec 28;63(12 Suppl 6):S15-8.

Additional Infomation
Pharmacodynamics
Mitoxantrone has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa, and IL-2.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C22H29CLN4O6.HCL
Molecular Weight
517.4
Exact Mass
516.154
Elemental Analysis
C, 51.07; H, 5.84; Cl, 13.70; N, 10.83; O, 18.55
CAS #
70476-82-3
Related CAS #
65271-80-9; 70476-82-3 (HCl salt); 70711-41-0 (diacetate)
PubChem CID
4212
Appearance
Black solid powder
Boiling Point
805.7ºC at 760 mmHg
Melting Point
203-205ºC
Flash Point
441.1ºC
LogP
2.392
Hydrogen Bond Donor Count
8
Hydrogen Bond Acceptor Count
10
Rotatable Bond Count
12
Heavy Atom Count
32
Complexity
571
Defined Atom Stereocenter Count
0
SMILES
Cl[H].Cl[H].O=C1C2=C(C([H])=C([H])C(=C2C(C2=C(C([H])=C([H])C(=C21)N([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])O[H])N([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])O[H])=O)O[H])O[H]
InChi Key
ZAHQPTJLOCWVPG-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H
Chemical Name
1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione;dihydrochloride
Synonyms
NSC-301739; CL-232325; NSC301739; CL 232325; NSC 301739; DHAQ; CL232325; Mitozantrone; Mitoxantrone HCl; Mitoxantrone dihydrchloride; US brand name: Novantrone. NSC 301739; DHAQ; CL232325; Foreign brand names: Mitroxone; Neotalem; Onkotrone; Pralifan
HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: ~89 mg/mL (~172.0 mM)
Water: ~89 mg/mL (172.0 mM)
Ethanol: <1 mg/mL
Solubility (In Vivo)
Solubility in Formulation 1: ≥ 2.5 mg/mL (4.83 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL.
Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.

Solubility in Formulation 2: ≥ 2.5 mg/mL (4.83 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.

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Solubility in Formulation 3: Saline: 30 mg/mL


Solubility in Formulation 4: 2 mg/mL (3.87 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication (<60°C).

 (Please use freshly prepared in vivo formulations for optimal results.)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 1.9327 mL 9.6637 mL 19.3274 mL
5 mM 0.3865 mL 1.9327 mL 3.8655 mL
10 mM 0.1933 mL 0.9664 mL 1.9327 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)
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Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
             (2) Be sure to add the solvent(s) in order.

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CTID: NCT00901927
Phase: Phase 2    Status: Terminated
Date: 2020-04-03
A Study of Olaratumab (IMC-3G3) in Prostate Cancer
CTID: NCT01204710
Phase: Phase 2    Status: Completed
Date: 2019-09-20
Fludarabine, Mitoxantrone and Rituximab in Relapsed or Primary Failing Advanced Follicular Non-Hodgkin's Lymphoma
CTID: NCT00169208
Phase: Phase 2    Status: Completed
Date: 2019-08-28
Four Drug Reinduction With Bortezomib for Relapsed or Refractory ALL or LL in Children and Young Adults
CTID: NCT02535806
Phase: Phase 2    Status: Terminated
Date: 2019-08-13
Clofarabine, Etoposide, and Mitoxantrone for Relapsed and Refractory Acute Leukemias
CTID: NCT00882076
Phase: Phase 1    Status: Terminated
Date: 2019-07-24
Medium Dose of Cytarabine and Mitoxantrone
CTID: NCT04024241
Phase:    Status: Unknown status
Date: 2019-07-18
Prexasertib in Combination With MEC in Relapsed/Refractory AML and High Risk MDS - a Phase I Trial
CTID: NCT03735446
Phase: Phase 1    Status: Terminated
Date: 2019-06-12
Study to Determine Safety, Pharmacokinetics and Efficacy of GMI-1271 in Combination With Chemotherapy in AML
CTID: NCT02306291
Phase: Phase 1/Phase 2    Status: Completed
Date: 2019-05-17
FCM-R (Fludarabine, Cyclophosphamide, Mitoxantrone, Rituximab) in Previously Untreated Patients With Chronic Lymphocytic Leukemia (CLL) < 70 Years
CTID: NCT00254410
Phase: Phase 2    Status: Completed
Date: 2019-05-01
Re-Induction Therapy for Relapsed Pediatric T-Cell Acute Lymphoblastic Leukemia or Lymphoma
CTID: NCT02518750
Phase: Phase 2    Status: Terminated
Date: 2019-04-03
Phase I Study of Weekly Intravenous PS-341 (Bortezomib) Plus Mitoxantrone
CTID: NCT00059631
Phase: Phase 1    Status: Completed
Date: 2018-11-15
Study of Cabozantinib (XL184) Versus Mitoxantrone Plus Prednisone in Men With Previously Treated Symptomatic Castration-resistant Prostate Cancer
CTID: NCT01522443
Phase: Phase 3    Status: Terminated
Date: 2018-05-23
Bortezomib and Vorinostat in Younger Patients With Refractory or Relapsed MLL Rearranged Hematologic Malignancies
CTID: NCT02419755
Phase: Phase 2    Status: Terminated
Date: 2018-03-07
Trial of Intensive Chemotherapy With or Without Volasertib in Patients With Newly Diagnosed High-Risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)
CTID: NCT02198482
Phase: Phase 2    Status: Terminated
Date: 2018-02-28
Phase I Study of Mitoxantrone and Etoposide Combined With Hydroxychloroquine, for Relapsed Acute Myelogenous Leukemia
CTID: NCT02631252
Phase: Phase 1    Status: Terminated
Date: 2018-02-23
-----------
A Phase 2, Randomized, Biomarker-driven, Clinical Study in Patients with Relapsed or Refractory Acute Myeloid Leukemia (AML) with an Exploratory Arm in Patients with Newly Diagnosed High-Risk AML and Exploratory
CTID: null
Phase: Phase 2    Status: Prematurely Ended
Date: 2017-10-10
A Phase 3, Multicenter, Randomized, Open-Label Study of Guadecitabine (SGI-110) versus Treatment Choice in Adults with Previously Treated Acute Myeloid Leukemia
CTID: null
Phase: Phase 3    Status: Completed
Date: 2017-06-19
A Phase 3, Multicenter, Randomized, Open-Label Study of Guadecitabine (SGI-110) versus Treatment Choice in Adults with Myelodysplastic Syndromes (MDS) or Chronic Myelomonocytic Leukemia (CMML) Previously Treated with Hypomethylating Agents
CTID: null
Phase: Phase 3    Status: Completed
Date: 2017-03-17
A Phase 3 Open-Label, Multicenter, Randomized Study of ASP2215 versus Salvage Chemotherapy in Patients with Relapsed or Refractory Acute Myeloid Leukemia (AML) with FLT3 Mutation
CTID: null
Phase: Phase 3    Status: Ongoing, GB - no longer in EU/EEA, Completed
Date: 2016-04-20
Study Protocol LAM 2013/01
CTID: null
Phase: Phase 3    Status: Ongoing
Date: 2015-02-04
A Phase 3 Open-Label Randomized Study of Quizartinib Monotherapy Versus Salvage Chemotherapy in Subjects with FLT3-ITD Positive Acute Myeloid Leukemia (AML) Refractory To or Relapsed After First-line Treatment With or Without Hematopoietic Stem Cell Transplant (HSCT) Consolidation.
CTID: null
Phase: Phase 3    Status: Ongoing, Completed
Date: 2014-06-18
A PHASE III MULTICENTER, RANDOMIZED STUDY COMPARING CONSOLIDATION WITH (90)YTTRIUM-LABELED IBRITUMOMAB TIUXETAN (ZEVALIN®) RADIOIMMUNOTHERAPY VS AUTOLOGOUS STEM CELL TRANSPLANTATION (ASCT) IN PATIENTS WITH RELAPSED FOLLICULAR LYMPHOMA (FL) AGED 18-65 YEARS
CTID: null
Phase: Phase 3    Status: Ongoing
Date: 2013-10-08
NOPHO-DBH AML 2012 Protocol
CTID: null
Phase: Phase 3    Status: Trial now transitioned, Ongoing
Date: 2013-01-22
Response-Adapted Sequential Azacitidine And Chemotherapy in Patients > 60 Years Old With Newly Diagnosed AML Eligible for Chemotherapy and allogeneic hematopoietic cell transplantation: A Multicentre Phase I/II study of the East German Hematology and Oncology Study Group (OSHO)
CTID: null
Phase: Phase 1, Phase 2    Status: Completed
Date: 2012-08-31
A Phase 3, randomized, double-blind, controlled trial of cabozantinib (XL184) vs. mitoxantrone plus prednisone in men with previously treated symptomatic castration-resistant prostate cancer
CTID: null
Phase: Phase 3    Status: Completed
Date: 2012-07-11
An Open-label, Randomized Phase 3 Study of Inotuzumab Ozogamicin Compared to a Defined Investigator’s Choice in Adult Patients with Relapsed or Refractory CD22-Positive Acute Lymphoblastic Leukemia (ALL)
CTID: null
Phase: Phase 3    Status: Completed
Date: 2012-06-13
A Randomized Phase 2 Study of Human Anti-PDGFRα Monoclonal Antibody IMC-3G3 plus Mitoxantrone plus Prednisone or Mitoxantrone plus Prednisone in Metastatic Castration-Refractory Prostate Cancer (CRPC) Following Disease Progression or Intolerance on Docetaxel-based Chemotherapy.
CTID: null
Phase: Phase 2    Status: Completed
Date: 2010-10-20
Dutch-Belgian pediatric AML protocol for children with newly diagnosed acute myeloid leukemia, based on the NOPHO-AML 2004 study
CTID: null
Phase: Phase 3    Status: Completed
Date: 2010-05-04
A phase Ib, open-label, multi-center dose-finding study of oral panobinostat (LBH589) in combination with ara-C and mitoxantrone as salvage therapy for refractory or relapsed acute myeloid leukemia
CTID: null
Phase: Phase 1, Phase 2    Status: Completed
Date: 2010-01-08
Phase II Trial of Combined Immunochemotherapy with
CTID: null
Phase: Phase 2    Status: Completed
Date: 2009-12-07
MITOXANTRONE/GLATIRAMER ACETATE COMBINED TREATMENT IN THE THERAPY OF SECONDARY-PROGRESSIVE MULTIPLE SCLEROSIS
CTID: null
Phase: Phase 3    Status: Prematurely Ended
Date: 2009-07-30
Brief induction chemoimmunotherapy with Rituximab + Bendamustine + Mitoxantrone followed by Rituximab in elderly patients with advanced stage previously untreated follicular lymphoma
CTID: null
Phase: Phase 2    Status: Completed
Date: 2009-07-20
TREATMENT STUDY FOR CHILDREN AND ADOLESCENTS WITH ACUTE PROMYELOCYTIC LEUKEMIA
CTID: null
Phase: Phase 3    Status: Ongoing
Date: 2009-07-16
Attenuated dose Rituximab with ChemoTherapy In CLL:
CTID: null
Phase: Phase 4    Status: GB - no longer in EU/EEA
Date: 2009-06-25
A Randomized Phase III study comparing conventional chemotherapy to low dose total body irradiation-based conditioning and hematopoietic cell transplantation from related and unrelated donors as consolidation therapy for older Patients with AML in first Complete Remission.
CTID: null
Phase: Phase 3    Status: Prematurely Ended, Completed
Date: 2009-03-26
A Randomized, Risk and Age Adapted Comparison of the Dose-Dense Regimen S-HAM (sequential high dose cytosine arabinoside and mitoxantrone) versus Standard Double Induction for Initial Chemotherapy of Adult Patients with Acute Myeloid Leukemia
CTID: null
Phase: Phase 3    Status: Completed
Date: 2009-03-10
An exploratory phase IIa study to evaluate the safety and immunological effects of intravenous interferonβ-1a (IFNβ-1a, Rebif®) therapy in the induction of tolerance to IFNβ in MS patients with neutralising antibodies (NAbs) to subcutaneous IFNβ-1a (Rebif® or Avonex®)
CTID: null
Phase: Phase 2    Status: Prematurely Ended
Date: 2009-02-16
ADMIRE: Does the ADdition of Mitoxantrone Improve REsponse
CTID: null
Phase: Phase 4    Status: GB - no longer in EU/EEA
Date: 2009-02-09
A Phase 1b/2 Study to Assess the Safety and Efficacy of AMG 102 in Combination with
CTID: null
Phase: Phase 1, Phase 2    Status: Prematurely Ended, Completed
Date: 2009-01-05
An Open-Label, Randomized, Phase 3 Study of Inotuzumab Ozogamicin (CMC-544) Administered in Combination With Rituximab Compared to a Defined Investigator’s Choice Therapy in Subjects With Relapsed or Refractory, CD22- Positive, Follicular B-Cell Non Hodgkin’s Lymphoma
CTID: null
Phase: Phase 3    Status: Prematurely Ended, Completed
Date: 2008-04-25
Klassische Konditionierung immunologischer Reaktionen bei Patienten mit Multipler Sklerose während Mitoxantrontherapie
CTID: null
Phase: Phase 4    Status: Completed
Date: 2007-12-12
A Phase II Study of PHA-739358 in Patients with Metastatic Hormone Refractory Prostate Cancer.
CTID: null
Phase: Phase 2    Status: Completed
Date: 2007-11-29
HIGH-DOSE SEQUENTIAL CHEMOTHERAPY AND RITUXIMAB (R-HDS) IN HIV+ PATIENTS WITH NON-HODGKIN LYMPHOMA (NHL) REFRACTORY OR RELAPSED AFTER 1st LINE TREATMENT
CTID: null
Phase: Phase 2    Status: Prematurely Ended
Date: 2007-10-19
A randomised phase III study to compare arsenic trioxide (ATO) combined to ATRA versus standard ATRA and anthracycline-based chemotherapy (AIDA regimen) for newly diagnosed, non high-risk acute promyelocytic leukemia
CTID: null
Phase: Phase 3    Status: Completed
Date: 2007-07-10
A Phase 2 Multicenter, Open-label Study of CNTO 328 (Anti-IL-6 Monoclonal Antibody) in Combination with Mitoxantrone versus Mitoxantrone in Subjects with Metastatic Hormone-Refractory Prostate Cancer (HRPC)
CTID: null
Phase: Phase 2    Status: Completed
Date: 2007-05-23
A Randomized, Open Label Multi-Center Study of XRP6258 At 25 mg/m2 in Combination With Prednisone Every 3 Weeks Compared To Mitoxantrone in Combination With Prednisone For The Treatment of Hormone Refractory Metastatic Prostate Cancer Previously Treated With A Taxotere®-Containing Regimen
CTID: null
Phase: Phase 3    Status: Completed
Date: 2006-11-29
Exploratory trial to evaluate the risk-benefit ratio of the use of mitoxantrone in patients under treatment with high dose interferon-beta-1a for relapsing-remitting or relapsing secondary progresive multiple sclerosis with high activity.
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2006-09-08
Curative and palliative treatment of adults aged > 60 years with AML.A randomised trial by OSHO on the role of (1) early intensification {OSHO protocol} vs. common standard arm of German AML Intergroup Study, (2) allografting as consolidative immunotherapy vs. a second consolidation course in elderly patients,(3) prospective evaluation of the decision between curative and palliative treatment-intention.
CTID: null
Phase: Phase 3    Status: Ongoing
Date: 2006-03-08
Phase III multicentric IIL study, three randomized arms (R-CVP vs R-CHOP vs R-FM),for treatment of patients with stage II-IV follicular lymphoma
CTID: null
Phase: Phase 3    Status: Completed
Date: 2006-01-30
A phase III, multicentric randomized study for the treatment of young patients with unfavorable prognosis Diffuse Large Cell B Lymphoma IPI 2-3 . Dose-dense chemotherapy Rituximab +/- intensive and high-dose chemo-immunotherapy with autologus pheripherical staminal cells.
CTID: null
Phase: Phase 3    Status: Completed
Date: 2006-01-20
Treatment protocol for relapsed anaplastic large cell lymphoma of childhood and adolescence
CTID: null
Phase: Phase 3    Status: Completed
Date: 2005-12-23
International Collaborative Treatment Protocol for the Infants Under One Year with Acute Lymphoblastic or Biphenotypic Leukemia
CTID: null
Phase: Phase 3    Status: Ongoing, Completed
Date: 2005-11-24
A pilot multi-centre randomised controlled trial of sequential treatment with Mitoxantrone and Glatiramer Acetate vs. Interferon Beta-1a in early active relapsing remitting Multiple Sclerosis.
CTID: null
Phase: Phase 4    Status: Completed
Date: 2005-07-26
MULTI-CENTRE, RANDOMISED, PHASE III TRIAL COMPARING HIGH DOSE SEQUENTIAL CHEMOTHERAPY hds WITH RITUXIMAB AND AUTOLOGOUS PERIPHERAL BLOOD PROGENITUR ALL TRANSPLANTION VERSUS 2- WEEKLY CHOP WITH RITUXIMAB AS FRONT LINE THERAPY OF HIGH RISK PATIENT WITH DIFFUSE LARGE B- CELL NON HODGKIN LYMPHOMA
CTID: null
Phase: Phase 3    Status: Completed
Date: 2005-04-12
A multicentre, phase III, open-label, randomised study in patients with advanced follicular lymphoma evaluating the benefit of maintenance therapy with Rituximab (MabThera®) after induction of response with chemotherapy plus Rituximab in comparison with no maintenance therapy
CTID: null
Phase: Phase 3    Status: Completed
Date: 2005-02-22
MULTICENTTRIC, NATIONAL, SINGLE BLIND,CONTROLLED IN PARALLEL GROUP TO EVALUATE THE SAFETY AND EFFICACY OF THE SEQUENTIAL COMBINATION OF MITOXANTRONE AND BETA INTERFERON REBIF 44 mcg X 3 TIMES WEEKLY IN PATIENTS AFFECTED BY MULTIPLE SCLEROSIS, IN THE FIRST STEP OF THE DISEASE
CTID: null
Phase: Phase 3    Status: Ongoing, Completed
Date: 2004-11-19
Evaluation of the intensification of post-remissional therapy in the treatment of high-risks adult Acute Lymphoblastic Leukemia and monitoring of the minimal residual disease
CTID: null
Phase: Phase 3    Status: Completed
Date: 2004-11-08
Pixantrone (BBR 2778) versus Other Chemotherapeutic Agents for Third-line Single Agent Treatment of Patients with Relapsed Aggressive Non-Hodgkin’s Lymphoma: A Randomized, Controlled, Phase III Comparative Trial
CTID: null
Phase: Phase 3    Status: Ongoing, Prematurely Ended, Completed
Date: 2004-11-02
IntReALL HR 2010
CTID: null
Phase: Phase 2    Status: Trial now transitioned, Ongoing, Prematurely Ended
Date:

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